Health status and risk profiles for brain aging of rural‐dwelling older adults: Data from the interdisciplinary baseline assessments in MIND‐China
Abstract Introduction Multidomain intervention approaches have emerged as a potential strategy to reduce dementia risk. We sought to describe the baseline assessment approaches, health conditions, and risk profiles for brain aging of participants in the randomized controlled Multimodal INterventions...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/trc2.12254 |
| _version_ | 1797949050049265664 |
|---|---|
| author | Yongxiang Wang Xiaolei Han Xianda Zhang Zhonglin Zhang Lin Cong Shi Tang Tingting Hou Cuicui Liu Xiaojuan Han Qinghua Zhang Jianli Feng Ling Yin Lin Song Yi Dong Rui Liu Yuanjing Li Tiia Ngandu Miia Kivipelto Heather Snyder Maria Carrillo Jonas Persson Laura Fratiglioni Lenore J Launer Jianping Jia Yifeng Du Chengxuan Qiu |
| author_facet | Yongxiang Wang Xiaolei Han Xianda Zhang Zhonglin Zhang Lin Cong Shi Tang Tingting Hou Cuicui Liu Xiaojuan Han Qinghua Zhang Jianli Feng Ling Yin Lin Song Yi Dong Rui Liu Yuanjing Li Tiia Ngandu Miia Kivipelto Heather Snyder Maria Carrillo Jonas Persson Laura Fratiglioni Lenore J Launer Jianping Jia Yifeng Du Chengxuan Qiu |
| author_sort | Yongxiang Wang |
| collection | DOAJ |
| description | Abstract Introduction Multidomain intervention approaches have emerged as a potential strategy to reduce dementia risk. We sought to describe the baseline assessment approaches, health conditions, and risk profiles for brain aging of participants in the randomized controlled Multimodal INterventions to delay Dementia and disability in rural China (MIND‐China). Methods MIND‐China engaged residents who were ≥60 years of age and living in rural communities in the western Shandong province. In March to September 2018, all participants underwent the core module assessments via face‐to‐face interviews, clinical examinations, neuropsychological testings, and laboratory tests. Specific modules of examination were performed for sub‐samples, including brain magnetic resonance imaging scans, genetic and blood biochemical markers, actigraphy testing, cardiopulmonary coupling analysis for sleep quality and disturbances, audiometric testing, and optical coherence tomography examination. We performed descriptive analysis. Results In total, 5765 participants (74.9% of all eligible residents) undertook the baseline assessments. The mean age was 70.9 years (standard deviation, 5.9), 57.2% were women, 40.6% were illiterate, and 88.3% were farmers. The overall prevalence of common chronic diseases was 67.2% for hypertension, 23.4% for dyslipidemia, 23.5% for heart disease, 14.4% for diabetes mellitus, and 5.4% for dementia. The prevalence rates of hypertension, diabetes mellitus, dyslipidemia, obesity, heart disease, depressive symptoms, and dementia were higher in women than in men (P < .05). Overall, 87.1% of the participants had at least two of the 15 chronic diseases (89.3% in women vs 84.2% in men, P < .001). Participants examined for the specific modules were younger, more likely to be women, and more educated than those not examined. Discussion Comprehensive baseline assessments of participants in MIND‐China provide extremely valuable data sources for interdisciplinary research into the complex relationships of aging, health, brain aging, and functional consequences among older adults living in the rural communities. Highlights MIND‐China is a multimodal intervention study among rural residents ≥60 years of age. At baseline, 5765 participants undertook the interdisciplinary assessments. The baseline assessments consisted of core module and specific modules. Specific modules included brain magnetic resonance imaging (MRI), blood biomarkers, ActiGraph, cardiopulmonary coupling (CPC), pure‐tone audiometry (PTA), and optical coherence tomography (OCT). |
| first_indexed | 2024-04-10T21:53:12Z |
| format | Article |
| id | doaj.art-3ba2c57b07be4ebca42c47e3ca5c4930 |
| institution | Directory Open Access Journal |
| issn | 2352-8737 |
| language | English |
| last_indexed | 2024-04-10T21:53:12Z |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj.art-3ba2c57b07be4ebca42c47e3ca5c49302023-01-18T11:41:03ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372022-01-0181n/an/a10.1002/trc2.12254Health status and risk profiles for brain aging of rural‐dwelling older adults: Data from the interdisciplinary baseline assessments in MIND‐ChinaYongxiang Wang0Xiaolei Han1Xianda Zhang2Zhonglin Zhang3Lin Cong4Shi Tang5Tingting Hou6Cuicui Liu7Xiaojuan Han8Qinghua Zhang9Jianli Feng10Ling Yin11Lin Song12Yi Dong13Rui Liu14Yuanjing Li15Tiia Ngandu16Miia Kivipelto17Heather Snyder18Maria Carrillo19Jonas Persson20Laura Fratiglioni21Lenore J Launer22Jianping Jia23Yifeng Du24Chengxuan Qiu25Department of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University Jinan Shandong ChinaDepartment of Neurology Shandong Provincial Hospital Cheeloo College of Medicine Shandong University Jinan Shandong ChinaYanlou Town Hospital Yanggu Shandong ChinaYanlou Town Hospital Yanggu Shandong ChinaDepartment of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University Jinan Shandong ChinaDepartment of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University Jinan Shandong ChinaDepartment of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University Jinan Shandong ChinaDepartment of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University Jinan Shandong ChinaDepartment of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University Jinan Shandong ChinaDepartment of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University Jinan Shandong ChinaDepartment of Neurology Shandong Second Provincial General Hospital Shandong Provincial ENT Hospital Jinan Shandong ChinaDepartment of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University Jinan Shandong ChinaDepartment of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University Jinan Shandong ChinaDepartment of Neurology Shandong Provincial Hospital Cheeloo College of Medicine Shandong University Jinan Shandong ChinaDepartment of Neurology Shandong Provincial Hospital Cheeloo College of Medicine Shandong University Jinan Shandong ChinaDepartment of Neurology Shandong Provincial Hospital Cheeloo College of Medicine Shandong University Jinan Shandong ChinaDivision of Clinical Geriatrics and Center for Alzheimer Research Department of Neurobiology Care Sciences and Society (NVS) Karolinska Institutet Stockholm SwedenDivision of Clinical Geriatrics and Center for Alzheimer Research Department of Neurobiology Care Sciences and Society (NVS) Karolinska Institutet Stockholm SwedenAlzheimer's Association Chicago Illinois USAAlzheimer's Association Chicago Illinois USAAging Research Center Department of NVS Karolinska Institutet and Stockholm University Stockholm SwedenAging Research Center Department of NVS Karolinska Institutet and Stockholm University Stockholm SwedenIntramural Research Program Laboratory of Epidemiology and Population Sciences National Institute on Aging National Institutes of Health Baltimore Maryland USAInnovation Center for Neurological Disorders Department of Neurology Xuanwu Hospital Capital Medical University Beijing ChinaDepartment of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University Jinan Shandong ChinaDepartment of Neurology Shandong Provincial Hospital Cheeloo College of Medicine Shandong University Jinan Shandong ChinaAbstract Introduction Multidomain intervention approaches have emerged as a potential strategy to reduce dementia risk. We sought to describe the baseline assessment approaches, health conditions, and risk profiles for brain aging of participants in the randomized controlled Multimodal INterventions to delay Dementia and disability in rural China (MIND‐China). Methods MIND‐China engaged residents who were ≥60 years of age and living in rural communities in the western Shandong province. In March to September 2018, all participants underwent the core module assessments via face‐to‐face interviews, clinical examinations, neuropsychological testings, and laboratory tests. Specific modules of examination were performed for sub‐samples, including brain magnetic resonance imaging scans, genetic and blood biochemical markers, actigraphy testing, cardiopulmonary coupling analysis for sleep quality and disturbances, audiometric testing, and optical coherence tomography examination. We performed descriptive analysis. Results In total, 5765 participants (74.9% of all eligible residents) undertook the baseline assessments. The mean age was 70.9 years (standard deviation, 5.9), 57.2% were women, 40.6% were illiterate, and 88.3% were farmers. The overall prevalence of common chronic diseases was 67.2% for hypertension, 23.4% for dyslipidemia, 23.5% for heart disease, 14.4% for diabetes mellitus, and 5.4% for dementia. The prevalence rates of hypertension, diabetes mellitus, dyslipidemia, obesity, heart disease, depressive symptoms, and dementia were higher in women than in men (P < .05). Overall, 87.1% of the participants had at least two of the 15 chronic diseases (89.3% in women vs 84.2% in men, P < .001). Participants examined for the specific modules were younger, more likely to be women, and more educated than those not examined. Discussion Comprehensive baseline assessments of participants in MIND‐China provide extremely valuable data sources for interdisciplinary research into the complex relationships of aging, health, brain aging, and functional consequences among older adults living in the rural communities. Highlights MIND‐China is a multimodal intervention study among rural residents ≥60 years of age. At baseline, 5765 participants undertook the interdisciplinary assessments. The baseline assessments consisted of core module and specific modules. Specific modules included brain magnetic resonance imaging (MRI), blood biomarkers, ActiGraph, cardiopulmonary coupling (CPC), pure‐tone audiometry (PTA), and optical coherence tomography (OCT).https://doi.org/10.1002/trc2.12254dementiamultimodal interventionolder adultspopulation‐based studyrural area |
| spellingShingle | Yongxiang Wang Xiaolei Han Xianda Zhang Zhonglin Zhang Lin Cong Shi Tang Tingting Hou Cuicui Liu Xiaojuan Han Qinghua Zhang Jianli Feng Ling Yin Lin Song Yi Dong Rui Liu Yuanjing Li Tiia Ngandu Miia Kivipelto Heather Snyder Maria Carrillo Jonas Persson Laura Fratiglioni Lenore J Launer Jianping Jia Yifeng Du Chengxuan Qiu Health status and risk profiles for brain aging of rural‐dwelling older adults: Data from the interdisciplinary baseline assessments in MIND‐China Alzheimer’s & Dementia: Translational Research & Clinical Interventions dementia multimodal intervention older adults population‐based study rural area |
| title | Health status and risk profiles for brain aging of rural‐dwelling older adults: Data from the interdisciplinary baseline assessments in MIND‐China |
| title_full | Health status and risk profiles for brain aging of rural‐dwelling older adults: Data from the interdisciplinary baseline assessments in MIND‐China |
| title_fullStr | Health status and risk profiles for brain aging of rural‐dwelling older adults: Data from the interdisciplinary baseline assessments in MIND‐China |
| title_full_unstemmed | Health status and risk profiles for brain aging of rural‐dwelling older adults: Data from the interdisciplinary baseline assessments in MIND‐China |
| title_short | Health status and risk profiles for brain aging of rural‐dwelling older adults: Data from the interdisciplinary baseline assessments in MIND‐China |
| title_sort | health status and risk profiles for brain aging of rural dwelling older adults data from the interdisciplinary baseline assessments in mind china |
| topic | dementia multimodal intervention older adults population‐based study rural area |
| url | https://doi.org/10.1002/trc2.12254 |
| work_keys_str_mv | AT yongxiangwang healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT xiaoleihan healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT xiandazhang healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT zhonglinzhang healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT lincong healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT shitang healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT tingtinghou healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT cuicuiliu healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT xiaojuanhan healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT qinghuazhang healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT jianlifeng healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT lingyin healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT linsong healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT yidong healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT ruiliu healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT yuanjingli healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT tiiangandu healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT miiakivipelto healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT heathersnyder healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT mariacarrillo healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT jonaspersson healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT laurafratiglioni healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT lenorejlauner healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT jianpingjia healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT yifengdu healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina AT chengxuanqiu healthstatusandriskprofilesforbrainagingofruraldwellingolderadultsdatafromtheinterdisciplinarybaselineassessmentsinmindchina |