Circular RNA encoded MET variant promotes glioblastoma tumorigenesis

Circular RNA encoded MET variant promotes glioblastoma tumorigenesis

Abstract Activated by its single ligand, hepatocyte growth factor (HGF), the receptor tyrosine kinase MET is pivotal in promoting glioblastoma (GBM) stem cell self-renewal, invasiveness and tumorigenicity. Nevertheless, HGF/MET-targeted therapy has shown limited clinical benefits in GBM patients, su...

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Bibliographic Details
Main Authors: Jian Zhong, Xujia Wu, Yixin Gao, Junju Chen, Maolei Zhang, Huangkai Zhou, Jia Yang, Feizhe Xiao, Xuesong Yang, Nunu Huang, Haoyue Qi, Xiuxing Wang, Fan Bai, Yu Shi, Nu Zhang
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40212-1

Internet

https://doi.org/10.1038/s41467-023-40212-1

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