Bidirectional Mendelian randomization study of psychiatric disorders and Parkinson’s disease
IntroductionAlthough the relationship between psychiatric disorders and Parkinson’s disease (PD) has attracted continuous research attention, the causal linkage between them has not reached a definite conclusion.MethodsTo identify the causal relationship between psychiatric disorders and PD, we used...
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1120615/full |
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| author | Qi Wu Qi Wu Shulin Liu Xiurong Huang Jiabin Liu Yige Wang Yaqing Xiang Xuxiong Tang Xuxiong Tang Qian Xu Qian Xu Qian Xu Qian Xu Qian Xu Qian Xu Xinxiang Yan Xinxiang Yan Xinxiang Yan Xinxiang Yan Xinxiang Yan Beisha Tang Beisha Tang Beisha Tang Beisha Tang Beisha Tang Jifeng Guo Jifeng Guo Jifeng Guo Jifeng Guo Jifeng Guo Jifeng Guo |
| author_facet | Qi Wu Qi Wu Shulin Liu Xiurong Huang Jiabin Liu Yige Wang Yaqing Xiang Xuxiong Tang Xuxiong Tang Qian Xu Qian Xu Qian Xu Qian Xu Qian Xu Qian Xu Xinxiang Yan Xinxiang Yan Xinxiang Yan Xinxiang Yan Xinxiang Yan Beisha Tang Beisha Tang Beisha Tang Beisha Tang Beisha Tang Jifeng Guo Jifeng Guo Jifeng Guo Jifeng Guo Jifeng Guo Jifeng Guo |
| author_sort | Qi Wu |
| collection | DOAJ |
| description | IntroductionAlthough the relationship between psychiatric disorders and Parkinson’s disease (PD) has attracted continuous research attention, the causal linkage between them has not reached a definite conclusion.MethodsTo identify the causal relationship between psychiatric disorders and PD, we used public summary-level data from the most recent and largest genome-wide association studies (GWASs) on psychiatric disorders and PD to conduct a bidirectional two-sample Mendelian randomization (MR). We applied stringent control steps in instrumental variable selection using the Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) method to rule out pleiotropy. The inverse-variance weighted (IVW) method was used to identify the causal relationship between psychiatric disorders and PD. Multiple MR analysis methods, including MR-Egger, weighted-median, and leave-one-out analyses, were used for sensitivity analysis, followed by heterogeneity tests. Further validation and reverse MR analyses were conducted to strengthen the results of the forward MR analysis.ResultsThe lack of sufficient estimation results could suggest a causal relationship between psychiatric disorders and PD in the forward MR analysis. However, the subsequent reverse MR analysis detected a causal relationship between PD and bipolar disorder (IVW: odds ratios [OR] =1.053, 95% confidence interval [CI] =1.02–1.09, p = 0.001). Further analysis demonstrated a causal relationship between genetically predicted PD and the risk of bipolar disorder subtype. No pleiotropy or heterogeneity was detected in the analyses.DiscussionOur study suggested that while psychiatric disorders and traits might play various roles in the risk of developing PD, PD might also be involved in the risk of developing psychiatric disorders. |
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| spelling | doaj.art-3b98a6cf254d41a6a8d41274400272692023-03-14T04:53:12ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-03-011510.3389/fnagi.2023.11206151120615Bidirectional Mendelian randomization study of psychiatric disorders and Parkinson’s diseaseQi Wu0Qi Wu1Shulin Liu2Xiurong Huang3Jiabin Liu4Yige Wang5Yaqing Xiang6Xuxiong Tang7Xuxiong Tang8Qian Xu9Qian Xu10Qian Xu11Qian Xu12Qian Xu13Qian Xu14Xinxiang Yan15Xinxiang Yan16Xinxiang Yan17Xinxiang Yan18Xinxiang Yan19Beisha Tang20Beisha Tang21Beisha Tang22Beisha Tang23Beisha Tang24Jifeng Guo25Jifeng Guo26Jifeng Guo27Jifeng Guo28Jifeng Guo29Jifeng Guo30Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, ChinaHunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, ChinaCenter for Medical Genetics and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, ChinaEngineering Research Center of Hunan Province in Cognitive Impairment Disorders, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, ChinaHunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, ChinaEngineering Research Center of Hunan Province in Cognitive Impairment Disorders, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, ChinaHunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, ChinaEngineering Research Center of Hunan Province in Cognitive Impairment Disorders, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, ChinaHunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, ChinaCenter for Medical Genetics and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, ChinaEngineering Research Center of Hunan Province in Cognitive Impairment Disorders, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaIntroductionAlthough the relationship between psychiatric disorders and Parkinson’s disease (PD) has attracted continuous research attention, the causal linkage between them has not reached a definite conclusion.MethodsTo identify the causal relationship between psychiatric disorders and PD, we used public summary-level data from the most recent and largest genome-wide association studies (GWASs) on psychiatric disorders and PD to conduct a bidirectional two-sample Mendelian randomization (MR). We applied stringent control steps in instrumental variable selection using the Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) method to rule out pleiotropy. The inverse-variance weighted (IVW) method was used to identify the causal relationship between psychiatric disorders and PD. Multiple MR analysis methods, including MR-Egger, weighted-median, and leave-one-out analyses, were used for sensitivity analysis, followed by heterogeneity tests. Further validation and reverse MR analyses were conducted to strengthen the results of the forward MR analysis.ResultsThe lack of sufficient estimation results could suggest a causal relationship between psychiatric disorders and PD in the forward MR analysis. However, the subsequent reverse MR analysis detected a causal relationship between PD and bipolar disorder (IVW: odds ratios [OR] =1.053, 95% confidence interval [CI] =1.02–1.09, p = 0.001). Further analysis demonstrated a causal relationship between genetically predicted PD and the risk of bipolar disorder subtype. No pleiotropy or heterogeneity was detected in the analyses.DiscussionOur study suggested that while psychiatric disorders and traits might play various roles in the risk of developing PD, PD might also be involved in the risk of developing psychiatric disorders.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1120615/fullParkinson’s diseasepsychiatric disordersMendelian randomizationgenome-wide association studiescausal relationship |
| spellingShingle | Qi Wu Qi Wu Shulin Liu Xiurong Huang Jiabin Liu Yige Wang Yaqing Xiang Xuxiong Tang Xuxiong Tang Qian Xu Qian Xu Qian Xu Qian Xu Qian Xu Qian Xu Xinxiang Yan Xinxiang Yan Xinxiang Yan Xinxiang Yan Xinxiang Yan Beisha Tang Beisha Tang Beisha Tang Beisha Tang Beisha Tang Jifeng Guo Jifeng Guo Jifeng Guo Jifeng Guo Jifeng Guo Jifeng Guo Bidirectional Mendelian randomization study of psychiatric disorders and Parkinson’s disease Frontiers in Aging Neuroscience Parkinson’s disease psychiatric disorders Mendelian randomization genome-wide association studies causal relationship |
| title | Bidirectional Mendelian randomization study of psychiatric disorders and Parkinson’s disease |
| title_full | Bidirectional Mendelian randomization study of psychiatric disorders and Parkinson’s disease |
| title_fullStr | Bidirectional Mendelian randomization study of psychiatric disorders and Parkinson’s disease |
| title_full_unstemmed | Bidirectional Mendelian randomization study of psychiatric disorders and Parkinson’s disease |
| title_short | Bidirectional Mendelian randomization study of psychiatric disorders and Parkinson’s disease |
| title_sort | bidirectional mendelian randomization study of psychiatric disorders and parkinson s disease |
| topic | Parkinson’s disease psychiatric disorders Mendelian randomization genome-wide association studies causal relationship |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1120615/full |
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