Saccadic performance and cortical excitability as trait-markers and state-markers in rapid-cycling bipolar disorder: a 2-case follow-up study.
Background: The understanding of physiopathology and cognitive impairments in mood disorders requires finding objective markers. Mood disorders have often been linked to hypometabolism in the prefrontal dorsolateral cortex, and to GABAergic and glutamatergic neurotransmission dysfunction. The presen...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-01-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpsyt.2012.00112/full |
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| author | Jennifer eMalsert Nathalie eGuyader Alan eChauvin Mircea ePolosan Mircea ePolosan David eSzekely David eSzekely Thierry eBougerol Thierry eBougerol Christian eMarendaz |
| author_facet | Jennifer eMalsert Nathalie eGuyader Alan eChauvin Mircea ePolosan Mircea ePolosan David eSzekely David eSzekely Thierry eBougerol Thierry eBougerol Christian eMarendaz |
| author_sort | Jennifer eMalsert |
| collection | DOAJ |
| description | Background: The understanding of physiopathology and cognitive impairments in mood disorders requires finding objective markers. Mood disorders have often been linked to hypometabolism in the prefrontal dorsolateral cortex, and to GABAergic and glutamatergic neurotransmission dysfunction. The present study aimed to discover whether saccadic tasks (involving DPLFC activity), and cortical excitability (involving GABA/Glutamate neurotransmission) could provide neuropsychophysical markers for mood disorders, and/or of its phases, in patients with rapid-cycling bipolar disorders (rcBD). Methods: Two rcBD patients were followed for a cycle, and were compared to 9 healthy controls. A saccade task, mixing prosaccades, antisaccades and nosaccades, and an evaluation of cortical excitability using transcranial magnetic stimulation were performed. Results: We observed a deficit in antisaccade in patients independently of thymic phase, and in nosaccade in the manic phase only. Cortical excitability data revealed global intracortical deficits in all phases, switching according to cerebral hemisphere and thymic phase. Conclusion: Specific patterns of performance in saccade tasks and cortical excitability could characterize mood disorders (trait-markers) and its phases (state-markers). Moreover, a functional relationship between oculometric performance and cortical excitability is discussed. |
| first_indexed | 2024-12-14T00:46:54Z |
| format | Article |
| id | doaj.art-3b942071bb00452b8770322f2439f466 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-14T00:46:54Z |
| publishDate | 2013-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-3b942071bb00452b8770322f2439f4662022-12-21T23:24:04ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402013-01-01310.3389/fpsyt.2012.0011236618Saccadic performance and cortical excitability as trait-markers and state-markers in rapid-cycling bipolar disorder: a 2-case follow-up study.Jennifer eMalsert0Nathalie eGuyader1Alan eChauvin2Mircea ePolosan3Mircea ePolosan4David eSzekely5David eSzekely6Thierry eBougerol7Thierry eBougerol8Christian eMarendaz9Université de GrenobleGIPSA-labUniversité de GrenobleCentre Hospitalier Universitaire GrenobleGrenoble Institut des Neurosciences (GIN)Centre Hospitalier Universitaire GrenobleGrenoble Institut des Neurosciences (GIN)Centre Hospitalier Universitaire GrenobleUniversité de GrenobleUniversité de GrenobleBackground: The understanding of physiopathology and cognitive impairments in mood disorders requires finding objective markers. Mood disorders have often been linked to hypometabolism in the prefrontal dorsolateral cortex, and to GABAergic and glutamatergic neurotransmission dysfunction. The present study aimed to discover whether saccadic tasks (involving DPLFC activity), and cortical excitability (involving GABA/Glutamate neurotransmission) could provide neuropsychophysical markers for mood disorders, and/or of its phases, in patients with rapid-cycling bipolar disorders (rcBD). Methods: Two rcBD patients were followed for a cycle, and were compared to 9 healthy controls. A saccade task, mixing prosaccades, antisaccades and nosaccades, and an evaluation of cortical excitability using transcranial magnetic stimulation were performed. Results: We observed a deficit in antisaccade in patients independently of thymic phase, and in nosaccade in the manic phase only. Cortical excitability data revealed global intracortical deficits in all phases, switching according to cerebral hemisphere and thymic phase. Conclusion: Specific patterns of performance in saccade tasks and cortical excitability could characterize mood disorders (trait-markers) and its phases (state-markers). Moreover, a functional relationship between oculometric performance and cortical excitability is discussed.http://journal.frontiersin.org/Journal/10.3389/fpsyt.2012.00112/fullsaccadeTMSantisaccadecortical excitabilitypaired-pulseinhibition / facilitation |
| spellingShingle | Jennifer eMalsert Nathalie eGuyader Alan eChauvin Mircea ePolosan Mircea ePolosan David eSzekely David eSzekely Thierry eBougerol Thierry eBougerol Christian eMarendaz Saccadic performance and cortical excitability as trait-markers and state-markers in rapid-cycling bipolar disorder: a 2-case follow-up study. Frontiers in Psychiatry saccade TMS antisaccade cortical excitability paired-pulse inhibition / facilitation |
| title | Saccadic performance and cortical excitability as trait-markers and state-markers in rapid-cycling bipolar disorder: a 2-case follow-up study. |
| title_full | Saccadic performance and cortical excitability as trait-markers and state-markers in rapid-cycling bipolar disorder: a 2-case follow-up study. |
| title_fullStr | Saccadic performance and cortical excitability as trait-markers and state-markers in rapid-cycling bipolar disorder: a 2-case follow-up study. |
| title_full_unstemmed | Saccadic performance and cortical excitability as trait-markers and state-markers in rapid-cycling bipolar disorder: a 2-case follow-up study. |
| title_short | Saccadic performance and cortical excitability as trait-markers and state-markers in rapid-cycling bipolar disorder: a 2-case follow-up study. |
| title_sort | saccadic performance and cortical excitability as trait markers and state markers in rapid cycling bipolar disorder a 2 case follow up study |
| topic | saccade TMS antisaccade cortical excitability paired-pulse inhibition / facilitation |
| url | http://journal.frontiersin.org/Journal/10.3389/fpsyt.2012.00112/full |
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