The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands

The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands

The authors report the structural characterization of M4R selective allosteric agonist, compound-110, as well as agonist iperoxo and positive allosteric modulator LY2119620. The cryo-EM structures of compound-110, iperoxo or iperoxo-LY2119620 bound M4R-Gi complex reveal different interaction modes a...

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Bibliographic Details
Main Authors:	Jingjing Wang, Meng Wu, Zhangcheng Chen, Lijie Wu, Tian Wang, Dongmei Cao, Huan Wang, Shenhui Liu, Yueming Xu, Fei Li, Junlin Liu, Na Chen, Suwen Zhao, Jianjun Cheng, Sheng Wang, Tian Hua
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-022-30595-y

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