Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila

Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila

Neuroregeneration is a dynamic process synergizing the functional outcomes of multiple signaling circuits. Channelrhodopsin-based optogenetics shows the feasibility of stimulating neural repair but does not pin down specific signaling cascades. Here, we utilized optogenetic systems, optoRaf and opto...

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Bibliographic Details
Main Authors: Qin Wang, Huaxun Fan, Feng Li, Savanna S Skeeters, Vishnu V Krishnamurthy, Yuanquan Song, Kai Zhang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
optogenetics
axon regeneration
Drosophila
dendritic arborization
sensory neurons
thermonociception
Online Access:https://elifesciences.org/articles/57395

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