S100A11 regulates renal carcinoma cell proliferation, invasion, and migration via the EGFR/Akt signaling pathway and E-cadherin
S100A11 is a S100 protein family member that contributes to cancer progression. Upregulated in human renal cancer tissues, S100A11 may be a prognostic marker for clear cell renal cell carcinoma, but how it functions in cancer is uncertain. Thus, we studied S100A11 and noted knockdown of S100A11 usin...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IOS Press
2017-05-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317705337 |
| _version_ | 1818878543819440128 |
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| author | Lin Liu Long Miao Yang Liu Aihua Qi Ping Xie Jiacun Chen Haitao Zhu |
| author_facet | Lin Liu Long Miao Yang Liu Aihua Qi Ping Xie Jiacun Chen Haitao Zhu |
| author_sort | Lin Liu |
| collection | DOAJ |
| description | S100A11 is a S100 protein family member that contributes to cancer progression. Upregulated in human renal cancer tissues, S100A11 may be a prognostic marker for clear cell renal cell carcinoma, but how it functions in cancer is uncertain. Thus, we studied S100A11 and noted knockdown of S100A11 using short hairpin RNA, which inhibited proliferation, invasion, and migration of renal carcinoma cells as well as increased expression of E-cadherin and decreased expression of epidermal growth factor receptor/Akt in renal carcinoma cells. Therefore, S100A11 may be a key molecular target for treating renal carcinoma. |
| first_indexed | 2024-12-19T14:15:51Z |
| format | Article |
| id | doaj.art-3ba34ca7ab214a7a9da19a20d81432ac |
| institution | Directory Open Access Journal |
| issn | 1423-0380 |
| language | English |
| last_indexed | 2024-12-19T14:15:51Z |
| publishDate | 2017-05-01 |
| publisher | IOS Press |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj.art-3ba34ca7ab214a7a9da19a20d81432ac2022-12-21T20:18:00ZengIOS PressTumor Biology1423-03802017-05-013910.1177/1010428317705337S100A11 regulates renal carcinoma cell proliferation, invasion, and migration via the EGFR/Akt signaling pathway and E-cadherinLin Liu0Long Miao1Yang Liu2Aihua Qi3Ping Xie4Jiacun Chen5Haitao Zhu6Xinyi People’s Hospital, Xinyi, ChinaXuzhou Medical University, Xuzhou, ChinaXuzhou Medical University Affiliated Hospital, Xuzhou, ChinaXinyi People’s Hospital, Xinyi, ChinaHuai’an Hospital Affiliated of Xuzhou Medical University and Huai’an Second People’s Hospital, Huai’an, ChinaXuzhou Medical University Affiliated Hospital, Xuzhou, ChinaXuzhou Medical University Affiliated Hospital, Xuzhou, ChinaS100A11 is a S100 protein family member that contributes to cancer progression. Upregulated in human renal cancer tissues, S100A11 may be a prognostic marker for clear cell renal cell carcinoma, but how it functions in cancer is uncertain. Thus, we studied S100A11 and noted knockdown of S100A11 using short hairpin RNA, which inhibited proliferation, invasion, and migration of renal carcinoma cells as well as increased expression of E-cadherin and decreased expression of epidermal growth factor receptor/Akt in renal carcinoma cells. Therefore, S100A11 may be a key molecular target for treating renal carcinoma.https://doi.org/10.1177/1010428317705337 |
| spellingShingle | Lin Liu Long Miao Yang Liu Aihua Qi Ping Xie Jiacun Chen Haitao Zhu S100A11 regulates renal carcinoma cell proliferation, invasion, and migration via the EGFR/Akt signaling pathway and E-cadherin Tumor Biology |
| title | S100A11 regulates renal carcinoma cell proliferation, invasion, and migration via the EGFR/Akt signaling pathway and E-cadherin |
| title_full | S100A11 regulates renal carcinoma cell proliferation, invasion, and migration via the EGFR/Akt signaling pathway and E-cadherin |
| title_fullStr | S100A11 regulates renal carcinoma cell proliferation, invasion, and migration via the EGFR/Akt signaling pathway and E-cadherin |
| title_full_unstemmed | S100A11 regulates renal carcinoma cell proliferation, invasion, and migration via the EGFR/Akt signaling pathway and E-cadherin |
| title_short | S100A11 regulates renal carcinoma cell proliferation, invasion, and migration via the EGFR/Akt signaling pathway and E-cadherin |
| title_sort | s100a11 regulates renal carcinoma cell proliferation invasion and migration via the egfr akt signaling pathway and e cadherin |
| url | https://doi.org/10.1177/1010428317705337 |
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