The Effect of Serum Calcium Levels on Uremic Encephalopathy in Patients with Acute Kidney Injury in the Emergency Department
<em>Background and objectives</em>: Uremic encephalopathy is the most important complication of renal failure and urgent dialysis treatment is required. Parathormone (PTH) contributes to the etiopathogenesis of uremic encephalopathy. PTH is a hormone that acts in the calcium balance in t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/55/5/204 |
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| author | Canan Akman Dilek Ülker Çakır Serkan Bakırdöğen Serdal Balcı |
| author_facet | Canan Akman Dilek Ülker Çakır Serkan Bakırdöğen Serdal Balcı |
| author_sort | Canan Akman |
| collection | DOAJ |
| description | <em>Background and objectives</em>: Uremic encephalopathy is the most important complication of renal failure and urgent dialysis treatment is required. Parathormone (PTH) contributes to the etiopathogenesis of uremic encephalopathy. PTH is a hormone that acts in the calcium balance in the organism. The aim of our study was to investigate the effect of serum adjusted and ionized calcium on the development of uremic encephalopathy in patients with acute renal injury (acute kidney injury network (AKIN) stage 3). <em>Materials and Methods:</em> Our study was supported by Canakkale Onsekiz Mart University Scientific Research Projects Unit (ID:1278). Three groups were formed for the study. The first group was acute renal failure AKIN stage 3 (N: 23), the second group was AKIN stage 3, and the patients who had emergency hemodialysis (N: 17) and the third group (N: 9) had AKIN stage 3 hemodialysis due to uremic encephalopathy. In these patient groups, 25-hydroxy vitamin D, PTH, calcium, albumin, urea, creatinine, and blood-gas-ionized calcium were observed in their serum during the first application. Calcium, albumin, urea, creatinine, and ionized calcium in blood gas were also examined in serum at 24th and 72th hours. Data were analyzed using SPSS version 19.0. Kruskal–Wallis test and Mann–Whitney U test were applied for the variables that did not comply with normal distribution. <i>p</i> < 0.005 was accepted statistically. Results: A statistically significant difference was found between the measurement creatinine values at the 24th and 72th hours of admission in AKIN stage 3 patients who applied to the emergency department (<i>p</i> = 0.008). A statistically significant difference was found in the measured calcium values (<i>p</i> = 0.013). A statistically significant difference was found in the measured ionized calcium values (<i>p</i> = 0.035). <em>Conclusions:</em> In our study, the effect of ionized calcium level on uremic encephalopathy in serum creatinine, calcium, and blood gas in patients presenting with acute renal injury, AKIN stage 3, was significant, but studies with new and large groups are needed. |
| first_indexed | 2024-03-12T11:12:27Z |
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| id | doaj.art-3baa5d909cf7477d87403de1c4c79090 |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T11:12:27Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-3baa5d909cf7477d87403de1c4c790902023-09-02T02:31:42ZengMDPI AGMedicina1010-660X2019-05-0155520410.3390/medicina55050204medicina55050204The Effect of Serum Calcium Levels on Uremic Encephalopathy in Patients with Acute Kidney Injury in the Emergency DepartmentCanan Akman0Dilek Ülker Çakır1Serkan Bakırdöğen2Serdal Balcı3Emergency Medicine Department, Çanakkale Onsekiz Mart University Faculty of Medicine, 17020 Çanakkale, TurkeyBiochemistry Department, Çanakkale Onsekiz Mart University Faculty of Medicine, 17020 Çanakkale, TurkeyInternal Medicine Department, Çanakkale Onsekiz Mart University Faculty of Medicine, 17020 Çanakkale, TurkeyŞırnak State Hospital, Emergency Service, 73000 Şırnak, Turkey<em>Background and objectives</em>: Uremic encephalopathy is the most important complication of renal failure and urgent dialysis treatment is required. Parathormone (PTH) contributes to the etiopathogenesis of uremic encephalopathy. PTH is a hormone that acts in the calcium balance in the organism. The aim of our study was to investigate the effect of serum adjusted and ionized calcium on the development of uremic encephalopathy in patients with acute renal injury (acute kidney injury network (AKIN) stage 3). <em>Materials and Methods:</em> Our study was supported by Canakkale Onsekiz Mart University Scientific Research Projects Unit (ID:1278). Three groups were formed for the study. The first group was acute renal failure AKIN stage 3 (N: 23), the second group was AKIN stage 3, and the patients who had emergency hemodialysis (N: 17) and the third group (N: 9) had AKIN stage 3 hemodialysis due to uremic encephalopathy. In these patient groups, 25-hydroxy vitamin D, PTH, calcium, albumin, urea, creatinine, and blood-gas-ionized calcium were observed in their serum during the first application. Calcium, albumin, urea, creatinine, and ionized calcium in blood gas were also examined in serum at 24th and 72th hours. Data were analyzed using SPSS version 19.0. Kruskal–Wallis test and Mann–Whitney U test were applied for the variables that did not comply with normal distribution. <i>p</i> < 0.005 was accepted statistically. Results: A statistically significant difference was found between the measurement creatinine values at the 24th and 72th hours of admission in AKIN stage 3 patients who applied to the emergency department (<i>p</i> = 0.008). A statistically significant difference was found in the measured calcium values (<i>p</i> = 0.013). A statistically significant difference was found in the measured ionized calcium values (<i>p</i> = 0.035). <em>Conclusions:</em> In our study, the effect of ionized calcium level on uremic encephalopathy in serum creatinine, calcium, and blood gas in patients presenting with acute renal injury, AKIN stage 3, was significant, but studies with new and large groups are needed.https://www.mdpi.com/1010-660X/55/5/204acute kidney injuryserum calciumuremic encephalopathy |
| spellingShingle | Canan Akman Dilek Ülker Çakır Serkan Bakırdöğen Serdal Balcı The Effect of Serum Calcium Levels on Uremic Encephalopathy in Patients with Acute Kidney Injury in the Emergency Department Medicina acute kidney injury serum calcium uremic encephalopathy |
| title | The Effect of Serum Calcium Levels on Uremic Encephalopathy in Patients with Acute Kidney Injury in the Emergency Department |
| title_full | The Effect of Serum Calcium Levels on Uremic Encephalopathy in Patients with Acute Kidney Injury in the Emergency Department |
| title_fullStr | The Effect of Serum Calcium Levels on Uremic Encephalopathy in Patients with Acute Kidney Injury in the Emergency Department |
| title_full_unstemmed | The Effect of Serum Calcium Levels on Uremic Encephalopathy in Patients with Acute Kidney Injury in the Emergency Department |
| title_short | The Effect of Serum Calcium Levels on Uremic Encephalopathy in Patients with Acute Kidney Injury in the Emergency Department |
| title_sort | effect of serum calcium levels on uremic encephalopathy in patients with acute kidney injury in the emergency department |
| topic | acute kidney injury serum calcium uremic encephalopathy |
| url | https://www.mdpi.com/1010-660X/55/5/204 |
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