The effect of calcium in water hardness on digoxin plasma levels in an experimental rat model

BACKGROUND: Digoxin is a drug for ventricular rate control in atrial fibrillation (AF). The major challenge in digoxin therapy is to adjust the appropriate concentration range for this drug due to its narrow therapeutic index. Unique physiochemical properties of drinking water affect the pharmacolog...

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Bibliographic Details
Main Authors: Shabnam Shahsavand, Mohammad Moshirfar, Seyed Hassan Seyed-Sharifi, Mohammad Amin Younessi-Heravi, Reza Ghasemi, Morteza Valaei, Mohsen Yaghubi
Format: Article
Language:English
Published: Vesnu Publications 2020-09-01
Series:ARYA Atherosclerosis
Subjects:
Online Access:https://arya.mui.ac.ir/article_10748_6d6e4800343550c8a88d05a8281b6182.pdf