A rare case of highly differentiated follicular carcinoma in ovary with FGFR4 Gly388Arg polymorphism: a case report and literature review
Abstract Background Highly differentiated follicular carcinoma (HDFCO) is a rare form of struma-derived thyroid-type carcinoma in ovary, defined as ovarian struma spreading beyond ovary but consisting of benign thyroid tissues. No more than 30 cases of HDFCO have been reported since it was first rec...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | Journal of Ovarian Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13048-022-01007-y |
| _version_ | 1797964735309676544 |
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| author | Yi-Ting Bao Chao Wang Wu Huang Liang-Qing Yao Lei Yuan |
| author_facet | Yi-Ting Bao Chao Wang Wu Huang Liang-Qing Yao Lei Yuan |
| author_sort | Yi-Ting Bao |
| collection | DOAJ |
| description | Abstract Background Highly differentiated follicular carcinoma (HDFCO) is a rare form of struma-derived thyroid-type carcinoma in ovary, defined as ovarian struma spreading beyond ovary but consisting of benign thyroid tissues. No more than 30 cases of HDFCO have been reported since it was first recognized in 2008. The clinicopathologic and molecular features of HDFCO remain unclear up till now. Case presentation A 38-year-old, para 1 gravida 5 woman has a long history of recurrent right ovarian cysts. Histological evaluation showed the tumor progressed from ovarian mature cystic teratoma (OMCT) to highly differentiated follicular carcinoma (HDFCO) during three relapses. Whole-exome sequencing revealed the germline FGFR4 Gly388Arg polymorphism. Repeated operations were performed to remove lesions for the first two relapses. On the third recurrence, the patient received radical surgery with subsequent thyroidectomy and radioactive iodine ablation. No evidence of disease was observed by February 2022 (8 months). Conclusions The germline FGFR4 Gly388Arg polymorphism may accelerate the malignant transformation of HDFCO, probably by working as a second hit in the developing spectrum. |
| first_indexed | 2024-04-11T01:48:36Z |
| format | Article |
| id | doaj.art-3bb55adcfb7947739e673d775bc4bb41 |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T01:48:36Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-3bb55adcfb7947739e673d775bc4bb412023-01-03T07:11:01ZengBMCJournal of Ovarian Research1757-22152022-06-011511710.1186/s13048-022-01007-yA rare case of highly differentiated follicular carcinoma in ovary with FGFR4 Gly388Arg polymorphism: a case report and literature reviewYi-Ting Bao0Chao Wang1Wu Huang2Liang-Qing Yao3Lei Yuan4Department of Gynecologic Oncology, Obstetrics and Gynecology Hospital of Fudan UniversityDepartment of Pathology, Obstetrics and Gynecology Hospital of Fudan UniversityDepartment of Gynecologic Oncology, Obstetrics and Gynecology Hospital of Fudan UniversityDepartment of Gynecologic Oncology, Obstetrics and Gynecology Hospital of Fudan UniversityDepartment of Gynecologic Oncology, Obstetrics and Gynecology Hospital of Fudan UniversityAbstract Background Highly differentiated follicular carcinoma (HDFCO) is a rare form of struma-derived thyroid-type carcinoma in ovary, defined as ovarian struma spreading beyond ovary but consisting of benign thyroid tissues. No more than 30 cases of HDFCO have been reported since it was first recognized in 2008. The clinicopathologic and molecular features of HDFCO remain unclear up till now. Case presentation A 38-year-old, para 1 gravida 5 woman has a long history of recurrent right ovarian cysts. Histological evaluation showed the tumor progressed from ovarian mature cystic teratoma (OMCT) to highly differentiated follicular carcinoma (HDFCO) during three relapses. Whole-exome sequencing revealed the germline FGFR4 Gly388Arg polymorphism. Repeated operations were performed to remove lesions for the first two relapses. On the third recurrence, the patient received radical surgery with subsequent thyroidectomy and radioactive iodine ablation. No evidence of disease was observed by February 2022 (8 months). Conclusions The germline FGFR4 Gly388Arg polymorphism may accelerate the malignant transformation of HDFCO, probably by working as a second hit in the developing spectrum.https://doi.org/10.1186/s13048-022-01007-yHighly differentiated follicular carcinoma (HDFCO)Malignant struma ovariiFGFR4 Gly388ArgMutation |
| spellingShingle | Yi-Ting Bao Chao Wang Wu Huang Liang-Qing Yao Lei Yuan A rare case of highly differentiated follicular carcinoma in ovary with FGFR4 Gly388Arg polymorphism: a case report and literature review Journal of Ovarian Research Highly differentiated follicular carcinoma (HDFCO) Malignant struma ovarii FGFR4 Gly388Arg Mutation |
| title | A rare case of highly differentiated follicular carcinoma in ovary with FGFR4 Gly388Arg polymorphism: a case report and literature review |
| title_full | A rare case of highly differentiated follicular carcinoma in ovary with FGFR4 Gly388Arg polymorphism: a case report and literature review |
| title_fullStr | A rare case of highly differentiated follicular carcinoma in ovary with FGFR4 Gly388Arg polymorphism: a case report and literature review |
| title_full_unstemmed | A rare case of highly differentiated follicular carcinoma in ovary with FGFR4 Gly388Arg polymorphism: a case report and literature review |
| title_short | A rare case of highly differentiated follicular carcinoma in ovary with FGFR4 Gly388Arg polymorphism: a case report and literature review |
| title_sort | rare case of highly differentiated follicular carcinoma in ovary with fgfr4 gly388arg polymorphism a case report and literature review |
| topic | Highly differentiated follicular carcinoma (HDFCO) Malignant struma ovarii FGFR4 Gly388Arg Mutation |
| url | https://doi.org/10.1186/s13048-022-01007-y |
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