Development of Processes for Recombinant L-Asparaginase II Production by <i>Escherichia coli</i> Bl21 (De3): From Shaker to Bioreactors

Development of Processes for Recombinant L-Asparaginase II Production by <i>Escherichia coli</i> Bl21 (De3): From Shaker to Bioreactors

Since 1961, L-asparaginase has been used to treat patients with acute lymphocytic leukemia. It rapidly depletes the plasma asparagine and deprives the blood cells of this circulating amino acid, essential for the metabolic cycles of cells. In the search for viable alternatives to produce L-asparagin...

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Bibliographic Details
Main Authors: Thaís Barros, Larissa Brumano, Marcela Freitas, Adalberto Pessoa, Nádia Parachin, Pérola O. Magalhães
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Pharmaceutics
Subjects:
L-asparaginase
<i>Escherichia coli</i>
IPTG
lactose
shaker
bioreactor
Online Access:https://www.mdpi.com/1999-4923/13/1/14

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