Association between endoscopic findings and histopathological confirmation in patients with suspicion of eosinophilic esophagitis
ABSTRACT BACKGROUND: The diagnosis of eosinophilic esophagitis (EoE) is performed by the detection of 15 or more eosinophils per field in an esophageal biopsy sample, but the endoscopic findings alone are not validated for a diagnosis of the disease. OBJECTIVE: To evaluate the association betwee...
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Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)
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| Series: | Arquivos de Gastroenterologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032019000200151&lng=en&tlng=en |
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| author | João Paulo Cândido BARBOSA Paulo Roberto Veras TAVARES Priscilla Mariana Freitas AGUIAR Luciano Monteiro FRANCO Miguel Ângelo NOBRE-e-SOUZA Marcellus Henrique Loiola Ponte SOUZA |
| author_facet | João Paulo Cândido BARBOSA Paulo Roberto Veras TAVARES Priscilla Mariana Freitas AGUIAR Luciano Monteiro FRANCO Miguel Ângelo NOBRE-e-SOUZA Marcellus Henrique Loiola Ponte SOUZA |
| author_sort | João Paulo Cândido BARBOSA |
| collection | DOAJ |
| description | ABSTRACT BACKGROUND: The diagnosis of eosinophilic esophagitis (EoE) is performed by the detection of 15 or more eosinophils per field in an esophageal biopsy sample, but the endoscopic findings alone are not validated for a diagnosis of the disease. OBJECTIVE: To evaluate the association between the endoscopic findings and histopathological diagnosis in patients with suspected EoE in endoscopy. METHODS: A retrospective study of 24 patients with suspicion of EoE during endoscopy was held. The information was collected from databases of Endoscopy and Pathology services of the Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, from March 2012 to April 2018. The patients were divided into a group with positive biopsy (>15 Eosinophils/field, N=8) and a group with negative biopsy (<15 Eosinophils/field, N=16), and the endoscopic findings were compared between the two groups. RESULTS: From a total of 24 patients, 79.1% had longitudinal grooves, 20.8% white exudates, 33.3% mucosal pallor or loss of vascularity and 45.8% had more than one endoscopic finding. There was a significant difference (P<0.05) in the evaluation of the finding of mucosal pallor or decreased vasculature alone among the groups. The positive predictive value and negative predictive value of the presence of more than one endoscopic findings for the diagnosis of EoE was 54% and 84%, respectively. CONCLUSION: There was a low association between the presence of endoscopic findings and histopathological confirmation of the disease, which indicates that endoscopic findings alone are not reliable for the diagnosis of EoE. |
| first_indexed | 2024-12-20T03:33:28Z |
| format | Article |
| id | doaj.art-3b979b9148ed4d2abf312b3710f04ae1 |
| institution | Directory Open Access Journal |
| issn | 1678-4219 |
| language | English |
| last_indexed | 2024-12-20T03:33:28Z |
| publisher | Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE) |
| record_format | Article |
| series | Arquivos de Gastroenterologia |
| spelling | doaj.art-3b979b9148ed4d2abf312b3710f04ae12022-12-21T19:54:55ZengInstituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)Arquivos de Gastroenterologia1678-421956215115410.1590/s0004-2803.201900000-30S0004-28032019000200151Association between endoscopic findings and histopathological confirmation in patients with suspicion of eosinophilic esophagitisJoão Paulo Cândido BARBOSAPaulo Roberto Veras TAVARESPriscilla Mariana Freitas AGUIARLuciano Monteiro FRANCOMiguel Ângelo NOBRE-e-SOUZAMarcellus Henrique Loiola Ponte SOUZAABSTRACT BACKGROUND: The diagnosis of eosinophilic esophagitis (EoE) is performed by the detection of 15 or more eosinophils per field in an esophageal biopsy sample, but the endoscopic findings alone are not validated for a diagnosis of the disease. OBJECTIVE: To evaluate the association between the endoscopic findings and histopathological diagnosis in patients with suspected EoE in endoscopy. METHODS: A retrospective study of 24 patients with suspicion of EoE during endoscopy was held. The information was collected from databases of Endoscopy and Pathology services of the Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, from March 2012 to April 2018. The patients were divided into a group with positive biopsy (>15 Eosinophils/field, N=8) and a group with negative biopsy (<15 Eosinophils/field, N=16), and the endoscopic findings were compared between the two groups. RESULTS: From a total of 24 patients, 79.1% had longitudinal grooves, 20.8% white exudates, 33.3% mucosal pallor or loss of vascularity and 45.8% had more than one endoscopic finding. There was a significant difference (P<0.05) in the evaluation of the finding of mucosal pallor or decreased vasculature alone among the groups. The positive predictive value and negative predictive value of the presence of more than one endoscopic findings for the diagnosis of EoE was 54% and 84%, respectively. CONCLUSION: There was a low association between the presence of endoscopic findings and histopathological confirmation of the disease, which indicates that endoscopic findings alone are not reliable for the diagnosis of EoE.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032019000200151&lng=en&tlng=enEsofagite eosinofílicaDoenças do esôfagoEosinófilos |
| spellingShingle | João Paulo Cândido BARBOSA Paulo Roberto Veras TAVARES Priscilla Mariana Freitas AGUIAR Luciano Monteiro FRANCO Miguel Ângelo NOBRE-e-SOUZA Marcellus Henrique Loiola Ponte SOUZA Association between endoscopic findings and histopathological confirmation in patients with suspicion of eosinophilic esophagitis Arquivos de Gastroenterologia Esofagite eosinofílica Doenças do esôfago Eosinófilos |
| title | Association between endoscopic findings and histopathological confirmation in patients with suspicion of eosinophilic esophagitis |
| title_full | Association between endoscopic findings and histopathological confirmation in patients with suspicion of eosinophilic esophagitis |
| title_fullStr | Association between endoscopic findings and histopathological confirmation in patients with suspicion of eosinophilic esophagitis |
| title_full_unstemmed | Association between endoscopic findings and histopathological confirmation in patients with suspicion of eosinophilic esophagitis |
| title_short | Association between endoscopic findings and histopathological confirmation in patients with suspicion of eosinophilic esophagitis |
| title_sort | association between endoscopic findings and histopathological confirmation in patients with suspicion of eosinophilic esophagitis |
| topic | Esofagite eosinofílica Doenças do esôfago Eosinófilos |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032019000200151&lng=en&tlng=en |
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