The relationship between liver function and neurophysiological factors in depressed individuals: a cross-sectional study using an integrated “East meets West” medicine approach
Introduction:Depression is a common mental disorder worldwide. The pathology of depression may involve the dysregulation of neurotransmitters and immunity and produce genetic and environmental effects. Traditional Chinese Medicine (TCM) has been practiced for several thousand years and has a differe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1159785/full |
| _version_ | 1797830019667460096 |
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| author | Jiajia Ye Jiajia Ye Yunying Yu Raymond C. K. Chung Xiaowen Lian Xin Wang Wai Ming Cheung Hector W. H. Tsang Hector W. H. Tsang |
| author_facet | Jiajia Ye Jiajia Ye Yunying Yu Raymond C. K. Chung Xiaowen Lian Xin Wang Wai Ming Cheung Hector W. H. Tsang Hector W. H. Tsang |
| author_sort | Jiajia Ye |
| collection | DOAJ |
| description | Introduction:Depression is a common mental disorder worldwide. The pathology of depression may involve the dysregulation of neurotransmitters and immunity and produce genetic and environmental effects. Traditional Chinese Medicine (TCM) has been practiced for several thousand years and has a different understanding of depression compared to Western medicine. However, this approach has not been widely accepted by scientific communities as TCM mainly focuses on clinical practice.Methods:In this study, we conducted a cross-sectional study among 100 participants in a rehabilitation hospital to analyze the plausible pathways linking TCM-based liver function and depression, which we hypothesized in a prior theoretical review.Results:A significant relationship between adrenocorticotropic hormone and TCM-based liver function was found (r = 0.211, p = 0.041). Cortisol was significantly associated with norepinephrine (r = 0.243, p = 0.015) and adrenocorticotropic hormone (r = 0.302, p < 0.001). A positive significant relationship was also found between norepinephrine and adrenocorticotropic hormone (r = 0.272, p < 0.001). There was no significant relationship between the ratio from low frequency to high frequency and TCM-based liver function (p = 0.690).Discussion:These results suggest that TCM-based liver function can be interpreted using the hypothalamic-pituitary-adrenal axis. This is a pioneering study to examine the mechanisms of depression in relation to liver function by integrating Eastern and Western medical approaches. The findings of this study are valuable for a deeper understanding of depression and public education. |
| first_indexed | 2024-04-09T13:29:25Z |
| format | Article |
| id | doaj.art-3baf462ee7154a80965efd3429890672 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-09T13:29:25Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-3baf462ee7154a80965efd34298906722023-05-10T04:22:51ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-05-011410.3389/fpsyt.2023.11597851159785The relationship between liver function and neurophysiological factors in depressed individuals: a cross-sectional study using an integrated “East meets West” medicine approachJiajia Ye0Jiajia Ye1Yunying Yu2Raymond C. K. Chung3Xiaowen Lian4Xin Wang5Wai Ming Cheung6Hector W. H. Tsang7Hector W. H. Tsang8Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, ChinaDepartment of Rehabilitation Assessments, Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaDepartment of Sleep Medicine, Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaDepartment of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, ChinaDepartment of Rehabilitation Assessments, Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaDepartment of Clinical Laboratory, Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaFaculty of Education, The University of Hong Kong, Pokfulam, Hong Kong SAR, ChinaDepartment of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, ChinaResearch Centre for Chinese Medicine Inovation, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, ChinaIntroduction:Depression is a common mental disorder worldwide. The pathology of depression may involve the dysregulation of neurotransmitters and immunity and produce genetic and environmental effects. Traditional Chinese Medicine (TCM) has been practiced for several thousand years and has a different understanding of depression compared to Western medicine. However, this approach has not been widely accepted by scientific communities as TCM mainly focuses on clinical practice.Methods:In this study, we conducted a cross-sectional study among 100 participants in a rehabilitation hospital to analyze the plausible pathways linking TCM-based liver function and depression, which we hypothesized in a prior theoretical review.Results:A significant relationship between adrenocorticotropic hormone and TCM-based liver function was found (r = 0.211, p = 0.041). Cortisol was significantly associated with norepinephrine (r = 0.243, p = 0.015) and adrenocorticotropic hormone (r = 0.302, p < 0.001). A positive significant relationship was also found between norepinephrine and adrenocorticotropic hormone (r = 0.272, p < 0.001). There was no significant relationship between the ratio from low frequency to high frequency and TCM-based liver function (p = 0.690).Discussion:These results suggest that TCM-based liver function can be interpreted using the hypothalamic-pituitary-adrenal axis. This is a pioneering study to examine the mechanisms of depression in relation to liver function by integrating Eastern and Western medical approaches. The findings of this study are valuable for a deeper understanding of depression and public education.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1159785/fulltraditional Chinese medicine (TCM)depressionliver functioncortisolheart rate variability (HRV)the hypothalamic–pituitary–adrenal (HPA) axis |
| spellingShingle | Jiajia Ye Jiajia Ye Yunying Yu Raymond C. K. Chung Xiaowen Lian Xin Wang Wai Ming Cheung Hector W. H. Tsang Hector W. H. Tsang The relationship between liver function and neurophysiological factors in depressed individuals: a cross-sectional study using an integrated “East meets West” medicine approach Frontiers in Psychiatry traditional Chinese medicine (TCM) depression liver function cortisol heart rate variability (HRV) the hypothalamic–pituitary–adrenal (HPA) axis |
| title | The relationship between liver function and neurophysiological factors in depressed individuals: a cross-sectional study using an integrated “East meets West” medicine approach |
| title_full | The relationship between liver function and neurophysiological factors in depressed individuals: a cross-sectional study using an integrated “East meets West” medicine approach |
| title_fullStr | The relationship between liver function and neurophysiological factors in depressed individuals: a cross-sectional study using an integrated “East meets West” medicine approach |
| title_full_unstemmed | The relationship between liver function and neurophysiological factors in depressed individuals: a cross-sectional study using an integrated “East meets West” medicine approach |
| title_short | The relationship between liver function and neurophysiological factors in depressed individuals: a cross-sectional study using an integrated “East meets West” medicine approach |
| title_sort | relationship between liver function and neurophysiological factors in depressed individuals a cross sectional study using an integrated east meets west medicine approach |
| topic | traditional Chinese medicine (TCM) depression liver function cortisol heart rate variability (HRV) the hypothalamic–pituitary–adrenal (HPA) axis |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1159785/full |
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