The Link between Obesity and Inflammatory Markers in the Development of Type 2 Diabetes in Men of Black African and White European Ethnicity
In this study, we aimed to assess ethnic differences in visceral (VAT), deep subcutaneous (dSAT), and superficial subcutaneous (sSAT) adipose tissue and their relationships with inflammatory markers between white European (WE) and black West African (BWA) men with normal glucose tolerance (NGT) and...
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MDPI AG
2020-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/12/3796 |
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| author | Olah Hakim Oluwatoyosi Bello Meera Ladwa Janet L. Peacock A. Margot Umpleby Geoffrey Charles-Edwards Stephanie A. Amiel Louise M. Goff |
| author_facet | Olah Hakim Oluwatoyosi Bello Meera Ladwa Janet L. Peacock A. Margot Umpleby Geoffrey Charles-Edwards Stephanie A. Amiel Louise M. Goff |
| author_sort | Olah Hakim |
| collection | DOAJ |
| description | In this study, we aimed to assess ethnic differences in visceral (VAT), deep subcutaneous (dSAT), and superficial subcutaneous (sSAT) adipose tissue and their relationships with inflammatory markers between white European (WE) and black West African (BWA) men with normal glucose tolerance (NGT) and type 2 diabetes (T2D). Forty-two WE (23 NGT/19 T2D) and 43 BWA (23 NGT/20 T2D) men underwent assessment of plasma inflammatory markers using immunoassays alongside Dixon magnetic resonance imaging to quantify L4-5 VAT, dSAT and sSAT. Despite no ethnic differences in sSAT and dSAT, BWA men exhibited lower VAT (<i>p</i> = 0.002) and dSAT:sSAT (<i>p</i> = 0.047) than WE men. Adiponectin was inversely associated with sSAT in WE (<i>p</i> = 0.041) but positively associated in BWA (<i>p</i> = 0.031) men with T2D. Interleukin-6 (IL-6) was associated with VAT in WE but not in BWA men with NGT (WE: <i>p</i> = 0.009, BWA: <i>p</i> = 0.137) and T2D (WE: <i>p</i> = 0.070, BWA: <i>p</i> = 0.175). IL-6 was associated with dSAT in only WE men with NGT (WE: <i>p</i> = 0.030, BWA: <i>p</i> = 0.833). The only significant ethnicity interaction present was for the relationship between adiponectin and sSAT (<i>P</i><sub>interaction</sub> = 0.003). The favourable adipose tissue distribution and the weaker relationships between adiposity and inflammation in BWA men suggest that adipose tissue inflammation may play a lesser role in T2D in BWA than WE men. |
| first_indexed | 2024-03-10T14:09:35Z |
| format | Article |
| id | doaj.art-3b9d37c2d00c4183813174aecfd43a16 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T14:09:35Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
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| series | Nutrients |
| spelling | doaj.art-3b9d37c2d00c4183813174aecfd43a162023-11-21T00:18:16ZengMDPI AGNutrients2072-66432020-12-011212379610.3390/nu12123796The Link between Obesity and Inflammatory Markers in the Development of Type 2 Diabetes in Men of Black African and White European EthnicityOlah Hakim0Oluwatoyosi Bello1Meera Ladwa2Janet L. Peacock3A. Margot Umpleby4Geoffrey Charles-Edwards5Stephanie A. Amiel6Louise M. Goff7Diabetes Research Group, Departments of Diabetes & Nutritional Sciences, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King’s College London, Waterloo Campus, Franklin-Wilkins Building, Room 3.87, London SE1 9NH, UKDiabetes Research Group, Departments of Diabetes & Nutritional Sciences, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King’s College London, Waterloo Campus, Franklin-Wilkins Building, Room 3.87, London SE1 9NH, UKDiabetes Research Group, Departments of Diabetes & Nutritional Sciences, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King’s College London, Waterloo Campus, Franklin-Wilkins Building, Room 3.87, London SE1 9NH, UKDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, NH 03755-1404, USAFaculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UKMedical Physics, Guy’s & St Thomas’ NHS Foundation Trust, London SE1 7EH, UKDiabetes Research Group, Departments of Diabetes & Nutritional Sciences, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King’s College London, Waterloo Campus, Franklin-Wilkins Building, Room 3.87, London SE1 9NH, UKDiabetes Research Group, Departments of Diabetes & Nutritional Sciences, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King’s College London, Waterloo Campus, Franklin-Wilkins Building, Room 3.87, London SE1 9NH, UKIn this study, we aimed to assess ethnic differences in visceral (VAT), deep subcutaneous (dSAT), and superficial subcutaneous (sSAT) adipose tissue and their relationships with inflammatory markers between white European (WE) and black West African (BWA) men with normal glucose tolerance (NGT) and type 2 diabetes (T2D). Forty-two WE (23 NGT/19 T2D) and 43 BWA (23 NGT/20 T2D) men underwent assessment of plasma inflammatory markers using immunoassays alongside Dixon magnetic resonance imaging to quantify L4-5 VAT, dSAT and sSAT. Despite no ethnic differences in sSAT and dSAT, BWA men exhibited lower VAT (<i>p</i> = 0.002) and dSAT:sSAT (<i>p</i> = 0.047) than WE men. Adiponectin was inversely associated with sSAT in WE (<i>p</i> = 0.041) but positively associated in BWA (<i>p</i> = 0.031) men with T2D. Interleukin-6 (IL-6) was associated with VAT in WE but not in BWA men with NGT (WE: <i>p</i> = 0.009, BWA: <i>p</i> = 0.137) and T2D (WE: <i>p</i> = 0.070, BWA: <i>p</i> = 0.175). IL-6 was associated with dSAT in only WE men with NGT (WE: <i>p</i> = 0.030, BWA: <i>p</i> = 0.833). The only significant ethnicity interaction present was for the relationship between adiponectin and sSAT (<i>P</i><sub>interaction</sub> = 0.003). The favourable adipose tissue distribution and the weaker relationships between adiposity and inflammation in BWA men suggest that adipose tissue inflammation may play a lesser role in T2D in BWA than WE men.https://www.mdpi.com/2072-6643/12/12/3796visceral adipose tissuedeep subcutaneous adipose tissuesuperficial subcutaneous adipose tissueinflammationethnicityAfrican |
| spellingShingle | Olah Hakim Oluwatoyosi Bello Meera Ladwa Janet L. Peacock A. Margot Umpleby Geoffrey Charles-Edwards Stephanie A. Amiel Louise M. Goff The Link between Obesity and Inflammatory Markers in the Development of Type 2 Diabetes in Men of Black African and White European Ethnicity Nutrients visceral adipose tissue deep subcutaneous adipose tissue superficial subcutaneous adipose tissue inflammation ethnicity African |
| title | The Link between Obesity and Inflammatory Markers in the Development of Type 2 Diabetes in Men of Black African and White European Ethnicity |
| title_full | The Link between Obesity and Inflammatory Markers in the Development of Type 2 Diabetes in Men of Black African and White European Ethnicity |
| title_fullStr | The Link between Obesity and Inflammatory Markers in the Development of Type 2 Diabetes in Men of Black African and White European Ethnicity |
| title_full_unstemmed | The Link between Obesity and Inflammatory Markers in the Development of Type 2 Diabetes in Men of Black African and White European Ethnicity |
| title_short | The Link between Obesity and Inflammatory Markers in the Development of Type 2 Diabetes in Men of Black African and White European Ethnicity |
| title_sort | link between obesity and inflammatory markers in the development of type 2 diabetes in men of black african and white european ethnicity |
| topic | visceral adipose tissue deep subcutaneous adipose tissue superficial subcutaneous adipose tissue inflammation ethnicity African |
| url | https://www.mdpi.com/2072-6643/12/12/3796 |
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