Possible mechanism of schizophrenia origin by excess GABA and synaptic pruning
Schizophrenia is a psychotic disorder that affects approximately 1% of the global population. However, the etiology of this illness remains a subject of debate. One of the proposed mechanisms underlying schizophrenia is the synaptic pruning mediated by microglia in the brains of individuals with sch...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | IBRO Neuroscience Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242123000611 |
| _version_ | 1797383647910690816 |
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| author | A. Rabinovitch D. Braunstein R. Rabinovitch Y. Biton |
| author_facet | A. Rabinovitch D. Braunstein R. Rabinovitch Y. Biton |
| author_sort | A. Rabinovitch |
| collection | DOAJ |
| description | Schizophrenia is a psychotic disorder that affects approximately 1% of the global population. However, the etiology of this illness remains a subject of debate. One of the proposed mechanisms underlying schizophrenia is the synaptic pruning mediated by microglia in the brains of individuals with schizophrenia, although the precise mechanisms of this process remain elusive. In this regard, we propose that the potential development of the disease stems from both a genetic predisposition leading to an excessive production of GABAergic neurons and an exaggerated effort to maintain the E/I (excitation/inhibition) balance in the brain. |
| first_indexed | 2024-03-08T21:24:05Z |
| format | Article |
| id | doaj.art-3bbea8aec3df4791a5d712cdfb8e4a09 |
| institution | Directory Open Access Journal |
| issn | 2667-2421 |
| language | English |
| last_indexed | 2024-03-08T21:24:05Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj.art-3bbea8aec3df4791a5d712cdfb8e4a092023-12-21T07:38:27ZengElsevierIBRO Neuroscience Reports2667-24212023-12-0115126130Possible mechanism of schizophrenia origin by excess GABA and synaptic pruningA. Rabinovitch0D. Braunstein1R. Rabinovitch2Y. Biton3Physics Dept. Ben-Gurion University, Beer-Sheva, Israel; Corresponding author.Physics Dept. Sami Shamoon College of Engineering, Beer-Sheva, IsraelMakif YudAlef, Rishon Lezion, IsraelPhysics Dept. Ben-Gurion University, Beer-Sheva, IsraelSchizophrenia is a psychotic disorder that affects approximately 1% of the global population. However, the etiology of this illness remains a subject of debate. One of the proposed mechanisms underlying schizophrenia is the synaptic pruning mediated by microglia in the brains of individuals with schizophrenia, although the precise mechanisms of this process remain elusive. In this regard, we propose that the potential development of the disease stems from both a genetic predisposition leading to an excessive production of GABAergic neurons and an exaggerated effort to maintain the E/I (excitation/inhibition) balance in the brain.http://www.sciencedirect.com/science/article/pii/S2667242123000611SchizophreniaGABA synaptic pruning |
| spellingShingle | A. Rabinovitch D. Braunstein R. Rabinovitch Y. Biton Possible mechanism of schizophrenia origin by excess GABA and synaptic pruning IBRO Neuroscience Reports Schizophrenia GABA synaptic pruning |
| title | Possible mechanism of schizophrenia origin by excess GABA and synaptic pruning |
| title_full | Possible mechanism of schizophrenia origin by excess GABA and synaptic pruning |
| title_fullStr | Possible mechanism of schizophrenia origin by excess GABA and synaptic pruning |
| title_full_unstemmed | Possible mechanism of schizophrenia origin by excess GABA and synaptic pruning |
| title_short | Possible mechanism of schizophrenia origin by excess GABA and synaptic pruning |
| title_sort | possible mechanism of schizophrenia origin by excess gaba and synaptic pruning |
| topic | Schizophrenia GABA synaptic pruning |
| url | http://www.sciencedirect.com/science/article/pii/S2667242123000611 |
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