Cerebral Small Vessel Disease: Neuroimaging Features, Biochemical Markers, Influencing Factors, Pathological Mechanism and Treatment
Cerebral small vessel disease (CSVD) is the most common chronic vascular disease involving the whole brain. Great progress has been made in clinical imaging, pathological mechanism, and treatment of CSVD, but many problems remain. Clarifying the current research dilemmas and future development direc...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-06-01
|
Series: | Frontiers in Neurology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.843953/full |
_version_ | 1818211792721018880 |
---|---|
author | Beida Ren Beida Ren Beida Ren Ling Tan Yuebo Song Danxi Li Danxi Li Bingjie Xue Bingjie Xue Xinxing Lai Ying Gao Ying Gao |
author_facet | Beida Ren Beida Ren Beida Ren Ling Tan Yuebo Song Danxi Li Danxi Li Bingjie Xue Bingjie Xue Xinxing Lai Ying Gao Ying Gao |
author_sort | Beida Ren |
collection | DOAJ |
description | Cerebral small vessel disease (CSVD) is the most common chronic vascular disease involving the whole brain. Great progress has been made in clinical imaging, pathological mechanism, and treatment of CSVD, but many problems remain. Clarifying the current research dilemmas and future development direction of CSVD can provide new ideas for both basic and clinical research. In this review, the risk factors, biological markers, pathological mechanisms, and the treatment of CSVD will be systematically illustrated to provide the current research status of CSVD. The future development direction of CSVD will be elucidated by summarizing the research difficulties. |
first_indexed | 2024-12-12T05:38:08Z |
format | Article |
id | doaj.art-3b9246432ecd4e26a2d00400a75eb9d9 |
institution | Directory Open Access Journal |
issn | 1664-2295 |
language | English |
last_indexed | 2024-12-12T05:38:08Z |
publishDate | 2022-06-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Neurology |
spelling | doaj.art-3b9246432ecd4e26a2d00400a75eb9d92022-12-22T00:36:01ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-06-011310.3389/fneur.2022.843953843953Cerebral Small Vessel Disease: Neuroimaging Features, Biochemical Markers, Influencing Factors, Pathological Mechanism and TreatmentBeida Ren0Beida Ren1Beida Ren2Ling Tan3Yuebo Song4Danxi Li5Danxi Li6Bingjie Xue7Bingjie Xue8Xinxing Lai9Ying Gao10Ying Gao11Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaInstitute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, ChinaChinese Medicine Key Research Room of Brain Disorders Syndrome and Treatment of the National Administration of Traditonal Chinese Medicine, Beijing, ChinaDepartment of Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaInstitute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, ChinaChinese Medicine Key Research Room of Brain Disorders Syndrome and Treatment of the National Administration of Traditonal Chinese Medicine, Beijing, ChinaInstitute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, ChinaChinese Medicine Key Research Room of Brain Disorders Syndrome and Treatment of the National Administration of Traditonal Chinese Medicine, Beijing, ChinaInstitute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaInstitute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, ChinaCerebral small vessel disease (CSVD) is the most common chronic vascular disease involving the whole brain. Great progress has been made in clinical imaging, pathological mechanism, and treatment of CSVD, but many problems remain. Clarifying the current research dilemmas and future development direction of CSVD can provide new ideas for both basic and clinical research. In this review, the risk factors, biological markers, pathological mechanisms, and the treatment of CSVD will be systematically illustrated to provide the current research status of CSVD. The future development direction of CSVD will be elucidated by summarizing the research difficulties.https://www.frontiersin.org/articles/10.3389/fneur.2022.843953/fullcerebral small vessel diseaseneuroimagingbiological markerspathological mechanismtreatmentresearch difficulties |
spellingShingle | Beida Ren Beida Ren Beida Ren Ling Tan Yuebo Song Danxi Li Danxi Li Bingjie Xue Bingjie Xue Xinxing Lai Ying Gao Ying Gao Cerebral Small Vessel Disease: Neuroimaging Features, Biochemical Markers, Influencing Factors, Pathological Mechanism and Treatment Frontiers in Neurology cerebral small vessel disease neuroimaging biological markers pathological mechanism treatment research difficulties |
title | Cerebral Small Vessel Disease: Neuroimaging Features, Biochemical Markers, Influencing Factors, Pathological Mechanism and Treatment |
title_full | Cerebral Small Vessel Disease: Neuroimaging Features, Biochemical Markers, Influencing Factors, Pathological Mechanism and Treatment |
title_fullStr | Cerebral Small Vessel Disease: Neuroimaging Features, Biochemical Markers, Influencing Factors, Pathological Mechanism and Treatment |
title_full_unstemmed | Cerebral Small Vessel Disease: Neuroimaging Features, Biochemical Markers, Influencing Factors, Pathological Mechanism and Treatment |
title_short | Cerebral Small Vessel Disease: Neuroimaging Features, Biochemical Markers, Influencing Factors, Pathological Mechanism and Treatment |
title_sort | cerebral small vessel disease neuroimaging features biochemical markers influencing factors pathological mechanism and treatment |
topic | cerebral small vessel disease neuroimaging biological markers pathological mechanism treatment research difficulties |
url | https://www.frontiersin.org/articles/10.3389/fneur.2022.843953/full |
work_keys_str_mv | AT beidaren cerebralsmallvesseldiseaseneuroimagingfeaturesbiochemicalmarkersinfluencingfactorspathologicalmechanismandtreatment AT beidaren cerebralsmallvesseldiseaseneuroimagingfeaturesbiochemicalmarkersinfluencingfactorspathologicalmechanismandtreatment AT beidaren cerebralsmallvesseldiseaseneuroimagingfeaturesbiochemicalmarkersinfluencingfactorspathologicalmechanismandtreatment AT lingtan cerebralsmallvesseldiseaseneuroimagingfeaturesbiochemicalmarkersinfluencingfactorspathologicalmechanismandtreatment AT yuebosong cerebralsmallvesseldiseaseneuroimagingfeaturesbiochemicalmarkersinfluencingfactorspathologicalmechanismandtreatment AT danxili cerebralsmallvesseldiseaseneuroimagingfeaturesbiochemicalmarkersinfluencingfactorspathologicalmechanismandtreatment AT danxili cerebralsmallvesseldiseaseneuroimagingfeaturesbiochemicalmarkersinfluencingfactorspathologicalmechanismandtreatment AT bingjiexue cerebralsmallvesseldiseaseneuroimagingfeaturesbiochemicalmarkersinfluencingfactorspathologicalmechanismandtreatment AT bingjiexue cerebralsmallvesseldiseaseneuroimagingfeaturesbiochemicalmarkersinfluencingfactorspathologicalmechanismandtreatment AT xinxinglai cerebralsmallvesseldiseaseneuroimagingfeaturesbiochemicalmarkersinfluencingfactorspathologicalmechanismandtreatment AT yinggao cerebralsmallvesseldiseaseneuroimagingfeaturesbiochemicalmarkersinfluencingfactorspathologicalmechanismandtreatment AT yinggao cerebralsmallvesseldiseaseneuroimagingfeaturesbiochemicalmarkersinfluencingfactorspathologicalmechanismandtreatment |