Historical and contemporary management of infantile hemangiomas: a single-center experience
Objective: This study explores the 22-year evolution of Infantile Hemangiomas (IHs) treatment strategies at a single-center hospital, aiming to establish an individualized IHs management protocol.Methods: Retrospective review of IHs infants 2000–2022 at the Department of Plastic Surgery, Jiangxi Pro...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1280948/full |
| _version_ | 1797334853096570880 |
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| author | Yun Zou Zhiping Wu Pingliang Jin Ronghua Fu Jun Cheng Hanxiang Bai Mengyu Huang Xiangqun Huang Hua Yuan |
| author_facet | Yun Zou Zhiping Wu Pingliang Jin Ronghua Fu Jun Cheng Hanxiang Bai Mengyu Huang Xiangqun Huang Hua Yuan |
| author_sort | Yun Zou |
| collection | DOAJ |
| description | Objective: This study explores the 22-year evolution of Infantile Hemangiomas (IHs) treatment strategies at a single-center hospital, aiming to establish an individualized IHs management protocol.Methods: Retrospective review of IHs infants 2000–2022 at the Department of Plastic Surgery, Jiangxi Provincial Children’s Hospital.Results: In our study of 27,513 IHs cases, 72.2% were female, with the median age at first hospital visit being 25 days. The majority of cases had localized and superficial lesions primarily on the head, face, and neck (67.5%). Ulceration rates fell from 21.1% to 12.6% with the introduction of propranolol. Management strategies have shifted over time, with the proportion of cases undergoing expectant management dropping from 32.9% to 12.4%. Since 2008, 26.1% of patients were treated with oral propranolol, largely replacing corticosteroids. Topical β-blockers have been used in 12.1% of cases, leading to a reduction in local injection therapy from 20.8% to 13.2%. Laser therapy, introduced in 2016, has been used in 13.8% of cases, while surgical excision has dropped from 25.0% to 8.5% due to alternative treatment options. Combination therapy was used in 8.8% of cases post-2015, indicating a rising trend. Drawing from the evolution of IHs management strategies, an individualized protocol for the management of IHs was successfully established.Conclusion: Treatment for IHs has evolved over recent decades, with less invasive medical interventions increasingly replacing more invasive methods. Furthermore, a personalized treatment protocol established in this study could boost the cure rate of IHs while minimizing potential side effects and complications. |
| first_indexed | 2024-03-08T08:28:15Z |
| format | Article |
| id | doaj.art-3bb9a26b9b48404daa56f33137d7d62e |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-08T08:28:15Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-3bb9a26b9b48404daa56f33137d7d62e2024-02-02T04:16:27ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-02-011510.3389/fphar.2024.12809481280948Historical and contemporary management of infantile hemangiomas: a single-center experienceYun ZouZhiping WuPingliang JinRonghua FuJun ChengHanxiang BaiMengyu HuangXiangqun HuangHua YuanObjective: This study explores the 22-year evolution of Infantile Hemangiomas (IHs) treatment strategies at a single-center hospital, aiming to establish an individualized IHs management protocol.Methods: Retrospective review of IHs infants 2000–2022 at the Department of Plastic Surgery, Jiangxi Provincial Children’s Hospital.Results: In our study of 27,513 IHs cases, 72.2% were female, with the median age at first hospital visit being 25 days. The majority of cases had localized and superficial lesions primarily on the head, face, and neck (67.5%). Ulceration rates fell from 21.1% to 12.6% with the introduction of propranolol. Management strategies have shifted over time, with the proportion of cases undergoing expectant management dropping from 32.9% to 12.4%. Since 2008, 26.1% of patients were treated with oral propranolol, largely replacing corticosteroids. Topical β-blockers have been used in 12.1% of cases, leading to a reduction in local injection therapy from 20.8% to 13.2%. Laser therapy, introduced in 2016, has been used in 13.8% of cases, while surgical excision has dropped from 25.0% to 8.5% due to alternative treatment options. Combination therapy was used in 8.8% of cases post-2015, indicating a rising trend. Drawing from the evolution of IHs management strategies, an individualized protocol for the management of IHs was successfully established.Conclusion: Treatment for IHs has evolved over recent decades, with less invasive medical interventions increasingly replacing more invasive methods. Furthermore, a personalized treatment protocol established in this study could boost the cure rate of IHs while minimizing potential side effects and complications.https://www.frontiersin.org/articles/10.3389/fphar.2024.1280948/fullinfantile hemangioma (IH)propranololvascular tissueneoplasmsB-blocker |
| spellingShingle | Yun Zou Zhiping Wu Pingliang Jin Ronghua Fu Jun Cheng Hanxiang Bai Mengyu Huang Xiangqun Huang Hua Yuan Historical and contemporary management of infantile hemangiomas: a single-center experience Frontiers in Pharmacology infantile hemangioma (IH) propranolol vascular tissue neoplasms B-blocker |
| title | Historical and contemporary management of infantile hemangiomas: a single-center experience |
| title_full | Historical and contemporary management of infantile hemangiomas: a single-center experience |
| title_fullStr | Historical and contemporary management of infantile hemangiomas: a single-center experience |
| title_full_unstemmed | Historical and contemporary management of infantile hemangiomas: a single-center experience |
| title_short | Historical and contemporary management of infantile hemangiomas: a single-center experience |
| title_sort | historical and contemporary management of infantile hemangiomas a single center experience |
| topic | infantile hemangioma (IH) propranolol vascular tissue neoplasms B-blocker |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1280948/full |
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