Outcomes of retinal pigment epithelial detachment in Vogt-Koyanagi-Harada disease: a longitudinal analysis
Abstract Background The aim of this study was to report the clinical profile and outcomes of retinal pigment epithelial detachment (PED) in Vogt-Koyanagi-Harada (VKH) disease, and to evaluate the correlation between PED and the subsequent development of central serous chorioretinopathy (CSC) through...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-11-01
|
| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12886-022-02675-6 |
| _version_ | 1798016883167854592 |
|---|---|
| author | Chuanzhen Zheng Kaixuan Wang Mi Zhang Qingqin Tao Xiaorong Li Xiaomin Zhang |
| author_facet | Chuanzhen Zheng Kaixuan Wang Mi Zhang Qingqin Tao Xiaorong Li Xiaomin Zhang |
| author_sort | Chuanzhen Zheng |
| collection | DOAJ |
| description | Abstract Background The aim of this study was to report the clinical profile and outcomes of retinal pigment epithelial detachment (PED) in Vogt-Koyanagi-Harada (VKH) disease, and to evaluate the correlation between PED and the subsequent development of central serous chorioretinopathy (CSC) throughout the whole corticosteroid treatment course. Methods The retrospective study enrolled a total of 470 eyes with VKH, and 12 eyes with VKH and PED were recruited. Patients were divided into two groups according to the CSC onset or not throughout the whole course (the CSC group and non-CSC group). Best-corrected visual acuity (BCVA) improvement, and PED angle (PEDA, the angle between the two lines of the vertex of the lifted retinal pigment epithelium to the two edge points of the Bruch membrane) were compared between the two groups. Results CSC developed at the site of the PED in 5 of the 12 eyes with PED, while in the remaining 7 eyes PED gradually resolved following therapy. The prevalence of PED and CSC in VKH was 2.55% (12/470) and 1.06% (5/470), respectively. BCVA improvement in the non-CSC group was greater than that in the CSC group, but without a statistical difference (P = 0.25). PEDA was significantly smaller in the CSC group than in the non-CSC group (P = 0.03). Conclusion PEDA is an ideal parameter to reflect hydrostatic pressure and stretches for RPE. As PED predisposes to the development of CSC in selected VKH eyes, PEDA may be a valuable predictive factor for the development of classic CSC in VKH cases. |
| first_indexed | 2024-04-11T15:57:46Z |
| format | Article |
| id | doaj.art-3b9198bde0b24ba1ad0f50167adc2ba5 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-04-11T15:57:46Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-3b9198bde0b24ba1ad0f50167adc2ba52022-12-22T04:15:06ZengBMCBMC Ophthalmology1471-24152022-11-0122111110.1186/s12886-022-02675-6Outcomes of retinal pigment epithelial detachment in Vogt-Koyanagi-Harada disease: a longitudinal analysisChuanzhen Zheng0Kaixuan Wang1Mi Zhang2Qingqin Tao3Xiaorong Li4Xiaomin Zhang5Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye HospitalTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye HospitalTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye HospitalTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye HospitalTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye HospitalTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye HospitalAbstract Background The aim of this study was to report the clinical profile and outcomes of retinal pigment epithelial detachment (PED) in Vogt-Koyanagi-Harada (VKH) disease, and to evaluate the correlation between PED and the subsequent development of central serous chorioretinopathy (CSC) throughout the whole corticosteroid treatment course. Methods The retrospective study enrolled a total of 470 eyes with VKH, and 12 eyes with VKH and PED were recruited. Patients were divided into two groups according to the CSC onset or not throughout the whole course (the CSC group and non-CSC group). Best-corrected visual acuity (BCVA) improvement, and PED angle (PEDA, the angle between the two lines of the vertex of the lifted retinal pigment epithelium to the two edge points of the Bruch membrane) were compared between the two groups. Results CSC developed at the site of the PED in 5 of the 12 eyes with PED, while in the remaining 7 eyes PED gradually resolved following therapy. The prevalence of PED and CSC in VKH was 2.55% (12/470) and 1.06% (5/470), respectively. BCVA improvement in the non-CSC group was greater than that in the CSC group, but without a statistical difference (P = 0.25). PEDA was significantly smaller in the CSC group than in the non-CSC group (P = 0.03). Conclusion PEDA is an ideal parameter to reflect hydrostatic pressure and stretches for RPE. As PED predisposes to the development of CSC in selected VKH eyes, PEDA may be a valuable predictive factor for the development of classic CSC in VKH cases.https://doi.org/10.1186/s12886-022-02675-6Retinal pigment epithelial detachmentVogt-Koyanagi-Harada diseaseCentral serous chorioretinopathyCorticosteroidSubthreshold micropulse laser photocoagulationPigment epithelial detachment angle |
| spellingShingle | Chuanzhen Zheng Kaixuan Wang Mi Zhang Qingqin Tao Xiaorong Li Xiaomin Zhang Outcomes of retinal pigment epithelial detachment in Vogt-Koyanagi-Harada disease: a longitudinal analysis BMC Ophthalmology Retinal pigment epithelial detachment Vogt-Koyanagi-Harada disease Central serous chorioretinopathy Corticosteroid Subthreshold micropulse laser photocoagulation Pigment epithelial detachment angle |
| title | Outcomes of retinal pigment epithelial detachment in Vogt-Koyanagi-Harada disease: a longitudinal analysis |
| title_full | Outcomes of retinal pigment epithelial detachment in Vogt-Koyanagi-Harada disease: a longitudinal analysis |
| title_fullStr | Outcomes of retinal pigment epithelial detachment in Vogt-Koyanagi-Harada disease: a longitudinal analysis |
| title_full_unstemmed | Outcomes of retinal pigment epithelial detachment in Vogt-Koyanagi-Harada disease: a longitudinal analysis |
| title_short | Outcomes of retinal pigment epithelial detachment in Vogt-Koyanagi-Harada disease: a longitudinal analysis |
| title_sort | outcomes of retinal pigment epithelial detachment in vogt koyanagi harada disease a longitudinal analysis |
| topic | Retinal pigment epithelial detachment Vogt-Koyanagi-Harada disease Central serous chorioretinopathy Corticosteroid Subthreshold micropulse laser photocoagulation Pigment epithelial detachment angle |
| url | https://doi.org/10.1186/s12886-022-02675-6 |
| work_keys_str_mv | AT chuanzhenzheng outcomesofretinalpigmentepithelialdetachmentinvogtkoyanagiharadadiseasealongitudinalanalysis AT kaixuanwang outcomesofretinalpigmentepithelialdetachmentinvogtkoyanagiharadadiseasealongitudinalanalysis AT mizhang outcomesofretinalpigmentepithelialdetachmentinvogtkoyanagiharadadiseasealongitudinalanalysis AT qingqintao outcomesofretinalpigmentepithelialdetachmentinvogtkoyanagiharadadiseasealongitudinalanalysis AT xiaorongli outcomesofretinalpigmentepithelialdetachmentinvogtkoyanagiharadadiseasealongitudinalanalysis AT xiaominzhang outcomesofretinalpigmentepithelialdetachmentinvogtkoyanagiharadadiseasealongitudinalanalysis |