Genomic analysis of matrix metalloproteinases affecting the prognosis and immunogenic profile of gastric cancer
This study systematically and comprehensively analyzed the characteristics of matrix metalloproteinases (MMPs) in gastric cancer (GC) and revealed the relationship between MMPs and prognoses, clinicopathological features, tumor microenvironment, gene mutations, and drug therapy response in patients...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2023.1128088/full |
| _version_ | 1797829747894386688 |
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| author | Chaofeng Yuan Jialin Yuan Huijie Xiao Haitao Li Yang Jiang Rongnan Zhai Jinjing Zhai Hua Xing Jiannan Huang |
| author_facet | Chaofeng Yuan Jialin Yuan Huijie Xiao Haitao Li Yang Jiang Rongnan Zhai Jinjing Zhai Hua Xing Jiannan Huang |
| author_sort | Chaofeng Yuan |
| collection | DOAJ |
| description | This study systematically and comprehensively analyzed the characteristics of matrix metalloproteinases (MMPs) in gastric cancer (GC) and revealed the relationship between MMPs and prognoses, clinicopathological features, tumor microenvironment, gene mutations, and drug therapy response in patients with GC. Based on the mRNA expression profiles of 45 MMP-related genes in GC, we established a model that classified GC patients into three groups based on cluster analysis of the mRNA expression profiles. The 3 groups of GC patients showed significantly different prognoses as well as tumor microenvironmental characteristics. Next, we used Boruta’s algorithm and PCA method to establish an MMP scoring system and found that lower MMP scores were associated with better prognoses, lower clinical stages, better immune cell infiltration, lower degrees of immune dysfunction and rejection, and more genetic mutations. Whereas a high MMP score was the opposite. These observations were further validated with data from other datasets, showing the robustness of our MMP scoring system. Overall, MMP could be involved in the tumor microenvironment (TME), clinical features, and prognosis of GC. An in-depth study of MMP patterns can better understand the indispensable role of MMP in the development of GC and reasonably assess the survival prognosis, clinicopathological features, and drug efficacy of different patients, thus providing clinicians with a broader vision of GC progression and treatment. |
| first_indexed | 2024-04-09T13:26:09Z |
| format | Article |
| id | doaj.art-3bc7deee197742c8b3784fea4b14c993 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-09T13:26:09Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-3bc7deee197742c8b3784fea4b14c9932023-05-10T09:00:45ZengFrontiers Media S.A.Frontiers in Genetics1664-80212023-04-011410.3389/fgene.2023.11280881128088Genomic analysis of matrix metalloproteinases affecting the prognosis and immunogenic profile of gastric cancerChaofeng Yuan0Jialin Yuan1Huijie Xiao2Haitao Li3Yang Jiang4Rongnan Zhai5Jinjing Zhai6Hua Xing7Jiannan Huang8Department of Gastrointestinal Colorectal Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Gastrointestinal Colorectal Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Gastrointestinal Colorectal Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Gastrointestinal Colorectal Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Gastrointestinal Colorectal Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Gastrointestinal Colorectal Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaThis study systematically and comprehensively analyzed the characteristics of matrix metalloproteinases (MMPs) in gastric cancer (GC) and revealed the relationship between MMPs and prognoses, clinicopathological features, tumor microenvironment, gene mutations, and drug therapy response in patients with GC. Based on the mRNA expression profiles of 45 MMP-related genes in GC, we established a model that classified GC patients into three groups based on cluster analysis of the mRNA expression profiles. The 3 groups of GC patients showed significantly different prognoses as well as tumor microenvironmental characteristics. Next, we used Boruta’s algorithm and PCA method to establish an MMP scoring system and found that lower MMP scores were associated with better prognoses, lower clinical stages, better immune cell infiltration, lower degrees of immune dysfunction and rejection, and more genetic mutations. Whereas a high MMP score was the opposite. These observations were further validated with data from other datasets, showing the robustness of our MMP scoring system. Overall, MMP could be involved in the tumor microenvironment (TME), clinical features, and prognosis of GC. An in-depth study of MMP patterns can better understand the indispensable role of MMP in the development of GC and reasonably assess the survival prognosis, clinicopathological features, and drug efficacy of different patients, thus providing clinicians with a broader vision of GC progression and treatment.https://www.frontiersin.org/articles/10.3389/fgene.2023.1128088/fullgastric cancerMMP-matrix metalloproteinaseimmunogenic profileclinical diagnosisimmunotherapyclinical treatment |
| spellingShingle | Chaofeng Yuan Jialin Yuan Huijie Xiao Haitao Li Yang Jiang Rongnan Zhai Jinjing Zhai Hua Xing Jiannan Huang Genomic analysis of matrix metalloproteinases affecting the prognosis and immunogenic profile of gastric cancer Frontiers in Genetics gastric cancer MMP-matrix metalloproteinase immunogenic profile clinical diagnosis immunotherapy clinical treatment |
| title | Genomic analysis of matrix metalloproteinases affecting the prognosis and immunogenic profile of gastric cancer |
| title_full | Genomic analysis of matrix metalloproteinases affecting the prognosis and immunogenic profile of gastric cancer |
| title_fullStr | Genomic analysis of matrix metalloproteinases affecting the prognosis and immunogenic profile of gastric cancer |
| title_full_unstemmed | Genomic analysis of matrix metalloproteinases affecting the prognosis and immunogenic profile of gastric cancer |
| title_short | Genomic analysis of matrix metalloproteinases affecting the prognosis and immunogenic profile of gastric cancer |
| title_sort | genomic analysis of matrix metalloproteinases affecting the prognosis and immunogenic profile of gastric cancer |
| topic | gastric cancer MMP-matrix metalloproteinase immunogenic profile clinical diagnosis immunotherapy clinical treatment |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2023.1128088/full |
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