The effect of percutaneous coronary revascularization on plasma N-terminal pro-B-type natriuretic peptide levels in stable coronary artery disease
Background: This study was conducted to assess the effect of percutaneous coronary revascularization (PCR) on plasma NT-proBNP concentration in patients with chronic stable angina (CSA). Methods: This prospective open label interventional study included 22 patients with moderate to severe CSA, norma...
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| Format: | Article |
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Elsevier
2018-03-01
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| Series: | Indian Heart Journal |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0019483216309750 |
| _version_ | 1819173593717669888 |
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| author | Amit Gupta Jahangir Rashid Beig Nisar A. Tramboo Dil Afroze Imran Hafeez Hilal A. Rather |
| author_facet | Amit Gupta Jahangir Rashid Beig Nisar A. Tramboo Dil Afroze Imran Hafeez Hilal A. Rather |
| author_sort | Amit Gupta |
| collection | DOAJ |
| description | Background: This study was conducted to assess the effect of percutaneous coronary revascularization (PCR) on plasma NT-proBNP concentration in patients with chronic stable angina (CSA). Methods: This prospective open label interventional study included 22 patients with moderate to severe CSA, normal left ventricular (LV) systolic functions and critical (>90%) proximal stenosis in one of the three major epicardial coronary arteries. After stabilization of medications for 8 weeks, resting supine plasma NT-proBNP levels were measured and patients underwent PCR of the involved vessels. Eight weeks later, with medications unaltered; plasma NT-proBNP levels were repeated and compared with the baseline levels. LV systolic and diastolic functions were assessed before and after PCR. Results: The mean age of the patients was 61.27 ± 8.87 years. Out of 22 patients, 20 were male and 2 were female. PCR was performed on left anterior descending coronary artery (LAD) in 12 patients and in a non-LAD vessel in 10 patients. After 8 weeks of successful PCR, there was a significant overall reduction in mean plasma NT-proBNP levels (from 244.36 ± 218.99 to 168.68 ± 161.61 pg/mL, p = 0.016). The patients who underwent PCR of LAD demonstrated significantly reduced NT-pro-BNP levels after PCR (p = 0.009). In the non-LAD group, NT-proBNP levels also decreased, albeit insignificantly (p = 0.432). Reduction in NT-proBNP was independent of change in LV systolic functions. Conclusion: Successful PCR, by relieving myocardial ischemia, significantly reduced plasma NT-proBNP levels in majority of the patients with chronic stable angina secondary to critical epicardial coronary artery stenosis. Keywords: Coronary artery disease, Chronic stable angina, NT-ProBNP, Percutaneous coronary revascularization |
| first_indexed | 2024-12-22T20:25:33Z |
| format | Article |
| id | doaj.art-3b9e3d36364e4166a0e3be46b64fb057 |
| institution | Directory Open Access Journal |
| issn | 0019-4832 |
| language | English |
| last_indexed | 2024-12-22T20:25:33Z |
| publishDate | 2018-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Indian Heart Journal |
| spelling | doaj.art-3b9e3d36364e4166a0e3be46b64fb0572022-12-21T18:13:44ZengElsevierIndian Heart Journal0019-48322018-03-01702282288The effect of percutaneous coronary revascularization on plasma N-terminal pro-B-type natriuretic peptide levels in stable coronary artery diseaseAmit Gupta0Jahangir Rashid Beig1Nisar A. Tramboo2Dil Afroze3Imran Hafeez4Hilal A. Rather5Department of Cardiology, SKIMS, Srinagar, IndiaDepartment of Cardiology, SKIMS, Srinagar, India; *Corresponding author at: Department of Cardiology, SKIMS, Soura, Srinagar, Jammu & Kashmir, 190011, India.Department of Cardiology, SKIMS, Srinagar, IndiaDepartment of Immunology, SKIMS, Srinagar, IndiaDepartment of Cardiology, SKIMS, Srinagar, IndiaDepartment of Cardiology, SKIMS, Srinagar, IndiaBackground: This study was conducted to assess the effect of percutaneous coronary revascularization (PCR) on plasma NT-proBNP concentration in patients with chronic stable angina (CSA). Methods: This prospective open label interventional study included 22 patients with moderate to severe CSA, normal left ventricular (LV) systolic functions and critical (>90%) proximal stenosis in one of the three major epicardial coronary arteries. After stabilization of medications for 8 weeks, resting supine plasma NT-proBNP levels were measured and patients underwent PCR of the involved vessels. Eight weeks later, with medications unaltered; plasma NT-proBNP levels were repeated and compared with the baseline levels. LV systolic and diastolic functions were assessed before and after PCR. Results: The mean age of the patients was 61.27 ± 8.87 years. Out of 22 patients, 20 were male and 2 were female. PCR was performed on left anterior descending coronary artery (LAD) in 12 patients and in a non-LAD vessel in 10 patients. After 8 weeks of successful PCR, there was a significant overall reduction in mean plasma NT-proBNP levels (from 244.36 ± 218.99 to 168.68 ± 161.61 pg/mL, p = 0.016). The patients who underwent PCR of LAD demonstrated significantly reduced NT-pro-BNP levels after PCR (p = 0.009). In the non-LAD group, NT-proBNP levels also decreased, albeit insignificantly (p = 0.432). Reduction in NT-proBNP was independent of change in LV systolic functions. Conclusion: Successful PCR, by relieving myocardial ischemia, significantly reduced plasma NT-proBNP levels in majority of the patients with chronic stable angina secondary to critical epicardial coronary artery stenosis. Keywords: Coronary artery disease, Chronic stable angina, NT-ProBNP, Percutaneous coronary revascularizationhttp://www.sciencedirect.com/science/article/pii/S0019483216309750 |
| spellingShingle | Amit Gupta Jahangir Rashid Beig Nisar A. Tramboo Dil Afroze Imran Hafeez Hilal A. Rather The effect of percutaneous coronary revascularization on plasma N-terminal pro-B-type natriuretic peptide levels in stable coronary artery disease Indian Heart Journal |
| title | The effect of percutaneous coronary revascularization on plasma N-terminal pro-B-type natriuretic peptide levels in stable coronary artery disease |
| title_full | The effect of percutaneous coronary revascularization on plasma N-terminal pro-B-type natriuretic peptide levels in stable coronary artery disease |
| title_fullStr | The effect of percutaneous coronary revascularization on plasma N-terminal pro-B-type natriuretic peptide levels in stable coronary artery disease |
| title_full_unstemmed | The effect of percutaneous coronary revascularization on plasma N-terminal pro-B-type natriuretic peptide levels in stable coronary artery disease |
| title_short | The effect of percutaneous coronary revascularization on plasma N-terminal pro-B-type natriuretic peptide levels in stable coronary artery disease |
| title_sort | effect of percutaneous coronary revascularization on plasma n terminal pro b type natriuretic peptide levels in stable coronary artery disease |
| url | http://www.sciencedirect.com/science/article/pii/S0019483216309750 |
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