Dietary Carbohydrate Intake, Dietary Glycemic Load and Outcomes of In Vitro Fertilization: Findings from an Observational Italian Cohort Study
In recent decades, increasing attention has been paid to the influence of diet on reproductive health. Carbohydrates in diet affect glucose metabolism and multiple evidences showed the key role of insulin sensitivity in regulating female fertility. We designed a prospective cohort study to investiga...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-05-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/12/6/1568 |
| _version_ | 1797566792890056704 |
|---|---|
| author | Stefania Antonia Noli Elena Ricci Sonia Cipriani Stefania Ferrari Marta Castiglioni Irene La Vecchia Edgardo Somigliana Fabio Parazzini |
| author_facet | Stefania Antonia Noli Elena Ricci Sonia Cipriani Stefania Ferrari Marta Castiglioni Irene La Vecchia Edgardo Somigliana Fabio Parazzini |
| author_sort | Stefania Antonia Noli |
| collection | DOAJ |
| description | In recent decades, increasing attention has been paid to the influence of diet on reproductive health. Carbohydrates in diet affect glucose metabolism and multiple evidences showed the key role of insulin sensitivity in regulating female fertility. We designed a prospective cohort study to investigate the relation between dietary carbohydrate intake, glycemic load (GL) and the outcomes of assisted reproduction. A population of 494 female partners of couples referring to an Italian Fertility Center and eligible for in vitro fertilization (IVF) were enrolled in the study. On the day of the oocyte retrieval, information on their diet was obtained using a validated food frequency questionnaire (FFQ). We calculated the relative risk and 95% confidence interval of embryo transfer, clinical pregnancy and live birth according to the following dietary exposures: GL, glycemic index (GI) as well as the daily carbohydrate and fiber intake. A multiple regression model was used to account for the confounders. After adjusting for age, college degree, body mass index (BMI), leisure physical activity and previous assisted reproduction techniques (ART) cycles, no significant association was observed between the considered dietary exposures and the IVF outcomes. The roles of GL, carbohydrate intake and GI were assessed in strata of the cause of infertility and body mass index and no relation emerged in this further analysis. We found no clear association between the dietary carbohydrate quantity and quality and IVF outcomes in a cohort of infertile Italian women. |
| first_indexed | 2024-03-10T19:32:32Z |
| format | Article |
| id | doaj.art-3ba686fbe9df4dbfa5de3a467c691128 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T19:32:32Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-3ba686fbe9df4dbfa5de3a467c6911282023-11-20T01:58:39ZengMDPI AGNutrients2072-66432020-05-01126156810.3390/nu12061568Dietary Carbohydrate Intake, Dietary Glycemic Load and Outcomes of In Vitro Fertilization: Findings from an Observational Italian Cohort StudyStefania Antonia Noli0Elena Ricci1Sonia Cipriani2Stefania Ferrari3Marta Castiglioni4Irene La Vecchia5Edgardo Somigliana6Fabio Parazzini7Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, ItalyFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, ItalyDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, ItalyDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, ItalyDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, ItalyIn recent decades, increasing attention has been paid to the influence of diet on reproductive health. Carbohydrates in diet affect glucose metabolism and multiple evidences showed the key role of insulin sensitivity in regulating female fertility. We designed a prospective cohort study to investigate the relation between dietary carbohydrate intake, glycemic load (GL) and the outcomes of assisted reproduction. A population of 494 female partners of couples referring to an Italian Fertility Center and eligible for in vitro fertilization (IVF) were enrolled in the study. On the day of the oocyte retrieval, information on their diet was obtained using a validated food frequency questionnaire (FFQ). We calculated the relative risk and 95% confidence interval of embryo transfer, clinical pregnancy and live birth according to the following dietary exposures: GL, glycemic index (GI) as well as the daily carbohydrate and fiber intake. A multiple regression model was used to account for the confounders. After adjusting for age, college degree, body mass index (BMI), leisure physical activity and previous assisted reproduction techniques (ART) cycles, no significant association was observed between the considered dietary exposures and the IVF outcomes. The roles of GL, carbohydrate intake and GI were assessed in strata of the cause of infertility and body mass index and no relation emerged in this further analysis. We found no clear association between the dietary carbohydrate quantity and quality and IVF outcomes in a cohort of infertile Italian women.https://www.mdpi.com/2072-6643/12/6/1568dietglycemic loadglycemic indexcarbohydratein vitro fertilizationassisted reproductive techniques |
| spellingShingle | Stefania Antonia Noli Elena Ricci Sonia Cipriani Stefania Ferrari Marta Castiglioni Irene La Vecchia Edgardo Somigliana Fabio Parazzini Dietary Carbohydrate Intake, Dietary Glycemic Load and Outcomes of In Vitro Fertilization: Findings from an Observational Italian Cohort Study Nutrients diet glycemic load glycemic index carbohydrate in vitro fertilization assisted reproductive techniques |
| title | Dietary Carbohydrate Intake, Dietary Glycemic Load and Outcomes of In Vitro Fertilization: Findings from an Observational Italian Cohort Study |
| title_full | Dietary Carbohydrate Intake, Dietary Glycemic Load and Outcomes of In Vitro Fertilization: Findings from an Observational Italian Cohort Study |
| title_fullStr | Dietary Carbohydrate Intake, Dietary Glycemic Load and Outcomes of In Vitro Fertilization: Findings from an Observational Italian Cohort Study |
| title_full_unstemmed | Dietary Carbohydrate Intake, Dietary Glycemic Load and Outcomes of In Vitro Fertilization: Findings from an Observational Italian Cohort Study |
| title_short | Dietary Carbohydrate Intake, Dietary Glycemic Load and Outcomes of In Vitro Fertilization: Findings from an Observational Italian Cohort Study |
| title_sort | dietary carbohydrate intake dietary glycemic load and outcomes of in vitro fertilization findings from an observational italian cohort study |
| topic | diet glycemic load glycemic index carbohydrate in vitro fertilization assisted reproductive techniques |
| url | https://www.mdpi.com/2072-6643/12/6/1568 |
| work_keys_str_mv | AT stefaniaantonianoli dietarycarbohydrateintakedietaryglycemicloadandoutcomesofinvitrofertilizationfindingsfromanobservationalitaliancohortstudy AT elenaricci dietarycarbohydrateintakedietaryglycemicloadandoutcomesofinvitrofertilizationfindingsfromanobservationalitaliancohortstudy AT soniacipriani dietarycarbohydrateintakedietaryglycemicloadandoutcomesofinvitrofertilizationfindingsfromanobservationalitaliancohortstudy AT stefaniaferrari dietarycarbohydrateintakedietaryglycemicloadandoutcomesofinvitrofertilizationfindingsfromanobservationalitaliancohortstudy AT martacastiglioni dietarycarbohydrateintakedietaryglycemicloadandoutcomesofinvitrofertilizationfindingsfromanobservationalitaliancohortstudy AT irenelavecchia dietarycarbohydrateintakedietaryglycemicloadandoutcomesofinvitrofertilizationfindingsfromanobservationalitaliancohortstudy AT edgardosomigliana dietarycarbohydrateintakedietaryglycemicloadandoutcomesofinvitrofertilizationfindingsfromanobservationalitaliancohortstudy AT fabioparazzini dietarycarbohydrateintakedietaryglycemicloadandoutcomesofinvitrofertilizationfindingsfromanobservationalitaliancohortstudy |