Green Synthesis and Characterization of Silver Nanoparticles of <i>Psidium guajava</i> Leaf Extract and Evaluation for Its Antidiabetic Activity
Diabetes mellitus (DM) and its complications are a severe public health concern due to the high incidence, morbidity, and mortality rates. The present study aims to synthesize and characterize silver nanoparticles (AgNPs) using the aqueous leaf extract of <i>Psidium guajava</i> (PGE) for...
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MDPI AG
2022-07-01
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| Online Access: | https://www.mdpi.com/1420-3049/27/14/4336 |
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| author | Sreeharsha Nagaraja Syed Sagheer Ahmed Bharathi D. R. Prakash Goudanavar Rupesh Kumar M. Santosh Fattepur Girish Meravanige Arshia Shariff Predeepkumar Narayanappa Shiroorkar Mohammed Habeebuddin Mallikarjun Telsang |
| author_facet | Sreeharsha Nagaraja Syed Sagheer Ahmed Bharathi D. R. Prakash Goudanavar Rupesh Kumar M. Santosh Fattepur Girish Meravanige Arshia Shariff Predeepkumar Narayanappa Shiroorkar Mohammed Habeebuddin Mallikarjun Telsang |
| author_sort | Sreeharsha Nagaraja |
| collection | DOAJ |
| description | Diabetes mellitus (DM) and its complications are a severe public health concern due to the high incidence, morbidity, and mortality rates. The present study aims to synthesize and characterize silver nanoparticles (AgNPs) using the aqueous leaf extract of <i>Psidium guajava</i> (PGE) for investigating its antidiabetic activity. <i>Psidium guajava</i> silver nanoparticles (PGAg NPs) were prepared and characterized by various parameters. The in vivo study was conducted using PGE and PGAg NPs in Streptozotocin (STZ)-induced diabetic rats to assess their antidiabetic properties. STZ of 55 mg/kg was injected to induce diabetes. The PGE, PGAg NPs at a dose of 200 and 400 mg/kg and standard drug Metformin (100 mg/kg) were administered daily to diabetic rats for 21 days through the oral route. Blood glucose level, body weight changes, lipid profiles, and histopathology of the rats’ liver and pancreas were examined. In the diabetic rats, PGE and PGAg NPs produced a drastic decrease in the blood glucose level, preventing subsequent weight loss and ameliorating lipid profile parameters. The histopathological findings revealed the improvements in pancreas and liver cells due to the repercussion of PGE and PGAg NPs. A compelling effect was observed in all doses of PGE and PGAg NPs; however, PGAg NPs exhibited a more promising result. Thus, from the results, it is concluded that the synthesized PGAg NPs has potent antidiabetic activity due to its enhanced surface area and smaller particle size of nanoparticles. |
| first_indexed | 2024-03-09T13:18:15Z |
| format | Article |
| id | doaj.art-3ba609fa440345d18c56069215ea1d96 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T13:18:15Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-3ba609fa440345d18c56069215ea1d962023-11-30T21:32:34ZengMDPI AGMolecules1420-30492022-07-012714433610.3390/molecules27144336Green Synthesis and Characterization of Silver Nanoparticles of <i>Psidium guajava</i> Leaf Extract and Evaluation for Its Antidiabetic ActivitySreeharsha Nagaraja0Syed Sagheer Ahmed1Bharathi D. R.2Prakash Goudanavar3Rupesh Kumar M.4Santosh Fattepur5Girish Meravanige6Arshia Shariff7Predeepkumar Narayanappa Shiroorkar8Mohammed Habeebuddin9Mallikarjun Telsang10Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, BG Nagara, Mandya 571448, IndiaDepartment of Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, BG Nagara, Mandya 571448, IndiaDepartment of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, BG Nagara, Mandya 571448, IndiaDepartment of Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, BG Nagara, Mandya 571448, IndiaSchool of Pharmacy, Management and Science University, Seksyen 13, Shah Alam 40100, MalaysiaDepartment of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore 560035, IndiaDepartment of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Surgery, College of Medicine, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDiabetes mellitus (DM) and its complications are a severe public health concern due to the high incidence, morbidity, and mortality rates. The present study aims to synthesize and characterize silver nanoparticles (AgNPs) using the aqueous leaf extract of <i>Psidium guajava</i> (PGE) for investigating its antidiabetic activity. <i>Psidium guajava</i> silver nanoparticles (PGAg NPs) were prepared and characterized by various parameters. The in vivo study was conducted using PGE and PGAg NPs in Streptozotocin (STZ)-induced diabetic rats to assess their antidiabetic properties. STZ of 55 mg/kg was injected to induce diabetes. The PGE, PGAg NPs at a dose of 200 and 400 mg/kg and standard drug Metformin (100 mg/kg) were administered daily to diabetic rats for 21 days through the oral route. Blood glucose level, body weight changes, lipid profiles, and histopathology of the rats’ liver and pancreas were examined. In the diabetic rats, PGE and PGAg NPs produced a drastic decrease in the blood glucose level, preventing subsequent weight loss and ameliorating lipid profile parameters. The histopathological findings revealed the improvements in pancreas and liver cells due to the repercussion of PGE and PGAg NPs. A compelling effect was observed in all doses of PGE and PGAg NPs; however, PGAg NPs exhibited a more promising result. Thus, from the results, it is concluded that the synthesized PGAg NPs has potent antidiabetic activity due to its enhanced surface area and smaller particle size of nanoparticles.https://www.mdpi.com/1420-3049/27/14/4336<i>Psidium guajava</i>antidiabeticstreptozotocinsilver nanoparticlescharacterization |
| spellingShingle | Sreeharsha Nagaraja Syed Sagheer Ahmed Bharathi D. R. Prakash Goudanavar Rupesh Kumar M. Santosh Fattepur Girish Meravanige Arshia Shariff Predeepkumar Narayanappa Shiroorkar Mohammed Habeebuddin Mallikarjun Telsang Green Synthesis and Characterization of Silver Nanoparticles of <i>Psidium guajava</i> Leaf Extract and Evaluation for Its Antidiabetic Activity Molecules <i>Psidium guajava</i> antidiabetic streptozotocin silver nanoparticles characterization |
| title | Green Synthesis and Characterization of Silver Nanoparticles of <i>Psidium guajava</i> Leaf Extract and Evaluation for Its Antidiabetic Activity |
| title_full | Green Synthesis and Characterization of Silver Nanoparticles of <i>Psidium guajava</i> Leaf Extract and Evaluation for Its Antidiabetic Activity |
| title_fullStr | Green Synthesis and Characterization of Silver Nanoparticles of <i>Psidium guajava</i> Leaf Extract and Evaluation for Its Antidiabetic Activity |
| title_full_unstemmed | Green Synthesis and Characterization of Silver Nanoparticles of <i>Psidium guajava</i> Leaf Extract and Evaluation for Its Antidiabetic Activity |
| title_short | Green Synthesis and Characterization of Silver Nanoparticles of <i>Psidium guajava</i> Leaf Extract and Evaluation for Its Antidiabetic Activity |
| title_sort | green synthesis and characterization of silver nanoparticles of i psidium guajava i leaf extract and evaluation for its antidiabetic activity |
| topic | <i>Psidium guajava</i> antidiabetic streptozotocin silver nanoparticles characterization |
| url | https://www.mdpi.com/1420-3049/27/14/4336 |
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