Recent Progress in Amaryllidaceae Biotechnology
Plants belonging to the monocotyledonous Amaryllidaceae family include about 1100 species divided among 75 genera. They are well known as medicinal and ornamental plants, producing pharmaceutically important alkaloids, the most intensively investigated of which are galanthamine and lycorine. Amaryll...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/20/4670 |
| _version_ | 1797551126541762560 |
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| author | Vasil Georgiev Ivan Ivanov Atanas Pavlov |
| author_facet | Vasil Georgiev Ivan Ivanov Atanas Pavlov |
| author_sort | Vasil Georgiev |
| collection | DOAJ |
| description | Plants belonging to the monocotyledonous Amaryllidaceae family include about 1100 species divided among 75 genera. They are well known as medicinal and ornamental plants, producing pharmaceutically important alkaloids, the most intensively investigated of which are galanthamine and lycorine. Amaryllidaceae alkaloids possess various biological activities, the most important one being their anti-acetylcholinesterase activity, used for the treatment of Alzheimer’s disease. Due to increased demand for Amaryllidaceae alkaloids (mainly galanthamine) and the limited availability of plant sources, in vitro culture technology has attracted the attention of researchers as a prospective alternative for their sustainable production. Plant in vitro systems have been extensively used for continuous, sustainable, and economically viable production of bioactive plant secondary metabolites. Over the past two decades, a significant success has been demonstrated in the development of in vitro systems synthesizing Amaryllidaceae alkaloids. The present review discusses the state of the art of in vitro Amaryllidaceae alkaloids production, summarizing recently documented plant in vitro systems producing them, as well as the authors’ point of view on the development of biotechnological production processes with a focus on the future prospects of in vitro culture technology for the commercial production of these valuable alkaloids. |
| first_indexed | 2024-03-10T15:40:16Z |
| format | Article |
| id | doaj.art-3bb5e21bee2a46afa48e95bee00ce1a6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T15:40:16Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-3bb5e21bee2a46afa48e95bee00ce1a62023-11-20T16:54:34ZengMDPI AGMolecules1420-30492020-10-012520467010.3390/molecules25204670Recent Progress in Amaryllidaceae BiotechnologyVasil Georgiev0Ivan Ivanov1Atanas Pavlov2Laboratory of Cell Biosystems, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Plovdiv 4000, BulgariaDepartment of Organic Chemistry and Inorganic Chemistry, University of Food Technologies, Plovdiv 4002, BulgariaLaboratory of Cell Biosystems, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Plovdiv 4000, BulgariaPlants belonging to the monocotyledonous Amaryllidaceae family include about 1100 species divided among 75 genera. They are well known as medicinal and ornamental plants, producing pharmaceutically important alkaloids, the most intensively investigated of which are galanthamine and lycorine. Amaryllidaceae alkaloids possess various biological activities, the most important one being their anti-acetylcholinesterase activity, used for the treatment of Alzheimer’s disease. Due to increased demand for Amaryllidaceae alkaloids (mainly galanthamine) and the limited availability of plant sources, in vitro culture technology has attracted the attention of researchers as a prospective alternative for their sustainable production. Plant in vitro systems have been extensively used for continuous, sustainable, and economically viable production of bioactive plant secondary metabolites. Over the past two decades, a significant success has been demonstrated in the development of in vitro systems synthesizing Amaryllidaceae alkaloids. The present review discusses the state of the art of in vitro Amaryllidaceae alkaloids production, summarizing recently documented plant in vitro systems producing them, as well as the authors’ point of view on the development of biotechnological production processes with a focus on the future prospects of in vitro culture technology for the commercial production of these valuable alkaloids.https://www.mdpi.com/1420-3049/25/20/4670alkaloidsAmaryllidaceaebioreactorsgalanthamineplant in vitro systems |
| spellingShingle | Vasil Georgiev Ivan Ivanov Atanas Pavlov Recent Progress in Amaryllidaceae Biotechnology Molecules alkaloids Amaryllidaceae bioreactors galanthamine plant in vitro systems |
| title | Recent Progress in Amaryllidaceae Biotechnology |
| title_full | Recent Progress in Amaryllidaceae Biotechnology |
| title_fullStr | Recent Progress in Amaryllidaceae Biotechnology |
| title_full_unstemmed | Recent Progress in Amaryllidaceae Biotechnology |
| title_short | Recent Progress in Amaryllidaceae Biotechnology |
| title_sort | recent progress in amaryllidaceae biotechnology |
| topic | alkaloids Amaryllidaceae bioreactors galanthamine plant in vitro systems |
| url | https://www.mdpi.com/1420-3049/25/20/4670 |
| work_keys_str_mv | AT vasilgeorgiev recentprogressinamaryllidaceaebiotechnology AT ivanivanov recentprogressinamaryllidaceaebiotechnology AT atanaspavlov recentprogressinamaryllidaceaebiotechnology |