New Perspective on the Geographic Distribution and Evolution of Lymphocytic Choriomeningitis Virus, Central Europe
Lymphocytic choriomeningitis virus (LCMV) is an Old World mammarenavirus found worldwide because of its association with the house mouse. When LCMV spills over to immunocompetent humans, the virus can cause aseptic meningitis; in immunocompromised persons, systemic infection and death can occur. Cen...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2021-10-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/27/10/21-0224_article |
| _version_ | 1824021266286247936 |
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| author | Alena Fornůsková Zuzana Hiadlovská Miloš Macholán Jaroslav Piálek Joëlle Goüy de Bellocq |
| author_facet | Alena Fornůsková Zuzana Hiadlovská Miloš Macholán Jaroslav Piálek Joëlle Goüy de Bellocq |
| author_sort | Alena Fornůsková |
| collection | DOAJ |
| description | Lymphocytic choriomeningitis virus (LCMV) is an Old World mammarenavirus found worldwide because of its association with the house mouse. When LCMV spills over to immunocompetent humans, the virus can cause aseptic meningitis; in immunocompromised persons, systemic infection and death can occur. Central Europe is a strategic location for the study of LCMV evolutionary history and host specificity because of the presence of a hybrid zone (genetic barrier) between 2 house mouse subspecies, Mus musculus musculus and M. musculus domesticus. We report LCMV prevalence in natural mouse populations from a Czech Republic–Germany transect and genomic characterization of 2 new LCMV variants from the Czech Republic. We demonstrate that the main division in the LCMV phylogenetic tree corresponds to mouse host subspecies and, when the virus is found in human hosts, the mouse subspecies found at the spillover location. Therefore, LCMV strains infecting humans can be predicted by the genetic structure of house mice. |
| first_indexed | 2024-12-19T01:42:47Z |
| format | Article |
| id | doaj.art-3b935945c4f647b4a36405ce7fa8504f |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-19T01:42:47Z |
| publishDate | 2021-10-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-3b935945c4f647b4a36405ce7fa8504f2022-12-21T20:41:43ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592021-10-0127102638264710.3201/eid2710.210224New Perspective on the Geographic Distribution and Evolution of Lymphocytic Choriomeningitis Virus, Central EuropeAlena FornůskováZuzana HiadlovskáMiloš MacholánJaroslav PiálekJoëlle Goüy de BellocqLymphocytic choriomeningitis virus (LCMV) is an Old World mammarenavirus found worldwide because of its association with the house mouse. When LCMV spills over to immunocompetent humans, the virus can cause aseptic meningitis; in immunocompromised persons, systemic infection and death can occur. Central Europe is a strategic location for the study of LCMV evolutionary history and host specificity because of the presence of a hybrid zone (genetic barrier) between 2 house mouse subspecies, Mus musculus musculus and M. musculus domesticus. We report LCMV prevalence in natural mouse populations from a Czech Republic–Germany transect and genomic characterization of 2 new LCMV variants from the Czech Republic. We demonstrate that the main division in the LCMV phylogenetic tree corresponds to mouse host subspecies and, when the virus is found in human hosts, the mouse subspecies found at the spillover location. Therefore, LCMV strains infecting humans can be predicted by the genetic structure of house mice.https://wwwnc.cdc.gov/eid/article/27/10/21-0224_articleviruseslymphocytic choriomeningitis viruscentral EuropeMus musculus musculusMus musculus domesticuszoonoses |
| spellingShingle | Alena Fornůsková Zuzana Hiadlovská Miloš Macholán Jaroslav Piálek Joëlle Goüy de Bellocq New Perspective on the Geographic Distribution and Evolution of Lymphocytic Choriomeningitis Virus, Central Europe Emerging Infectious Diseases viruses lymphocytic choriomeningitis virus central Europe Mus musculus musculus Mus musculus domesticus zoonoses |
| title | New Perspective on the Geographic Distribution and Evolution of Lymphocytic Choriomeningitis Virus, Central Europe |
| title_full | New Perspective on the Geographic Distribution and Evolution of Lymphocytic Choriomeningitis Virus, Central Europe |
| title_fullStr | New Perspective on the Geographic Distribution and Evolution of Lymphocytic Choriomeningitis Virus, Central Europe |
| title_full_unstemmed | New Perspective on the Geographic Distribution and Evolution of Lymphocytic Choriomeningitis Virus, Central Europe |
| title_short | New Perspective on the Geographic Distribution and Evolution of Lymphocytic Choriomeningitis Virus, Central Europe |
| title_sort | new perspective on the geographic distribution and evolution of lymphocytic choriomeningitis virus central europe |
| topic | viruses lymphocytic choriomeningitis virus central Europe Mus musculus musculus Mus musculus domesticus zoonoses |
| url | https://wwwnc.cdc.gov/eid/article/27/10/21-0224_article |
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