The Role of Natural Products and Their Multitargeted Approach to Treat Solid Cancer
Natural products play a critical role in the discovery and development of numerous drugs for the treatment of various types of cancer. These phytochemicals have demonstrated anti-carcinogenic properties by interfering with the initiation, development, and progression of cancer through altering vario...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/14/2209 |
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| author | Naoshad Muhammad Darksha Usmani Mohammad Tarique Huma Naz Mohammad Ashraf Ramesh Raliya Shams Tabrez Torki A. Zughaibi Ahdab Alsaieedi Israa J. Hakeem Mohd Suhail |
| author_facet | Naoshad Muhammad Darksha Usmani Mohammad Tarique Huma Naz Mohammad Ashraf Ramesh Raliya Shams Tabrez Torki A. Zughaibi Ahdab Alsaieedi Israa J. Hakeem Mohd Suhail |
| author_sort | Naoshad Muhammad |
| collection | DOAJ |
| description | Natural products play a critical role in the discovery and development of numerous drugs for the treatment of various types of cancer. These phytochemicals have demonstrated anti-carcinogenic properties by interfering with the initiation, development, and progression of cancer through altering various mechanisms such as cellular proliferation, differentiation, apoptosis, angiogenesis, and metastasis. Treating multifactorial diseases, such as cancer with agents targeting a single target, might lead to limited success and, in many cases, unsatisfactory outcomes. Various epidemiological studies have shown that the steady consumption of fruits and vegetables is intensely associated with a reduced risk of cancer. Since ancient period, plants, herbs, and other natural products have been used as healing agents. Likewise, most of the medicinal ingredients accessible today are originated from the natural resources. Regardless of achievements, developing bioactive compounds and drugs from natural products has remained challenging, in part because of the problem associated with large-scale sequestration and mechanistic understanding. With significant progress in the landscape of cancer therapy and the rising use of cutting-edge technologies, we may have come to a crossroads to review approaches to identify the potential natural products and investigate their therapeutic efficacy. In the present review, we summarize the recent developments in natural products-based cancer research and its application in generating novel systemic strategies with a focus on underlying molecular mechanisms in solid cancer. |
| first_indexed | 2024-03-09T12:05:29Z |
| format | Article |
| id | doaj.art-3b99b8fd8249463688e1ade9d0be13a1 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T12:05:29Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-3b99b8fd8249463688e1ade9d0be13a12023-11-30T22:58:41ZengMDPI AGCells2073-44092022-07-011114220910.3390/cells11142209The Role of Natural Products and Their Multitargeted Approach to Treat Solid CancerNaoshad Muhammad0Darksha Usmani1Mohammad Tarique2Huma Naz3Mohammad Ashraf4Ramesh Raliya5Shams Tabrez6Torki A. Zughaibi7Ahdab Alsaieedi8Israa J. Hakeem9Mohd Suhail10Department of Radiation Oncology, School of Medicine, Washington University, Saint Louis, MO 63130, USAG-Bioscience, 9800 Page Ave., St. Louis, MO 63132, USADepartment of Child Health, University of Missouri, Columbia, MO 65211, USADepartment of Internal Medicine, University of Missouri, Columbia, MO 65211, USADepartment of Chemistry, Bundelkhand University Jhansi, Jhansi 284128, Uttar Pradesh, IndiaIFFCO Nano Biotechnology Research Center, Kalol 382423, Gujarat, IndiaKing Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi ArabiaKing Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Biochemistry, College of Science, University of Jeddah, Jeddah 21959, Saudi ArabiaKing Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi ArabiaNatural products play a critical role in the discovery and development of numerous drugs for the treatment of various types of cancer. These phytochemicals have demonstrated anti-carcinogenic properties by interfering with the initiation, development, and progression of cancer through altering various mechanisms such as cellular proliferation, differentiation, apoptosis, angiogenesis, and metastasis. Treating multifactorial diseases, such as cancer with agents targeting a single target, might lead to limited success and, in many cases, unsatisfactory outcomes. Various epidemiological studies have shown that the steady consumption of fruits and vegetables is intensely associated with a reduced risk of cancer. Since ancient period, plants, herbs, and other natural products have been used as healing agents. Likewise, most of the medicinal ingredients accessible today are originated from the natural resources. Regardless of achievements, developing bioactive compounds and drugs from natural products has remained challenging, in part because of the problem associated with large-scale sequestration and mechanistic understanding. With significant progress in the landscape of cancer therapy and the rising use of cutting-edge technologies, we may have come to a crossroads to review approaches to identify the potential natural products and investigate their therapeutic efficacy. In the present review, we summarize the recent developments in natural products-based cancer research and its application in generating novel systemic strategies with a focus on underlying molecular mechanisms in solid cancer.https://www.mdpi.com/2073-4409/11/14/2209medicinal plantsnatural productsphytochemicals and solid cancer |
| spellingShingle | Naoshad Muhammad Darksha Usmani Mohammad Tarique Huma Naz Mohammad Ashraf Ramesh Raliya Shams Tabrez Torki A. Zughaibi Ahdab Alsaieedi Israa J. Hakeem Mohd Suhail The Role of Natural Products and Their Multitargeted Approach to Treat Solid Cancer Cells medicinal plants natural products phytochemicals and solid cancer |
| title | The Role of Natural Products and Their Multitargeted Approach to Treat Solid Cancer |
| title_full | The Role of Natural Products and Their Multitargeted Approach to Treat Solid Cancer |
| title_fullStr | The Role of Natural Products and Their Multitargeted Approach to Treat Solid Cancer |
| title_full_unstemmed | The Role of Natural Products and Their Multitargeted Approach to Treat Solid Cancer |
| title_short | The Role of Natural Products and Their Multitargeted Approach to Treat Solid Cancer |
| title_sort | role of natural products and their multitargeted approach to treat solid cancer |
| topic | medicinal plants natural products phytochemicals and solid cancer |
| url | https://www.mdpi.com/2073-4409/11/14/2209 |
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