Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms
In the post-antibiotic era, the rapid development of antibiotic resistance and the shortage of available antibiotics are triggering a new health-care crisis. The discovery of novel and potent antibiotics to extend the antibiotic pipeline is urgent. Small-molecule antimicrobial peptides have a wide v...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/21/10/547 |
| _version_ | 1827720513616609280 |
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| author | Wei Wang Liting Gu Jiahao Wang Xubin Hu Bin Wei Huawei Zhang Hong Wang Jianwei Chen |
| author_facet | Wei Wang Liting Gu Jiahao Wang Xubin Hu Bin Wei Huawei Zhang Hong Wang Jianwei Chen |
| author_sort | Wei Wang |
| collection | DOAJ |
| description | In the post-antibiotic era, the rapid development of antibiotic resistance and the shortage of available antibiotics are triggering a new health-care crisis. The discovery of novel and potent antibiotics to extend the antibiotic pipeline is urgent. Small-molecule antimicrobial peptides have a wide variety of antimicrobial spectra and multiple innovative antimicrobial mechanisms due to their rich structural diversity. Consequently, they have become a new research hotspot and are considered to be promising candidates for next-generation antibiotics. Therefore, we have compiled a collection of small-molecule antimicrobial peptides derived from marine microorganisms from the last fifteen years to show the recent advances in this field. We categorize these compounds into three classes—cyclic oligopeptides, cyclic depsipeptides, and cyclic lipopeptides—according to their structural features, and present their sources, structures, and antimicrobial spectrums, with a discussion of the structure activity relationships and mechanisms of action of some compounds. |
| first_indexed | 2024-03-10T21:05:36Z |
| format | Article |
| id | doaj.art-3b956ed5935b46e6919c68c38dcdc713 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T21:05:36Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-3b956ed5935b46e6919c68c38dcdc7132023-11-19T17:09:47ZengMDPI AGMarine Drugs1660-33972023-10-01211054710.3390/md21100547Recent Advances in Polypeptide Antibiotics Derived from Marine MicroorganismsWei Wang0Liting Gu1Jiahao Wang2Xubin Hu3Bin Wei4Huawei Zhang5Hong Wang6Jianwei Chen7Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education & Key Laboratory Pharmaceutical Engineering of Zhejiang Province & College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaKey Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education & Key Laboratory Pharmaceutical Engineering of Zhejiang Province & College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaKey Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education & Key Laboratory Pharmaceutical Engineering of Zhejiang Province & College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaKey Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education & Key Laboratory Pharmaceutical Engineering of Zhejiang Province & College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaKey Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education & Key Laboratory Pharmaceutical Engineering of Zhejiang Province & College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaKey Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education & Key Laboratory Pharmaceutical Engineering of Zhejiang Province & College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaKey Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education & Key Laboratory Pharmaceutical Engineering of Zhejiang Province & College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaKey Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education & Key Laboratory Pharmaceutical Engineering of Zhejiang Province & College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaIn the post-antibiotic era, the rapid development of antibiotic resistance and the shortage of available antibiotics are triggering a new health-care crisis. The discovery of novel and potent antibiotics to extend the antibiotic pipeline is urgent. Small-molecule antimicrobial peptides have a wide variety of antimicrobial spectra and multiple innovative antimicrobial mechanisms due to their rich structural diversity. Consequently, they have become a new research hotspot and are considered to be promising candidates for next-generation antibiotics. Therefore, we have compiled a collection of small-molecule antimicrobial peptides derived from marine microorganisms from the last fifteen years to show the recent advances in this field. We categorize these compounds into three classes—cyclic oligopeptides, cyclic depsipeptides, and cyclic lipopeptides—according to their structural features, and present their sources, structures, and antimicrobial spectrums, with a discussion of the structure activity relationships and mechanisms of action of some compounds.https://www.mdpi.com/1660-3397/21/10/547antimicrobial activitydepsipeptideslipopeptidesoligopeptidesantibiotic resistance |
| spellingShingle | Wei Wang Liting Gu Jiahao Wang Xubin Hu Bin Wei Huawei Zhang Hong Wang Jianwei Chen Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms Marine Drugs antimicrobial activity depsipeptides lipopeptides oligopeptides antibiotic resistance |
| title | Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms |
| title_full | Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms |
| title_fullStr | Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms |
| title_full_unstemmed | Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms |
| title_short | Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms |
| title_sort | recent advances in polypeptide antibiotics derived from marine microorganisms |
| topic | antimicrobial activity depsipeptides lipopeptides oligopeptides antibiotic resistance |
| url | https://www.mdpi.com/1660-3397/21/10/547 |
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