Cerebral Small Vessel Disease: Neuroimaging Features, Biochemical Markers, Influencing Factors, Pathological Mechanism and Treatment

Cerebral small vessel disease (CSVD) is the most common chronic vascular disease involving the whole brain. Great progress has been made in clinical imaging, pathological mechanism, and treatment of CSVD, but many problems remain. Clarifying the current research dilemmas and future development direc...

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Main Authors: Beida Ren, Ling Tan, Yuebo Song, Danxi Li, Bingjie Xue, Xinxing Lai, Ying Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Neurology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.843953/full
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author Beida Ren
Beida Ren
Beida Ren
Ling Tan
Yuebo Song
Danxi Li
Danxi Li
Bingjie Xue
Bingjie Xue
Xinxing Lai
Ying Gao
Ying Gao
author_facet Beida Ren
Beida Ren
Beida Ren
Ling Tan
Yuebo Song
Danxi Li
Danxi Li
Bingjie Xue
Bingjie Xue
Xinxing Lai
Ying Gao
Ying Gao
author_sort Beida Ren
collection DOAJ
description Cerebral small vessel disease (CSVD) is the most common chronic vascular disease involving the whole brain. Great progress has been made in clinical imaging, pathological mechanism, and treatment of CSVD, but many problems remain. Clarifying the current research dilemmas and future development direction of CSVD can provide new ideas for both basic and clinical research. In this review, the risk factors, biological markers, pathological mechanisms, and the treatment of CSVD will be systematically illustrated to provide the current research status of CSVD. The future development direction of CSVD will be elucidated by summarizing the research difficulties.
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spelling doaj.art-3b9246432ecd4e26a2d00400a75eb9d92022-12-22T00:36:01ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-06-011310.3389/fneur.2022.843953843953Cerebral Small Vessel Disease: Neuroimaging Features, Biochemical Markers, Influencing Factors, Pathological Mechanism and TreatmentBeida Ren0Beida Ren1Beida Ren2Ling Tan3Yuebo Song4Danxi Li5Danxi Li6Bingjie Xue7Bingjie Xue8Xinxing Lai9Ying Gao10Ying Gao11Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaInstitute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, ChinaChinese Medicine Key Research Room of Brain Disorders Syndrome and Treatment of the National Administration of Traditonal Chinese Medicine, Beijing, ChinaDepartment of Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaInstitute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, ChinaChinese Medicine Key Research Room of Brain Disorders Syndrome and Treatment of the National Administration of Traditonal Chinese Medicine, Beijing, ChinaInstitute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, ChinaChinese Medicine Key Research Room of Brain Disorders Syndrome and Treatment of the National Administration of Traditonal Chinese Medicine, Beijing, ChinaInstitute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaInstitute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, ChinaCerebral small vessel disease (CSVD) is the most common chronic vascular disease involving the whole brain. Great progress has been made in clinical imaging, pathological mechanism, and treatment of CSVD, but many problems remain. Clarifying the current research dilemmas and future development direction of CSVD can provide new ideas for both basic and clinical research. In this review, the risk factors, biological markers, pathological mechanisms, and the treatment of CSVD will be systematically illustrated to provide the current research status of CSVD. The future development direction of CSVD will be elucidated by summarizing the research difficulties.https://www.frontiersin.org/articles/10.3389/fneur.2022.843953/fullcerebral small vessel diseaseneuroimagingbiological markerspathological mechanismtreatmentresearch difficulties
spellingShingle Beida Ren
Beida Ren
Beida Ren
Ling Tan
Yuebo Song
Danxi Li
Danxi Li
Bingjie Xue
Bingjie Xue
Xinxing Lai
Ying Gao
Ying Gao
Cerebral Small Vessel Disease: Neuroimaging Features, Biochemical Markers, Influencing Factors, Pathological Mechanism and Treatment
Frontiers in Neurology
cerebral small vessel disease
neuroimaging
biological markers
pathological mechanism
treatment
research difficulties
title Cerebral Small Vessel Disease: Neuroimaging Features, Biochemical Markers, Influencing Factors, Pathological Mechanism and Treatment
title_full Cerebral Small Vessel Disease: Neuroimaging Features, Biochemical Markers, Influencing Factors, Pathological Mechanism and Treatment
title_fullStr Cerebral Small Vessel Disease: Neuroimaging Features, Biochemical Markers, Influencing Factors, Pathological Mechanism and Treatment
title_full_unstemmed Cerebral Small Vessel Disease: Neuroimaging Features, Biochemical Markers, Influencing Factors, Pathological Mechanism and Treatment
title_short Cerebral Small Vessel Disease: Neuroimaging Features, Biochemical Markers, Influencing Factors, Pathological Mechanism and Treatment
title_sort cerebral small vessel disease neuroimaging features biochemical markers influencing factors pathological mechanism and treatment
topic cerebral small vessel disease
neuroimaging
biological markers
pathological mechanism
treatment
research difficulties
url https://www.frontiersin.org/articles/10.3389/fneur.2022.843953/full
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