Atypical lobular endocervical glandular hyperplasia: two case report and literature review

Atypical lobular endocervical glandular hyperplasia (ALEGH) is considered a precancerous lesion of gastric-type adenocarcinoma (GAS)/minimal deviation adenocarcinoma (MDA) characterized by an insidious onset, atypical symptoms, and often negative human papillomavirus (HPV) screening. Early screening...

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Main Authors: Ziqing Wan, Shuang Liu, Na Sang, Yi Tang, Peng Wen, Pu Zhang, Chuqiang Shu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1298793/full
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author Ziqing Wan
Shuang Liu
Na Sang
Yi Tang
Peng Wen
Pu Zhang
Chuqiang Shu
author_facet Ziqing Wan
Shuang Liu
Na Sang
Yi Tang
Peng Wen
Pu Zhang
Chuqiang Shu
author_sort Ziqing Wan
collection DOAJ
description Atypical lobular endocervical glandular hyperplasia (ALEGH) is considered a precancerous lesion of gastric-type adenocarcinoma (GAS)/minimal deviation adenocarcinoma (MDA) characterized by an insidious onset, atypical symptoms, and often negative human papillomavirus (HPV) screening. Early screening for this disease is challenging, leading to a high rate of missed clinical diagnoses and the development of malignant tumors at the onset. Increased vaginal discharge and the presence of imaging cystic masses at the internal cervical ostium are often observed in patients with ALEGH. Therefore, we reviewed the clinical data of two cases of ALEGH that were identified and diagnosed in the early stages at our hospital. Through a comprehensive analysis of the medical history and diagnosis plan, combined with a review of relevant literature, to improve the early recognition and diagnosis of ALEGH, as well as strengthen the management of cervical precancerous lesions.
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spelling doaj.art-3bb6d7917db944bfb6232372b30633852023-12-05T04:53:14ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-12-011310.3389/fonc.2023.12987931298793Atypical lobular endocervical glandular hyperplasia: two case report and literature reviewZiqing WanShuang LiuNa SangYi TangPeng WenPu ZhangChuqiang ShuAtypical lobular endocervical glandular hyperplasia (ALEGH) is considered a precancerous lesion of gastric-type adenocarcinoma (GAS)/minimal deviation adenocarcinoma (MDA) characterized by an insidious onset, atypical symptoms, and often negative human papillomavirus (HPV) screening. Early screening for this disease is challenging, leading to a high rate of missed clinical diagnoses and the development of malignant tumors at the onset. Increased vaginal discharge and the presence of imaging cystic masses at the internal cervical ostium are often observed in patients with ALEGH. Therefore, we reviewed the clinical data of two cases of ALEGH that were identified and diagnosed in the early stages at our hospital. Through a comprehensive analysis of the medical history and diagnosis plan, combined with a review of relevant literature, to improve the early recognition and diagnosis of ALEGH, as well as strengthen the management of cervical precancerous lesions.https://www.frontiersin.org/articles/10.3389/fonc.2023.1298793/fullatypical lobular endocervical glandular hyperplasiagastric-type adenocarcinomahuman papillomaviruspathologydiagnosistherapy
spellingShingle Ziqing Wan
Shuang Liu
Na Sang
Yi Tang
Peng Wen
Pu Zhang
Chuqiang Shu
Atypical lobular endocervical glandular hyperplasia: two case report and literature review
Frontiers in Oncology
atypical lobular endocervical glandular hyperplasia
gastric-type adenocarcinoma
human papillomavirus
pathology
diagnosis
therapy
title Atypical lobular endocervical glandular hyperplasia: two case report and literature review
title_full Atypical lobular endocervical glandular hyperplasia: two case report and literature review
title_fullStr Atypical lobular endocervical glandular hyperplasia: two case report and literature review
title_full_unstemmed Atypical lobular endocervical glandular hyperplasia: two case report and literature review
title_short Atypical lobular endocervical glandular hyperplasia: two case report and literature review
title_sort atypical lobular endocervical glandular hyperplasia two case report and literature review
topic atypical lobular endocervical glandular hyperplasia
gastric-type adenocarcinoma
human papillomavirus
pathology
diagnosis
therapy
url https://www.frontiersin.org/articles/10.3389/fonc.2023.1298793/full
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