New Insights Into c.815_824dup Pathogenic Variant of BRCA1 in Inherited Breast Cancer: A Founder Mutation of West African Origin

New Insights Into c.815_824dup Pathogenic Variant of BRCA1 in Inherited Breast Cancer: A Founder Mutation of West African Origin

Founder mutations have been reported in BRCA1 and BCRA2 in different ethnic groups with inherited breast cancer. Testing of targeted mutations in specific populations is important for cancer prevention in mutation carriers. In Sub-Saharan Africa, only a few studies have reported specific founder mut...

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Bibliographic Details
Main Authors: Jean Pascal Demba Diop, Andréa Régina Gnilane Sène, Yacouba Dia, Seydi Abdoul Ba, Serigne Saliou Mbacke, Cheikh Ameth Tidiane Ly, Pierre Diaga Sarr, Doudou Diouf, Sidy Ka, Babacar Mbengue, Serigne Modou Kane Gueye, Pape Saloum Diop, Maguette Sylla Niang, Papa Madieye Gueye, Philomene Lopez Sall, Ahmadou Dem, Aynina Cisse, Alioune Dieye, Rokhaya Ndiaye
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Oncology
Subjects:
inherited breast cancer
BRCA1 gene
pathogenic variant
founder mutation
Africa
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.810060/full

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