Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders

Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders

Alternative polyadenylation (APA) contributes to the post-transcriptional regulation of most human genes, yet the effects of APA are largely overlooked by conventional transcriptome-wide association studies (TWAS). Here, the authors conduct an APA-TWAS for 11 brain disorders, identifying hundreds of...

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Bibliographic Details
Main Authors: Ya Cui, Frederick J. Arnold, Fanglue Peng, Dan Wang, Jason Sheng Li, Sebastian Michels, Eric J. Wagner, Albert R. La Spada, Wei Li
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36311-8

Internet

https://doi.org/10.1038/s41467-023-36311-8

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