Beauveria bassiana: a new N6-(2-hydroxyethyl)-adenosine–producing fungus
N6-(2-Hydroxyethyl)-adenosine (HEA), which was the first calcium antagonist derived from biological sources, has been intensively investigated because of its ability to inhibit tumour cell proliferation, restrain inflammation, protect kidneys and function as a sedative and insecticide. Up to now, th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-10-01
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| Series: | Mycology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21501203.2017.1375040 |
| _version_ | 1831678031863742464 |
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| author | Kuanbo Liu Fen Wang Wenzhao Wang Caihong Dong |
| author_facet | Kuanbo Liu Fen Wang Wenzhao Wang Caihong Dong |
| author_sort | Kuanbo Liu |
| collection | DOAJ |
| description | N6-(2-Hydroxyethyl)-adenosine (HEA), which was the first calcium antagonist derived from biological sources, has been intensively investigated because of its ability to inhibit tumour cell proliferation, restrain inflammation, protect kidneys and function as a sedative and insecticide. Up to now, the production of HEA has been detected only in a few species such as Cordyceps pruinosa, C. militaris and Isaria tenuipes. Here, we found a new HEA-producing fungus, which was identified as Beauveria bassiana based on morphological and phylogenetic characteristics. The HEA production was verified by reversed-phase high-performance liquid chromatography/mass spectrometry in this fungus. Moreover, HEA was also detected in the mycelia of two other B. bassiana strains from different origins, but not in the culture medium of all tested B. bassiana strains. The maximum production of HEA (0.8483 ± 0.0439 mg/g mycelia dry weight) was achieved on day 7. The fungal biomass and kinetics of HEA production exhibited similar trends over the duration of the culture period. This is the first report describing HEA production in B. bassiana, which suggests that this fungal strain may have new applications as a source of HEA. |
| first_indexed | 2024-12-20T04:52:50Z |
| format | Article |
| id | doaj.art-3bab2e7c724e4589bd30d972b868b16d |
| institution | Directory Open Access Journal |
| issn | 2150-1203 2150-1211 |
| language | English |
| last_indexed | 2024-12-20T04:52:50Z |
| publishDate | 2017-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Mycology |
| spelling | doaj.art-3bab2e7c724e4589bd30d972b868b16d2022-12-21T19:52:48ZengTaylor & Francis GroupMycology2150-12032150-12112017-10-018425926610.1080/21501203.2017.13750401375040Beauveria bassiana: a new N6-(2-hydroxyethyl)-adenosine–producing fungusKuanbo Liu0Fen Wang1Wenzhao Wang2Caihong Dong3Guizhou UniversityChinese Academy of SciencesChinese Academy of SciencesChinese Academy of SciencesN6-(2-Hydroxyethyl)-adenosine (HEA), which was the first calcium antagonist derived from biological sources, has been intensively investigated because of its ability to inhibit tumour cell proliferation, restrain inflammation, protect kidneys and function as a sedative and insecticide. Up to now, the production of HEA has been detected only in a few species such as Cordyceps pruinosa, C. militaris and Isaria tenuipes. Here, we found a new HEA-producing fungus, which was identified as Beauveria bassiana based on morphological and phylogenetic characteristics. The HEA production was verified by reversed-phase high-performance liquid chromatography/mass spectrometry in this fungus. Moreover, HEA was also detected in the mycelia of two other B. bassiana strains from different origins, but not in the culture medium of all tested B. bassiana strains. The maximum production of HEA (0.8483 ± 0.0439 mg/g mycelia dry weight) was achieved on day 7. The fungal biomass and kinetics of HEA production exhibited similar trends over the duration of the culture period. This is the first report describing HEA production in B. bassiana, which suggests that this fungal strain may have new applications as a source of HEA.http://dx.doi.org/10.1080/21501203.2017.1375040NucleosidesN-(2-hydroxyethyl)-adenosineBeauveria bassianaCordyceps |
| spellingShingle | Kuanbo Liu Fen Wang Wenzhao Wang Caihong Dong Beauveria bassiana: a new N6-(2-hydroxyethyl)-adenosine–producing fungus Mycology Nucleosides N-(2-hydroxyethyl)-adenosine Beauveria bassiana Cordyceps |
| title | Beauveria bassiana: a new N6-(2-hydroxyethyl)-adenosine–producing fungus |
| title_full | Beauveria bassiana: a new N6-(2-hydroxyethyl)-adenosine–producing fungus |
| title_fullStr | Beauveria bassiana: a new N6-(2-hydroxyethyl)-adenosine–producing fungus |
| title_full_unstemmed | Beauveria bassiana: a new N6-(2-hydroxyethyl)-adenosine–producing fungus |
| title_short | Beauveria bassiana: a new N6-(2-hydroxyethyl)-adenosine–producing fungus |
| title_sort | beauveria bassiana a new n6 2 hydroxyethyl adenosine producing fungus |
| topic | Nucleosides N-(2-hydroxyethyl)-adenosine Beauveria bassiana Cordyceps |
| url | http://dx.doi.org/10.1080/21501203.2017.1375040 |
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