Role of Runx2 in Calcific Aortic Valve Disease in Mouse Models

Role of Runx2 in Calcific Aortic Valve Disease in Mouse Models

Background: Calcific aortic valve disease is common in the aging population and is characterized by the histological changes of the aortic valves including extracellular matrix remodeling, osteochondrogenic differentiation, and calcification. Combined, these changes lead to aortic sclerosis, aortic...

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Bibliographic Details
Main Authors: Subramanian Dharmarajan, Mei Y. Speer, Kate Pierce, Jake Lally, Elizabeth M. Leaf, Mu-En Lin, Marta Scatena, Cecilia M. Giachelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
RUNX2
CAVD
calcification
aortic valve stenosis
valve interstitial cells
osteochondrogenic differentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.687210/full

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