Downregulation of GLYR1 contributes to microsatellite instability colorectal cancer by targeting p21 via the p38MAPK and PI3K/AKT pathways

Downregulation of GLYR1 contributes to microsatellite instability colorectal cancer by targeting p21 via the p38MAPK and PI3K/AKT pathways

Abstract Background GLYR1 has a high mutation frequency in microsatellite instability colorectal cancer (MSI CRC) and is presumed to be a novel tumor suppressor. However, the role of GLYR1 in tumors has never been studied. In particular, the downregulation of GLYR1 in MSI CRC is worthy of further in...

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Bibliographic Details
Main Authors:	Zhiyan Hu, Ting Long, Yidan Ma, Jiaxian Zhu, Lingfang Gao, Yan Zhong, Xia Wang, Xiaoyan Wang, Zuguo Li
Format:	Article
Language:	English
Published:	BMC 2020-05-01
Series:	Journal of Experimental & Clinical Cancer Research
Subjects:	GLYR1 Microsatellite instability colorectal cancer MLH1 p38MAPK PI3K/Akt p21
Online Access:	http://link.springer.com/article/10.1186/s13046-020-01578-y

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