Preoperative Serum Gamma-Glutamyltransferase as a Prognostic Biomarker in Patients Undergoing Radical Cystectomy for Bladder Cancer
BackgroundSerum gamma-glutamyltransferase (GGT) has been reported to be correlated with survival in a variety of malignancies. However, its effect on patients with bladder cancer (BC) treated by radical cystectomy has never been evaluated.Patients and MethodsWe retrospectively evaluated 263 patients...
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.648904/full |
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| author | Shiqiang Su Lizhe Liu Chao Sun Yanhua Nie Hong Guo Yang Hu Shunli Guo Shujian Pang |
| author_facet | Shiqiang Su Lizhe Liu Chao Sun Yanhua Nie Hong Guo Yang Hu Shunli Guo Shujian Pang |
| author_sort | Shiqiang Su |
| collection | DOAJ |
| description | BackgroundSerum gamma-glutamyltransferase (GGT) has been reported to be correlated with survival in a variety of malignancies. However, its effect on patients with bladder cancer (BC) treated by radical cystectomy has never been evaluated.Patients and MethodsWe retrospectively evaluated 263 patients who underwent radical surgery in our center. Baseline features, hematologic variables, and follow-up data were obtained. The endpoints included overall survival (OS), cancer-specific survival (CSS), and disease-free survival (DFS). The relationship between GGT and survival were evaluated.ResultsThe median follow-up period for all patients was 34.7 (22.9-45.9) months. At the last follow-up, 67 patients died, 51 patients died of cancer, 92 patients experienced disease recurrence. Patients with an elevated serum GGT had a higher rate of pT3-T4 tumors. Patients with a higher preoperative serum GGT had a lower rate of OS, CSS and DFS (P < 0.001 for all). Multivariate analysis identified that preoperative serum GGT was independent predictor of OS (HR: 3.027, 95% CI: 1.716-5.338; P < 0.001), CSS (HR: 2.115, 95% CI: 1.093-4.090; P = 0.026), DFS (HR: 2.584, 95% CI: 1.569-4.255; P < 0.001). Age, diabetes history, pathologic T stage, and lymph node status also were independent predictors of prognosis for BC patients.ConclusionsOur results indicated that preoperative serum GGT was an independent prognosis predictor for survival of BC patients after radical cystectomy, and can be included in the prognostic models. |
| first_indexed | 2024-12-16T12:35:12Z |
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| language | English |
| last_indexed | 2024-12-16T12:35:12Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-3ba1d96b86664626a8af693a9301a4722022-12-21T22:31:36ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-05-011110.3389/fonc.2021.648904648904Preoperative Serum Gamma-Glutamyltransferase as a Prognostic Biomarker in Patients Undergoing Radical Cystectomy for Bladder CancerShiqiang Su0Lizhe Liu1Chao Sun2Yanhua Nie3Hong Guo4Yang Hu5Shunli Guo6Shujian Pang7Department of Urology, Shijiazhuang People’s Hospital, Shijiazhuang, ChinaInstitute of Medicine and Health, Hebei Medical University, Shijiazhuang, ChinaDepartment of Urology, Shijiazhuang People’s Hospital, Shijiazhuang, ChinaDepartment of Urology, Shijiazhuang People’s Hospital, Shijiazhuang, ChinaDepartment of Urology, Shijiazhuang People’s Hospital, Shijiazhuang, ChinaDepartment of Urology, Shijiazhuang People’s Hospital, Shijiazhuang, ChinaDepartment of Urology, Shijiazhuang People’s Hospital, Shijiazhuang, ChinaDepartment of Urology, Shijiazhuang People’s Hospital, Shijiazhuang, ChinaBackgroundSerum gamma-glutamyltransferase (GGT) has been reported to be correlated with survival in a variety of malignancies. However, its effect on patients with bladder cancer (BC) treated by radical cystectomy has never been evaluated.Patients and MethodsWe retrospectively evaluated 263 patients who underwent radical surgery in our center. Baseline features, hematologic variables, and follow-up data were obtained. The endpoints included overall survival (OS), cancer-specific survival (CSS), and disease-free survival (DFS). The relationship between GGT and survival were evaluated.ResultsThe median follow-up period for all patients was 34.7 (22.9-45.9) months. At the last follow-up, 67 patients died, 51 patients died of cancer, 92 patients experienced disease recurrence. Patients with an elevated serum GGT had a higher rate of pT3-T4 tumors. Patients with a higher preoperative serum GGT had a lower rate of OS, CSS and DFS (P < 0.001 for all). Multivariate analysis identified that preoperative serum GGT was independent predictor of OS (HR: 3.027, 95% CI: 1.716-5.338; P < 0.001), CSS (HR: 2.115, 95% CI: 1.093-4.090; P = 0.026), DFS (HR: 2.584, 95% CI: 1.569-4.255; P < 0.001). Age, diabetes history, pathologic T stage, and lymph node status also were independent predictors of prognosis for BC patients.ConclusionsOur results indicated that preoperative serum GGT was an independent prognosis predictor for survival of BC patients after radical cystectomy, and can be included in the prognostic models.https://www.frontiersin.org/articles/10.3389/fonc.2021.648904/fullbladder cancerradical cystectomygamma-glutamyltransferaseprognosisbiomarkers |
| spellingShingle | Shiqiang Su Lizhe Liu Chao Sun Yanhua Nie Hong Guo Yang Hu Shunli Guo Shujian Pang Preoperative Serum Gamma-Glutamyltransferase as a Prognostic Biomarker in Patients Undergoing Radical Cystectomy for Bladder Cancer Frontiers in Oncology bladder cancer radical cystectomy gamma-glutamyltransferase prognosis biomarkers |
| title | Preoperative Serum Gamma-Glutamyltransferase as a Prognostic Biomarker in Patients Undergoing Radical Cystectomy for Bladder Cancer |
| title_full | Preoperative Serum Gamma-Glutamyltransferase as a Prognostic Biomarker in Patients Undergoing Radical Cystectomy for Bladder Cancer |
| title_fullStr | Preoperative Serum Gamma-Glutamyltransferase as a Prognostic Biomarker in Patients Undergoing Radical Cystectomy for Bladder Cancer |
| title_full_unstemmed | Preoperative Serum Gamma-Glutamyltransferase as a Prognostic Biomarker in Patients Undergoing Radical Cystectomy for Bladder Cancer |
| title_short | Preoperative Serum Gamma-Glutamyltransferase as a Prognostic Biomarker in Patients Undergoing Radical Cystectomy for Bladder Cancer |
| title_sort | preoperative serum gamma glutamyltransferase as a prognostic biomarker in patients undergoing radical cystectomy for bladder cancer |
| topic | bladder cancer radical cystectomy gamma-glutamyltransferase prognosis biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.648904/full |
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