Does the Metabolome of Wild-like <i>Dendrobium officinale</i> of Different Origins Have Regional Differences?
<i>Dendrobium officinale</i>, as a traditional Chinese medicine, has considerable commercial value and pharmacological activity. Environmental factors of different origins have a great influence on <i>Dendrobium officinale</i> metabolites, which affect its pharmacological act...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/20/7024 |
| _version_ | 1827648583161085952 |
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| author | Qiqian Lan Chenxing Liu Zhanghua Wu Chen Ni Jinyan Li Chunlei Huang Huan Wang Gang Wei |
| author_facet | Qiqian Lan Chenxing Liu Zhanghua Wu Chen Ni Jinyan Li Chunlei Huang Huan Wang Gang Wei |
| author_sort | Qiqian Lan |
| collection | DOAJ |
| description | <i>Dendrobium officinale</i>, as a traditional Chinese medicine, has considerable commercial value and pharmacological activity. Environmental factors of different origins have a great influence on <i>Dendrobium officinale</i> metabolites, which affect its pharmacological activity. This study sought to identify the differential metabolites of wild-imitating cultivated <i>D. officinale</i> stems of different origins. Using the widely-targeted metabolomics approach, 442 metabolites were detected and characterized, including flavonoids, lipids, amino acids and derivatives, and alkaloids. We found that although the chemical constitution of <i>D. officinale</i> cultured in the three habitats was parallel, the contents were significantly different. Meanwhile, the KEGG pathway enrichment analysis revealed that the distinctive metabolites among the three groups were mainly involved in flavone and flavonol biosynthesis. To further explore the different contents of flavonoids, HPLC was performed on four main flavonoid contents, which can be used as one of the references to distinguish <i>D. officinale</i> from different growing origins. In conclusion, a comprehensive profile of the metabolic differences of <i>D. officinale</i> grown in different origins was provided, which contributed a scientific basis for further research on the quality evaluation of <i>D. officinale</i>. |
| first_indexed | 2024-03-09T19:41:12Z |
| format | Article |
| id | doaj.art-3b95cbb24de2450ab7b8ff8c353993b2 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T19:41:12Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-3b95cbb24de2450ab7b8ff8c353993b22023-11-24T01:35:51ZengMDPI AGMolecules1420-30492022-10-012720702410.3390/molecules27207024Does the Metabolome of Wild-like <i>Dendrobium officinale</i> of Different Origins Have Regional Differences?Qiqian Lan0Chenxing Liu1Zhanghua Wu2Chen Ni3Jinyan Li4Chunlei Huang5Huan Wang6Gang Wei7School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaShaoguan Institute of Danxia Dendrobium Officinale, Shaoguan 512005, ChinaSchool of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaSchool of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaSchool of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaSchool of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaSchool of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaSchool of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China<i>Dendrobium officinale</i>, as a traditional Chinese medicine, has considerable commercial value and pharmacological activity. Environmental factors of different origins have a great influence on <i>Dendrobium officinale</i> metabolites, which affect its pharmacological activity. This study sought to identify the differential metabolites of wild-imitating cultivated <i>D. officinale</i> stems of different origins. Using the widely-targeted metabolomics approach, 442 metabolites were detected and characterized, including flavonoids, lipids, amino acids and derivatives, and alkaloids. We found that although the chemical constitution of <i>D. officinale</i> cultured in the three habitats was parallel, the contents were significantly different. Meanwhile, the KEGG pathway enrichment analysis revealed that the distinctive metabolites among the three groups were mainly involved in flavone and flavonol biosynthesis. To further explore the different contents of flavonoids, HPLC was performed on four main flavonoid contents, which can be used as one of the references to distinguish <i>D. officinale</i> from different growing origins. In conclusion, a comprehensive profile of the metabolic differences of <i>D. officinale</i> grown in different origins was provided, which contributed a scientific basis for further research on the quality evaluation of <i>D. officinale</i>.https://www.mdpi.com/1420-3049/27/20/7024<i>Dendrobium officinale</i>widely targeted metabolomicsdifferent originsflavonoids |
| spellingShingle | Qiqian Lan Chenxing Liu Zhanghua Wu Chen Ni Jinyan Li Chunlei Huang Huan Wang Gang Wei Does the Metabolome of Wild-like <i>Dendrobium officinale</i> of Different Origins Have Regional Differences? Molecules <i>Dendrobium officinale</i> widely targeted metabolomics different origins flavonoids |
| title | Does the Metabolome of Wild-like <i>Dendrobium officinale</i> of Different Origins Have Regional Differences? |
| title_full | Does the Metabolome of Wild-like <i>Dendrobium officinale</i> of Different Origins Have Regional Differences? |
| title_fullStr | Does the Metabolome of Wild-like <i>Dendrobium officinale</i> of Different Origins Have Regional Differences? |
| title_full_unstemmed | Does the Metabolome of Wild-like <i>Dendrobium officinale</i> of Different Origins Have Regional Differences? |
| title_short | Does the Metabolome of Wild-like <i>Dendrobium officinale</i> of Different Origins Have Regional Differences? |
| title_sort | does the metabolome of wild like i dendrobium officinale i of different origins have regional differences |
| topic | <i>Dendrobium officinale</i> widely targeted metabolomics different origins flavonoids |
| url | https://www.mdpi.com/1420-3049/27/20/7024 |
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