Review of modern phlebotrophic preparations based on flavonoids as perspective endothelioprotectors in the treatment of chronic diseases of the veins
This review examines the development of endothelial dysfunction in chronic venous diseases (СVD), the multifactority of this process. The important role of the nitric oxide system as a universal modulator of various biochemical reactions and realization of many important physiological functions is...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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Remedium Group LTD
2019-04-01
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| Series: | Амбулаторная хирургия |
| Subjects: | |
| Online Access: | https://www.a-surgeon.ru/jour/article/view/133 |
| _version_ | 1797883979694604288 |
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| author | A. V. Voronkov O. Yu. Gamzeleva |
| author_facet | A. V. Voronkov O. Yu. Gamzeleva |
| author_sort | A. V. Voronkov |
| collection | DOAJ |
| description | This review examines the development of endothelial dysfunction in chronic venous diseases (СVD), the multifactority of this process. The important role of the nitric oxide system as a universal modulator of various biochemical reactions and realization of many important physiological functions is shown. The need for early pharmacotherapy of phleboprotectors with endothelioprotective activity is discussed in order to slow the progression of CVD. Effects of flavonoids as perspective endothelioprotectors on various links in the pathogenesis of endothelial dysfunction are considered. On the example of the micronized purified flavonoid fraction (MPFF), the effect of flavonoid compounds on endothelial dysfunction in CVD is demonstrated, and the mechanisms of action have been examined in detail. In addition, the pharmacological effects of individual components of the MPFF and their synergism in the focus on the effect on endothelial dysfunction are also discussed. Features of the micronized form that affect bioavailability and, ultimately, determine the pharmacological effectiveness of the drug are considered. |
| first_indexed | 2024-04-10T04:00:20Z |
| format | Article |
| id | doaj.art-3bbdb8015f294175acb43adece655361 |
| institution | Directory Open Access Journal |
| issn | 2712-8741 2782-2591 |
| language | Russian |
| last_indexed | 2024-04-10T04:00:20Z |
| publishDate | 2019-04-01 |
| publisher | Remedium Group LTD |
| record_format | Article |
| series | Амбулаторная хирургия |
| spelling | doaj.art-3bbdb8015f294175acb43adece6553612023-03-13T07:10:18ZrusRemedium Group LTDАмбулаторная хирургия2712-87412782-25912019-04-0101-2273310.21518/1995-1477-2019-1-2-27-33130Review of modern phlebotrophic preparations based on flavonoids as perspective endothelioprotectors in the treatment of chronic diseases of the veinsA. V. Voronkov0O. Yu. Gamzeleva1Пятигорский медико-фармацевтический институт – филиал государственного бюджетного образовательного учреждения высшего профессионального образования «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации»Пятигорский медико-фармацевтический институт – филиал государственного бюджетного образовательного учреждения высшего профессионального образования «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации»This review examines the development of endothelial dysfunction in chronic venous diseases (СVD), the multifactority of this process. The important role of the nitric oxide system as a universal modulator of various biochemical reactions and realization of many important physiological functions is shown. The need for early pharmacotherapy of phleboprotectors with endothelioprotective activity is discussed in order to slow the progression of CVD. Effects of flavonoids as perspective endothelioprotectors on various links in the pathogenesis of endothelial dysfunction are considered. On the example of the micronized purified flavonoid fraction (MPFF), the effect of flavonoid compounds on endothelial dysfunction in CVD is demonstrated, and the mechanisms of action have been examined in detail. In addition, the pharmacological effects of individual components of the MPFF and their synergism in the focus on the effect on endothelial dysfunction are also discussed. Features of the micronized form that affect bioavailability and, ultimately, determine the pharmacological effectiveness of the drug are considered.https://www.a-surgeon.ru/jour/article/view/133оксид азотаэндотелийхронические заболевания венфлебопротекторфлавоноидымоффдетралекс |
| spellingShingle | A. V. Voronkov O. Yu. Gamzeleva Review of modern phlebotrophic preparations based on flavonoids as perspective endothelioprotectors in the treatment of chronic diseases of the veins Амбулаторная хирургия оксид азота эндотелий хронические заболевания вен флебопротектор флавоноиды мофф детралекс |
| title | Review of modern phlebotrophic preparations based on flavonoids as perspective endothelioprotectors in the treatment of chronic diseases of the veins |
| title_full | Review of modern phlebotrophic preparations based on flavonoids as perspective endothelioprotectors in the treatment of chronic diseases of the veins |
| title_fullStr | Review of modern phlebotrophic preparations based on flavonoids as perspective endothelioprotectors in the treatment of chronic diseases of the veins |
| title_full_unstemmed | Review of modern phlebotrophic preparations based on flavonoids as perspective endothelioprotectors in the treatment of chronic diseases of the veins |
| title_short | Review of modern phlebotrophic preparations based on flavonoids as perspective endothelioprotectors in the treatment of chronic diseases of the veins |
| title_sort | review of modern phlebotrophic preparations based on flavonoids as perspective endothelioprotectors in the treatment of chronic diseases of the veins |
| topic | оксид азота эндотелий хронические заболевания вен флебопротектор флавоноиды мофф детралекс |
| url | https://www.a-surgeon.ru/jour/article/view/133 |
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