Role of Ajwa dates in ameliorating diclofenac sodium-induced nephrotoxicity and cardiovascular risk factors in mice
The study aims at evaluating the protective effects of Ajwa dates extract against diclofenac sodium (DFS)-induced nephrotoxicity. A total of 30 male albino mice were divided into three groups. Group 1 received water per oral gavage for 14 days and saline per intra-peritoneal (IP) dose for the days 1...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-07-01
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| Series: | European Journal of Inflammation |
| Online Access: | https://doi.org/10.1177/2058739219861570 |
| _version_ | 1818300647595835392 |
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| author | Heba M Eltahir Naif Aljuhani Sara A Alsubhi Ghada M Alahmadi Hossein M Elbadawy Mekky M Abouzied |
| author_facet | Heba M Eltahir Naif Aljuhani Sara A Alsubhi Ghada M Alahmadi Hossein M Elbadawy Mekky M Abouzied |
| author_sort | Heba M Eltahir |
| collection | DOAJ |
| description | The study aims at evaluating the protective effects of Ajwa dates extract against diclofenac sodium (DFS)-induced nephrotoxicity. A total of 30 male albino mice were divided into three groups. Group 1 received water per oral gavage for 14 days and saline per intra-peritoneal (IP) dose for the days 12–14. Group 2 received water like Group 1 and a daily IP dose of DFS for the days 12–14. Group 3 received 1 gm/kg Ajwa extract in water for 14 days and a daily IP dose for the days 12–14. Biochemical investigation revealed DFS-induced increase in serum urea and creatinine levels along with depleted antioxidant capacity, altered lipid profile, and hyperglycemia. Ajwa extract successfully protected against DFS-induced adverse effects, normalizing renal parameters biochemically and histologically, and prevented its hyperlipidemic and hyperglycemic effects. Ajwa protected against endogenous antioxidant capacity depletion in treated animals. Hydroalcoholic Ajwa extract is a promising candidate for protection against DFS-induced hyperlipidemia and nephrotoxicity. |
| first_indexed | 2024-12-13T05:10:27Z |
| format | Article |
| id | doaj.art-3bbdc152d2e148f3b8c2723bdc827939 |
| institution | Directory Open Access Journal |
| issn | 2058-7392 |
| language | English |
| last_indexed | 2024-12-13T05:10:27Z |
| publishDate | 2019-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | European Journal of Inflammation |
| spelling | doaj.art-3bbdc152d2e148f3b8c2723bdc8279392022-12-21T23:58:32ZengSAGE PublishingEuropean Journal of Inflammation2058-73922019-07-011710.1177/2058739219861570Role of Ajwa dates in ameliorating diclofenac sodium-induced nephrotoxicity and cardiovascular risk factors in miceHeba M Eltahir0Naif Aljuhani1Sara A Alsubhi2Ghada M Alahmadi3Hossein M Elbadawy4Mekky M Abouzied5Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al-Madinah Al-Munawwarah, Kingdom of Saudi ArabiaDepartment of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al-Madinah Al-Munawwarah, Kingdom of Saudi ArabiaNephrotoxicity Research Team, College of Pharmacy, Taibah University, Al-Madinah Al-Munawwarah, Kingdom of Saudi ArabiaNephrotoxicity Research Team, College of Pharmacy, Taibah University, Al-Madinah Al-Munawwarah, Kingdom of Saudi ArabiaDepartment of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al-Madinah Al-Munawwarah, Kingdom of Saudi ArabiaDepartment of Biochemistry, Faculty of Pharmacy, Minia University, Minya, EgyptThe study aims at evaluating the protective effects of Ajwa dates extract against diclofenac sodium (DFS)-induced nephrotoxicity. A total of 30 male albino mice were divided into three groups. Group 1 received water per oral gavage for 14 days and saline per intra-peritoneal (IP) dose for the days 12–14. Group 2 received water like Group 1 and a daily IP dose of DFS for the days 12–14. Group 3 received 1 gm/kg Ajwa extract in water for 14 days and a daily IP dose for the days 12–14. Biochemical investigation revealed DFS-induced increase in serum urea and creatinine levels along with depleted antioxidant capacity, altered lipid profile, and hyperglycemia. Ajwa extract successfully protected against DFS-induced adverse effects, normalizing renal parameters biochemically and histologically, and prevented its hyperlipidemic and hyperglycemic effects. Ajwa protected against endogenous antioxidant capacity depletion in treated animals. Hydroalcoholic Ajwa extract is a promising candidate for protection against DFS-induced hyperlipidemia and nephrotoxicity.https://doi.org/10.1177/2058739219861570 |
| spellingShingle | Heba M Eltahir Naif Aljuhani Sara A Alsubhi Ghada M Alahmadi Hossein M Elbadawy Mekky M Abouzied Role of Ajwa dates in ameliorating diclofenac sodium-induced nephrotoxicity and cardiovascular risk factors in mice European Journal of Inflammation |
| title | Role of Ajwa dates in ameliorating diclofenac sodium-induced nephrotoxicity and cardiovascular risk factors in mice |
| title_full | Role of Ajwa dates in ameliorating diclofenac sodium-induced nephrotoxicity and cardiovascular risk factors in mice |
| title_fullStr | Role of Ajwa dates in ameliorating diclofenac sodium-induced nephrotoxicity and cardiovascular risk factors in mice |
| title_full_unstemmed | Role of Ajwa dates in ameliorating diclofenac sodium-induced nephrotoxicity and cardiovascular risk factors in mice |
| title_short | Role of Ajwa dates in ameliorating diclofenac sodium-induced nephrotoxicity and cardiovascular risk factors in mice |
| title_sort | role of ajwa dates in ameliorating diclofenac sodium induced nephrotoxicity and cardiovascular risk factors in mice |
| url | https://doi.org/10.1177/2058739219861570 |
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