Epigenetic modifications in solid tumor metastasis in people of African ancestry
This review focuses on the critical role of epigenetic modifications in solid tumor metastasis, particularly in people of African ancestry. Epigenetic alterations, such as DNA methylation, histone modifications, alterations in non-coding RNAs, and mRNA methylation, significantly influence gene expre...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1325614/full |
| _version_ | 1797301180945137664 |
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| author | Elijah Kolawole Oladipo Elijah Kolawole Oladipo Seun Elijah Olufemi Seun Elijah Olufemi Daniel Adewole Adediran Daniel Adewole Adediran Isaac Oluseun Adejumo Esther Moderayo Jimah Julius Kola Oloke Julius Kola Oloke Chinedum C. Udekwu Olorunseun O. Ogunwobi |
| author_facet | Elijah Kolawole Oladipo Elijah Kolawole Oladipo Seun Elijah Olufemi Seun Elijah Olufemi Daniel Adewole Adediran Daniel Adewole Adediran Isaac Oluseun Adejumo Esther Moderayo Jimah Julius Kola Oloke Julius Kola Oloke Chinedum C. Udekwu Olorunseun O. Ogunwobi |
| author_sort | Elijah Kolawole Oladipo |
| collection | DOAJ |
| description | This review focuses on the critical role of epigenetic modifications in solid tumor metastasis, particularly in people of African ancestry. Epigenetic alterations, such as DNA methylation, histone modifications, alterations in non-coding RNAs, and mRNA methylation, significantly influence gene expression, contributing to cancer development and progression. Despite the primary focus on populations of European, American, and Asian descent in most cancer research, this work emphasizes the importance of studying the unique genetic and epigenetic landscapes of African populations for a more inclusive approach in understanding and treating cancer. Insights from this review have the potential to pave the way for the development of effective, tailored treatments, and provide a richer resource for understanding cancer progression and metastasis. Specific focus was placed on the role of DNA methylation, histone modifications, non-coding RNAs, and mRNA methylation in solid tumor metastasis, including how these modifications contribute to the regulation of tumor suppressor genes and oncogenes, influence cellular pathways and signaling, and interact with the immune system. Moreover, this review elaborates on the development of epigenetic-targeted therapeutic strategies and the current advances in this field, highlighting the promising applications of these therapies in improving outcomes for African ancestry populations disproportionately affected by certain types of cancer. Nevertheless, this work acknowledges the challenges that lie ahead, particularly the under-representation of African populations in cancer genomic and epigenomic studies and the technical complications associated with detecting subtle epigenetic modifications. Emphasis is placed on the necessity for more inclusive research practices, the development of more robust and sensitive methods for detecting and interpreting epigenetic changes, and the understanding of the interplay between genetic and epigenetic variations. The review concludes with an optimistic outlook on the future of epigenetic research in People of African ancestry, urging the concerted efforts of researchers, clinicians, funding agencies, and policymakers to extend the benefits of this research to all populations. |
| first_indexed | 2024-03-07T23:18:46Z |
| format | Article |
| id | doaj.art-3ba30ad86b614447a0664e4018145605 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-07T23:18:46Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-3ba30ad86b614447a0664e40181456052024-02-21T09:22:01ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-02-011410.3389/fonc.2024.13256141325614Epigenetic modifications in solid tumor metastasis in people of African ancestryElijah Kolawole Oladipo0Elijah Kolawole Oladipo1Seun Elijah Olufemi2Seun Elijah Olufemi3Daniel Adewole Adediran4Daniel Adewole Adediran5Isaac Oluseun Adejumo6Esther Moderayo Jimah7Julius Kola Oloke8Julius Kola Oloke9Chinedum C. Udekwu10Olorunseun O. Ogunwobi11Genomics Unit, Helix Biogen Institute, Ogbomoso, Oyo, NigeriaLaboratory of Molecular Biology, Immunology and Bioinformatics, Adeleke University, Ede, Osun State, NigeriaGenomics Unit, Helix Biogen Institute, Ogbomoso, Oyo, NigeriaDepartment of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Oyo, NigeriaGenomics Unit, Helix Biogen Institute, Ogbomoso, Oyo, NigeriaDepartment of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Oyo, NigeriaGenomics Unit, Helix Biogen Institute, Ogbomoso, Oyo, NigeriaGenomics Unit, Helix Biogen Institute, Ogbomoso, Oyo, NigeriaGenomics Unit, Helix Biogen Institute, Ogbomoso, Oyo, NigeriaDepartment of Natural Sciences, Precious Cornerstone University, Ibadan, NigeriaDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, United StatesDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, United StatesThis review focuses on the critical role of epigenetic modifications in solid tumor metastasis, particularly in people of African ancestry. Epigenetic alterations, such as DNA methylation, histone modifications, alterations in non-coding RNAs, and mRNA methylation, significantly influence gene expression, contributing to cancer development and progression. Despite the primary focus on populations of European, American, and Asian descent in most cancer research, this work emphasizes the importance of studying the unique genetic and epigenetic landscapes of African populations for a more inclusive approach in understanding and treating cancer. Insights from this review have the potential to pave the way for the development of effective, tailored treatments, and provide a richer resource for understanding cancer progression and metastasis. Specific focus was placed on the role of DNA methylation, histone modifications, non-coding RNAs, and mRNA methylation in solid tumor metastasis, including how these modifications contribute to the regulation of tumor suppressor genes and oncogenes, influence cellular pathways and signaling, and interact with the immune system. Moreover, this review elaborates on the development of epigenetic-targeted therapeutic strategies and the current advances in this field, highlighting the promising applications of these therapies in improving outcomes for African ancestry populations disproportionately affected by certain types of cancer. Nevertheless, this work acknowledges the challenges that lie ahead, particularly the under-representation of African populations in cancer genomic and epigenomic studies and the technical complications associated with detecting subtle epigenetic modifications. Emphasis is placed on the necessity for more inclusive research practices, the development of more robust and sensitive methods for detecting and interpreting epigenetic changes, and the understanding of the interplay between genetic and epigenetic variations. The review concludes with an optimistic outlook on the future of epigenetic research in People of African ancestry, urging the concerted efforts of researchers, clinicians, funding agencies, and policymakers to extend the benefits of this research to all populations.https://www.frontiersin.org/articles/10.3389/fonc.2024.1325614/fullAfrican ancestrycancerDNA methylationepigeneticshistone modificationssolid tumor |
| spellingShingle | Elijah Kolawole Oladipo Elijah Kolawole Oladipo Seun Elijah Olufemi Seun Elijah Olufemi Daniel Adewole Adediran Daniel Adewole Adediran Isaac Oluseun Adejumo Esther Moderayo Jimah Julius Kola Oloke Julius Kola Oloke Chinedum C. Udekwu Olorunseun O. Ogunwobi Epigenetic modifications in solid tumor metastasis in people of African ancestry Frontiers in Oncology African ancestry cancer DNA methylation epigenetics histone modifications solid tumor |
| title | Epigenetic modifications in solid tumor metastasis in people of African ancestry |
| title_full | Epigenetic modifications in solid tumor metastasis in people of African ancestry |
| title_fullStr | Epigenetic modifications in solid tumor metastasis in people of African ancestry |
| title_full_unstemmed | Epigenetic modifications in solid tumor metastasis in people of African ancestry |
| title_short | Epigenetic modifications in solid tumor metastasis in people of African ancestry |
| title_sort | epigenetic modifications in solid tumor metastasis in people of african ancestry |
| topic | African ancestry cancer DNA methylation epigenetics histone modifications solid tumor |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1325614/full |
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