Single-Nucleotide Polymorphisms in Genes Maintaining the Stability of Mitochondrial DNA Affect the Occurrence, Onset, Severity and Treatment of Major Depressive Disorder

Single-Nucleotide Polymorphisms in Genes Maintaining the Stability of Mitochondrial DNA Affect the Occurrence, Onset, Severity and Treatment of Major Depressive Disorder

One of the key features of major depressive disorder (MDD, depression) is increased oxidative stress manifested by elevated levels of mtROS, a hallmark of mitochondrial dysfunction, which can arise from mitochondrial DNA (mtDNA) damage. Thus, the current study explores possibility that the single-nu...

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Bibliographic Details
Main Authors: Piotr Czarny, Sylwia Ziółkowska, Łukasz Kołodziej, Cezary Watała, Paulina Wigner-Jeziorska, Katarzyna Bliźniewska-Kowalska, Katarzyna Wachowska, Małgorzata Gałecka, Ewelina Synowiec, Piotr Gałecki, Michał Bijak, Janusz Szemraj, Tomasz Śliwiński
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
oxidative stress
depression
DNA repair
DNA damage
mitochondrial DNA
gene polymorphism
Online Access:https://www.mdpi.com/1422-0067/24/19/14752

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