Outcome measures of the 6 minute walk test: relationships with physiologic and computed tomography findings in patients with sarcoidosis
<p>Abstract</p> <p>Background</p> <p>We assessed the relationship between physiologic parameters, computed tomography patterns, 6 minute walk distance (6MWD) and the distance-saturation product [DSP; defined as the product of the 6MWD and the lowest oxygen saturation du...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-08-01
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| Series: | BMC Pulmonary Medicine |
| Online Access: | http://www.biomedcentral.com/1471-2466/10/42 |
| _version_ | 1811330067733676032 |
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| author | Alanezi Mohammed O Idrees Majdy M Shaik Shaffi Alhamad Esam H Isnani Arthur C |
| author_facet | Alanezi Mohammed O Idrees Majdy M Shaik Shaffi Alhamad Esam H Isnani Arthur C |
| author_sort | Alanezi Mohammed O |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>We assessed the relationship between physiologic parameters, computed tomography patterns, 6 minute walk distance (6MWD) and the distance-saturation product [DSP; defined as the product of the 6MWD and the lowest oxygen saturation during the 6 minute walk test (6MWT)]. In addition, we investigated factors affecting 6MWD in patients with pulmonary sarcoidosis.</p> <p>Methods</p> <p>We performed a retrospective study of patient demographics, treatment, pulmonary function, 6MWT, echocardiography and computed tomography results.</p> <p>Results</p> <p>Fifty nine patients were included in this study. Their mean+standard deviation age was 47.5 years + 12.5 years, and 42 (71.2%) were female. Mean pulmonary function parameters for forced vital capacity (FVC), forced expiratory volume in 1 second (FEV<sub>1</sub>) and total lung capacity (TLC) results, as percentages of predicted values, were 77.6 ± 22.2, 77.1 ± 22.8 and 78.7 ± 16.1, respectively. Comparison of the DSP with distance walked revealed a significant correlation with factors underlying reduced 6MWD, including gender, pulmonary function indices, partial pressure of oxygen (PaO<sub>2</sub>), and Borg dyspnea score. Other factors were significantly associated with DSP but not distance; these included lung fibrosis (p = 0.02), pulmonary hypertension (p = 0.01) and systemic therapy (p = 0.04). Backward elimination stepwise multiple regression analysis revealed that gender, and FEV<sub>1 </sub>were independent predictors of 6MWD, but FEV<sub>1 </sub>was more strongly related when DSP applied [DSP, R<sup>2 </sup>= 0.53, p = 0.02; distance, R<sup>2 </sup>= 0.45, p < 0.0001].</p> <p>Conclusion</p> <p>Our findings reveal that, compared to 6MWD alone, the DSP is correlated with a greater number of factors associated with reduced 6MWT performance. Therefore, the DSP may be a useful indicator of functional status in patients with sarcoidosis. Additional large-scale studies are warranted to validate our findings.</p> |
| first_indexed | 2024-04-13T15:56:06Z |
| format | Article |
| id | doaj.art-3ba2e0440a0647b2bc60773640ec1cd7 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-04-13T15:56:06Z |
| publishDate | 2010-08-01 |
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| series | BMC Pulmonary Medicine |
| spelling | doaj.art-3ba2e0440a0647b2bc60773640ec1cd72022-12-22T02:40:42ZengBMCBMC Pulmonary Medicine1471-24662010-08-011014210.1186/1471-2466-10-42Outcome measures of the 6 minute walk test: relationships with physiologic and computed tomography findings in patients with sarcoidosisAlanezi Mohammed OIdrees Majdy MShaik ShaffiAlhamad Esam HIsnani Arthur C<p>Abstract</p> <p>Background</p> <p>We assessed the relationship between physiologic parameters, computed tomography patterns, 6 minute walk distance (6MWD) and the distance-saturation product [DSP; defined as the product of the 6MWD and the lowest oxygen saturation during the 6 minute walk test (6MWT)]. In addition, we investigated factors affecting 6MWD in patients with pulmonary sarcoidosis.</p> <p>Methods</p> <p>We performed a retrospective study of patient demographics, treatment, pulmonary function, 6MWT, echocardiography and computed tomography results.</p> <p>Results</p> <p>Fifty nine patients were included in this study. Their mean+standard deviation age was 47.5 years + 12.5 years, and 42 (71.2%) were female. Mean pulmonary function parameters for forced vital capacity (FVC), forced expiratory volume in 1 second (FEV<sub>1</sub>) and total lung capacity (TLC) results, as percentages of predicted values, were 77.6 ± 22.2, 77.1 ± 22.8 and 78.7 ± 16.1, respectively. Comparison of the DSP with distance walked revealed a significant correlation with factors underlying reduced 6MWD, including gender, pulmonary function indices, partial pressure of oxygen (PaO<sub>2</sub>), and Borg dyspnea score. Other factors were significantly associated with DSP but not distance; these included lung fibrosis (p = 0.02), pulmonary hypertension (p = 0.01) and systemic therapy (p = 0.04). Backward elimination stepwise multiple regression analysis revealed that gender, and FEV<sub>1 </sub>were independent predictors of 6MWD, but FEV<sub>1 </sub>was more strongly related when DSP applied [DSP, R<sup>2 </sup>= 0.53, p = 0.02; distance, R<sup>2 </sup>= 0.45, p < 0.0001].</p> <p>Conclusion</p> <p>Our findings reveal that, compared to 6MWD alone, the DSP is correlated with a greater number of factors associated with reduced 6MWT performance. Therefore, the DSP may be a useful indicator of functional status in patients with sarcoidosis. Additional large-scale studies are warranted to validate our findings.</p>http://www.biomedcentral.com/1471-2466/10/42 |
| spellingShingle | Alanezi Mohammed O Idrees Majdy M Shaik Shaffi Alhamad Esam H Isnani Arthur C Outcome measures of the 6 minute walk test: relationships with physiologic and computed tomography findings in patients with sarcoidosis BMC Pulmonary Medicine |
| title | Outcome measures of the 6 minute walk test: relationships with physiologic and computed tomography findings in patients with sarcoidosis |
| title_full | Outcome measures of the 6 minute walk test: relationships with physiologic and computed tomography findings in patients with sarcoidosis |
| title_fullStr | Outcome measures of the 6 minute walk test: relationships with physiologic and computed tomography findings in patients with sarcoidosis |
| title_full_unstemmed | Outcome measures of the 6 minute walk test: relationships with physiologic and computed tomography findings in patients with sarcoidosis |
| title_short | Outcome measures of the 6 minute walk test: relationships with physiologic and computed tomography findings in patients with sarcoidosis |
| title_sort | outcome measures of the 6 minute walk test relationships with physiologic and computed tomography findings in patients with sarcoidosis |
| url | http://www.biomedcentral.com/1471-2466/10/42 |
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