P3.29 ASSESSMENT OF THE DETERMINANTS OF LOCAL CAROTID STIFFNESS IN A GENERAL POPULATION IN NORTHERN ITALY
Background: The determinants of aortic stiffness have been elucidated in several studies, while few data are available for carotid stiffness. Aim of the study was to identify the main determinants of carotid arterial stiffness parameters in a general population in Northern-Italy(Vobarno Study). Met...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2013-11-01
|
| Series: | Artery Research |
| Online Access: | https://www.atlantis-press.com/article/125938992/view |
| _version_ | 1818216741116837888 |
|---|---|
| author | C. Aggiusti A. Paini M. Salvetti F. Bertacchini D. Stassaldi C. Agabiti Rosei G. Maruelli G. Rubagotti E. Agabiti Rosei M.L. Muiesan |
| author_facet | C. Aggiusti A. Paini M. Salvetti F. Bertacchini D. Stassaldi C. Agabiti Rosei G. Maruelli G. Rubagotti E. Agabiti Rosei M.L. Muiesan |
| author_sort | C. Aggiusti |
| collection | DOAJ |
| description | Background: The determinants of aortic stiffness have been elucidated in several studies, while few data are available for carotid stiffness. Aim of the study was to identify the main determinants of carotid arterial stiffness parameters in a general population in Northern-Italy(Vobarno Study).
Methods:183subjects(61% female, mean age 55± 4,53% hypertensives,59% treated) underwent laboratory examinations and both clinic and 24 hours BP measurement (Spacelabs 90207). A non-invasive echotracking system was used to measure intima-media thickness, diameter, distension, distensibility (Dist), distensibility coefficient (CDist), compliance coefficient (CC) and elastic modulus (Einc) on 4-cm long common carotid artery segment.
Results: correlation coefficient of Dist, CDist and Einc are shown in Table 1.
Dist
CDist
Einc
R
p
r
p
r
p
Age (years)
−0.240*
0.001
−0.241*
0.001
0.210*
0.005
BMI (Kg/m2)
−0.192*
0.01
−0.192*
0.010
0.169*
0.024
Clinic SBP (mmHg)
−0.501*
0.001
−0.477*
0.000
0.511*
0.000
Clinic DBP (mmHg)
−0.181*
0.015
−0.184*
0.014
0.262*
0.000
Clinic MBP (mmHg)
−0.374*
0.001
−0.362*
0.000
0.422*
0.000
24 hours SBP (mmHg)
−0.207*
0.006
−0.198*
0.009
0.222*
0.003
24 hours DBP (mmHg)
−0.183*
0.016
−0.191*
0.012
0.207*
0.006
24 hours MBP(mmHg)
−0.13
0.094
−0.125
0.099
0.166*
0.029
At multivariate analysis the independent predictor of Dist,CDist and Einc were age (β=−0.22, β=−0.22 and β=0.18, respectively, all p<0.01), BMI (β=−0.18, β=−0.18 and β=0.14, respectively, all p<0.05),MBP (β=−0.34, β=−0.33 and β=0.40, respectively, all p<0.001)and female gender(β=0.19,β=0.18 and β=−0.15,respectively,all p<0.05).When carotid arterial stiffness parameters were compared in males and females,a significantly lower values of Dist and CC were observed in females (365±97 vs 427±124 μm,p<0.001 and 0.63±0.24 vs 0.83±0.29 mm2/kPa−1,p<0.001, respectively).After adjusting for possible confounders in a multivariate model distension(345 vs 456 μm, p<0.001),CDist (23.4 vs 30.3 kPa−1*10−3, p<0.001) and CC (0.61 vs 0.87 mm2/kPa−1, p<0.001)were significantly lower in females while Einc was significantly higher in females(0.45 vs 0.34 kPa*103,p=0.007).Conclusion: in a general population sample age, female gender, BMI and clinic and 24 hours BP values are associated to an increase local carotid stiffness. |
| first_indexed | 2024-12-12T06:56:47Z |
| format | Article |
| id | doaj.art-3b93469baf3c4948ac711854ffee388e |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-12-12T06:56:47Z |
| publishDate | 2013-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-3b93469baf3c4948ac711854ffee388e2022-12-22T00:33:56ZengBMCArtery Research1876-44012013-11-0171010.1016/j.artres.2013.10.116P3.29 ASSESSMENT OF THE DETERMINANTS OF LOCAL CAROTID STIFFNESS IN A GENERAL POPULATION IN NORTHERN ITALYC. AggiustiA. PainiM. SalvettiF. BertacchiniD. StassaldiC. Agabiti RoseiG. MaruelliG. RubagottiE. Agabiti RoseiM.L. MuiesanBackground: The determinants of aortic stiffness have been elucidated in several studies, while few data are available for carotid stiffness. Aim of the study was to identify the main determinants of carotid arterial stiffness parameters in a general population in Northern-Italy(Vobarno Study). Methods:183subjects(61% female, mean age 55± 4,53% hypertensives,59% treated) underwent laboratory examinations and both clinic and 24 hours BP measurement (Spacelabs 90207). A non-invasive echotracking system was used to measure intima-media thickness, diameter, distension, distensibility (Dist), distensibility coefficient (CDist), compliance coefficient (CC) and elastic modulus (Einc) on 4-cm long common carotid artery segment. Results: correlation coefficient of Dist, CDist and Einc are shown in Table 1. Dist CDist Einc R p r p r p Age (years) −0.240* 0.001 −0.241* 0.001 0.210* 0.005 BMI (Kg/m2) −0.192* 0.01 −0.192* 0.010 0.169* 0.024 Clinic SBP (mmHg) −0.501* 0.001 −0.477* 0.000 0.511* 0.000 Clinic DBP (mmHg) −0.181* 0.015 −0.184* 0.014 0.262* 0.000 Clinic MBP (mmHg) −0.374* 0.001 −0.362* 0.000 0.422* 0.000 24 hours SBP (mmHg) −0.207* 0.006 −0.198* 0.009 0.222* 0.003 24 hours DBP (mmHg) −0.183* 0.016 −0.191* 0.012 0.207* 0.006 24 hours MBP(mmHg) −0.13 0.094 −0.125 0.099 0.166* 0.029 At multivariate analysis the independent predictor of Dist,CDist and Einc were age (β=−0.22, β=−0.22 and β=0.18, respectively, all p<0.01), BMI (β=−0.18, β=−0.18 and β=0.14, respectively, all p<0.05),MBP (β=−0.34, β=−0.33 and β=0.40, respectively, all p<0.001)and female gender(β=0.19,β=0.18 and β=−0.15,respectively,all p<0.05).When carotid arterial stiffness parameters were compared in males and females,a significantly lower values of Dist and CC were observed in females (365±97 vs 427±124 μm,p<0.001 and 0.63±0.24 vs 0.83±0.29 mm2/kPa−1,p<0.001, respectively).After adjusting for possible confounders in a multivariate model distension(345 vs 456 μm, p<0.001),CDist (23.4 vs 30.3 kPa−1*10−3, p<0.001) and CC (0.61 vs 0.87 mm2/kPa−1, p<0.001)were significantly lower in females while Einc was significantly higher in females(0.45 vs 0.34 kPa*103,p=0.007).Conclusion: in a general population sample age, female gender, BMI and clinic and 24 hours BP values are associated to an increase local carotid stiffness.https://www.atlantis-press.com/article/125938992/view |
| spellingShingle | C. Aggiusti A. Paini M. Salvetti F. Bertacchini D. Stassaldi C. Agabiti Rosei G. Maruelli G. Rubagotti E. Agabiti Rosei M.L. Muiesan P3.29 ASSESSMENT OF THE DETERMINANTS OF LOCAL CAROTID STIFFNESS IN A GENERAL POPULATION IN NORTHERN ITALY Artery Research |
| title | P3.29 ASSESSMENT OF THE DETERMINANTS OF LOCAL CAROTID STIFFNESS IN A GENERAL POPULATION IN NORTHERN ITALY |
| title_full | P3.29 ASSESSMENT OF THE DETERMINANTS OF LOCAL CAROTID STIFFNESS IN A GENERAL POPULATION IN NORTHERN ITALY |
| title_fullStr | P3.29 ASSESSMENT OF THE DETERMINANTS OF LOCAL CAROTID STIFFNESS IN A GENERAL POPULATION IN NORTHERN ITALY |
| title_full_unstemmed | P3.29 ASSESSMENT OF THE DETERMINANTS OF LOCAL CAROTID STIFFNESS IN A GENERAL POPULATION IN NORTHERN ITALY |
| title_short | P3.29 ASSESSMENT OF THE DETERMINANTS OF LOCAL CAROTID STIFFNESS IN A GENERAL POPULATION IN NORTHERN ITALY |
| title_sort | p3 29 assessment of the determinants of local carotid stiffness in a general population in northern italy |
| url | https://www.atlantis-press.com/article/125938992/view |
| work_keys_str_mv | AT caggiusti p329assessmentofthedeterminantsoflocalcarotidstiffnessinageneralpopulationinnorthernitaly AT apaini p329assessmentofthedeterminantsoflocalcarotidstiffnessinageneralpopulationinnorthernitaly AT msalvetti p329assessmentofthedeterminantsoflocalcarotidstiffnessinageneralpopulationinnorthernitaly AT fbertacchini p329assessmentofthedeterminantsoflocalcarotidstiffnessinageneralpopulationinnorthernitaly AT dstassaldi p329assessmentofthedeterminantsoflocalcarotidstiffnessinageneralpopulationinnorthernitaly AT cagabitirosei p329assessmentofthedeterminantsoflocalcarotidstiffnessinageneralpopulationinnorthernitaly AT gmaruelli p329assessmentofthedeterminantsoflocalcarotidstiffnessinageneralpopulationinnorthernitaly AT grubagotti p329assessmentofthedeterminantsoflocalcarotidstiffnessinageneralpopulationinnorthernitaly AT eagabitirosei p329assessmentofthedeterminantsoflocalcarotidstiffnessinageneralpopulationinnorthernitaly AT mlmuiesan p329assessmentofthedeterminantsoflocalcarotidstiffnessinageneralpopulationinnorthernitaly |