The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System
Lung diseases are among the leading causes of morbidity and mortality. Complement activation may prevent a variety of respiratory infections, but on the other hand, could exacerbate tissue damage or contribute to adverse side effects. In this review, the associations of factors specific for compleme...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.585243/full |
| _version_ | 1819115345260052480 |
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| author | Anna S. Świerzko Maciej Cedzyński |
| author_facet | Anna S. Świerzko Maciej Cedzyński |
| author_sort | Anna S. Świerzko |
| collection | DOAJ |
| description | Lung diseases are among the leading causes of morbidity and mortality. Complement activation may prevent a variety of respiratory infections, but on the other hand, could exacerbate tissue damage or contribute to adverse side effects. In this review, the associations of factors specific for complement activation via the lectin pathway (LP) with infections of the respiratory system, from birth to adulthood, are discussed. The most extensive data concern mannose-binding lectin (MBL) which together with other collectins (collectin-10, collectin-11) and the ficolins (ficolin-1, ficolin-2, ficolin-3) belong to pattern-recognition molecules (PRM) specific for the LP. Those PRM form complexes with MBL-associated serine proteases (MASP-1, MASP-2, MASP-3) and related non-enzymatic factors (MAp19, MAp44). Beside diseases affecting humanity for centuries like tuberculosis or neonatal pneumonia, some recently published data concerning COVID-19 are summarized. |
| first_indexed | 2024-12-22T04:59:43Z |
| format | Article |
| id | doaj.art-3bc7db3a4461492c9967b62cc83ee562 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T04:59:43Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-3bc7db3a4461492c9967b62cc83ee5622022-12-21T18:38:18ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-10-011110.3389/fimmu.2020.585243585243The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory SystemAnna S. ŚwierzkoMaciej CedzyńskiLung diseases are among the leading causes of morbidity and mortality. Complement activation may prevent a variety of respiratory infections, but on the other hand, could exacerbate tissue damage or contribute to adverse side effects. In this review, the associations of factors specific for complement activation via the lectin pathway (LP) with infections of the respiratory system, from birth to adulthood, are discussed. The most extensive data concern mannose-binding lectin (MBL) which together with other collectins (collectin-10, collectin-11) and the ficolins (ficolin-1, ficolin-2, ficolin-3) belong to pattern-recognition molecules (PRM) specific for the LP. Those PRM form complexes with MBL-associated serine proteases (MASP-1, MASP-2, MASP-3) and related non-enzymatic factors (MAp19, MAp44). Beside diseases affecting humanity for centuries like tuberculosis or neonatal pneumonia, some recently published data concerning COVID-19 are summarized.https://www.frontiersin.org/articles/10.3389/fimmu.2020.585243/fullcollectincomplementficolinMASPmannose-binding lectinrespiratory infection |
| spellingShingle | Anna S. Świerzko Maciej Cedzyński The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System Frontiers in Immunology collectin complement ficolin MASP mannose-binding lectin respiratory infection |
| title | The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System |
| title_full | The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System |
| title_fullStr | The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System |
| title_full_unstemmed | The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System |
| title_short | The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System |
| title_sort | influence of the lectin pathway of complement activation on infections of the respiratory system |
| topic | collectin complement ficolin MASP mannose-binding lectin respiratory infection |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2020.585243/full |
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