Exploring the Therapeutic Efficacy of Parsley (<i>Petroselinum crispum</i> Mill.) as a Functional Food: Implications in Immunological Tolerability, Reduction of Muscle Cramps, and Treatment of Dermatitis
The status of parsley as a well-known folk medicine noted for its nutritional and medicinal properties prompted the exploration of its potential as a functional food and natural remedy. The paper aims to investigate the potential of parsley to enhance muscle function and alleviate psoriasiform derma...
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| Format: | Article |
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MDPI AG
2024-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/3/608 |
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| author | Mariana Ganea Laura Grațiela Vicaș Octavia Gligor Ioan Sarac Emilian Onisan Csaba Nagy Corina Moisa Timea Claudia Ghitea |
| author_facet | Mariana Ganea Laura Grațiela Vicaș Octavia Gligor Ioan Sarac Emilian Onisan Csaba Nagy Corina Moisa Timea Claudia Ghitea |
| author_sort | Mariana Ganea |
| collection | DOAJ |
| description | The status of parsley as a well-known folk medicine noted for its nutritional and medicinal properties prompted the exploration of its potential as a functional food and natural remedy. The paper aims to investigate the potential of parsley to enhance muscle function and alleviate psoriasiform dermatitis, eventually establishing it as a natural, well-tolerated alternative with specific benefits for both muscles and skin. This study examines the tolerability of parsley in a cohort of 937 participants by assessing immunoglobulin G (IgG) reactions. The findings reveal high tolerability, as 96.26% of participants experienced no adverse effects. Among the 902 individuals lacking hypersensitivity, 37.02% reported muscle cramps, with a notable 15.02% reduction observed in the subgroup consuming parsley juice. In the subset of 32 subjects with dermatitis, the application of parsley extract ointment led to a significant decrease in dermatological parameters (redness, thickness, scaling). While the control group exhibited improvements, statistical significance was not observed. Notably, four categories of affected area reduction were identified, with scaling demonstrating the most pronounced impact. The results propose that parsley holds promise for favorable tolerability, contributing to the alleviation of muscle cramps and presenting an effective alternative in dermatitis treatment. Nonetheless, sustained validation through long-term studies is imperative to substantiate these preliminary findings. |
| first_indexed | 2024-03-08T03:51:34Z |
| format | Article |
| id | doaj.art-3bb805e81e584cef8a1e0751eaa4a9f1 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-08T03:51:34Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-3bb805e81e584cef8a1e0751eaa4a9f12024-02-09T15:18:49ZengMDPI AGMolecules1420-30492024-01-0129360810.3390/molecules29030608Exploring the Therapeutic Efficacy of Parsley (<i>Petroselinum crispum</i> Mill.) as a Functional Food: Implications in Immunological Tolerability, Reduction of Muscle Cramps, and Treatment of DermatitisMariana Ganea0Laura Grațiela Vicaș1Octavia Gligor2Ioan Sarac3Emilian Onisan4Csaba Nagy5Corina Moisa6Timea Claudia Ghitea7Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 1st Decembrie Street, 410073 Oradea, RomaniaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 1st Decembrie Street, 410073 Oradea, RomaniaFaculty of Pharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, RomaniaDepartment of Genetic Engineering, University of Life Sciences “King Mihai I Timișoara”, 300645 Timișoara, RomaniaDepartment of Genetic Engineering, University of Life Sciences “King Mihai I Timișoara”, 300645 Timișoara, RomaniaIndependent Researcher, 417595 Tinca, RomaniaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 1st Decembrie Street, 410073 Oradea, RomaniaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 1st Decembrie Street, 410073 Oradea, RomaniaThe status of parsley as a well-known folk medicine noted for its nutritional and medicinal properties prompted the exploration of its potential as a functional food and natural remedy. The paper aims to investigate the potential of parsley to enhance muscle function and alleviate psoriasiform dermatitis, eventually establishing it as a natural, well-tolerated alternative with specific benefits for both muscles and skin. This study examines the tolerability of parsley in a cohort of 937 participants by assessing immunoglobulin G (IgG) reactions. The findings reveal high tolerability, as 96.26% of participants experienced no adverse effects. Among the 902 individuals lacking hypersensitivity, 37.02% reported muscle cramps, with a notable 15.02% reduction observed in the subgroup consuming parsley juice. In the subset of 32 subjects with dermatitis, the application of parsley extract ointment led to a significant decrease in dermatological parameters (redness, thickness, scaling). While the control group exhibited improvements, statistical significance was not observed. Notably, four categories of affected area reduction were identified, with scaling demonstrating the most pronounced impact. The results propose that parsley holds promise for favorable tolerability, contributing to the alleviation of muscle cramps and presenting an effective alternative in dermatitis treatment. Nonetheless, sustained validation through long-term studies is imperative to substantiate these preliminary findings.https://www.mdpi.com/1420-3049/29/3/608<i>Petroselinum crispum</i> Mill.parsleyIgG reactionsdermatitismuscle cramps |
| spellingShingle | Mariana Ganea Laura Grațiela Vicaș Octavia Gligor Ioan Sarac Emilian Onisan Csaba Nagy Corina Moisa Timea Claudia Ghitea Exploring the Therapeutic Efficacy of Parsley (<i>Petroselinum crispum</i> Mill.) as a Functional Food: Implications in Immunological Tolerability, Reduction of Muscle Cramps, and Treatment of Dermatitis Molecules <i>Petroselinum crispum</i> Mill. parsley IgG reactions dermatitis muscle cramps |
| title | Exploring the Therapeutic Efficacy of Parsley (<i>Petroselinum crispum</i> Mill.) as a Functional Food: Implications in Immunological Tolerability, Reduction of Muscle Cramps, and Treatment of Dermatitis |
| title_full | Exploring the Therapeutic Efficacy of Parsley (<i>Petroselinum crispum</i> Mill.) as a Functional Food: Implications in Immunological Tolerability, Reduction of Muscle Cramps, and Treatment of Dermatitis |
| title_fullStr | Exploring the Therapeutic Efficacy of Parsley (<i>Petroselinum crispum</i> Mill.) as a Functional Food: Implications in Immunological Tolerability, Reduction of Muscle Cramps, and Treatment of Dermatitis |
| title_full_unstemmed | Exploring the Therapeutic Efficacy of Parsley (<i>Petroselinum crispum</i> Mill.) as a Functional Food: Implications in Immunological Tolerability, Reduction of Muscle Cramps, and Treatment of Dermatitis |
| title_short | Exploring the Therapeutic Efficacy of Parsley (<i>Petroselinum crispum</i> Mill.) as a Functional Food: Implications in Immunological Tolerability, Reduction of Muscle Cramps, and Treatment of Dermatitis |
| title_sort | exploring the therapeutic efficacy of parsley i petroselinum crispum i mill as a functional food implications in immunological tolerability reduction of muscle cramps and treatment of dermatitis |
| topic | <i>Petroselinum crispum</i> Mill. parsley IgG reactions dermatitis muscle cramps |
| url | https://www.mdpi.com/1420-3049/29/3/608 |
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