The Pseudomonas aeruginosa antimetabolite L-2-amino-4-methoxy-trans-3-butenoic acid (AMB) is made from glutamate and two alanine residues via a thiotemplate-linked tripeptide precursor

The Pseudomonas aeruginosa antimetabolite L-2-amino-4-methoxy-trans-3-butenoic acid (AMB) is made from glutamate and two alanine residues via a thiotemplate-linked tripeptide precursor

The Pseudomonas aeruginosa toxin L-2-amino-4-methoxy-trans-3-butenoic acid (AMB) is a non-proteinogenic amino acid which is toxic for prokaryotes and eukaryotes. Production of AMB requires a five-gene cluster encoding a putative LysE-type transporter (AmbA), two nonribosomal peptide synthetases (Amb...

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Bibliographic Details
Main Authors: Nelson eRojas Murcia, Xiaoyun eLee, Patrice eWaridel, Alessandro eMaspoli, Heidi J Imker, Tiancong eChai, Christopher T Walsh, Cornelia eReimmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Microbiology
Subjects:
Pseudomonas
Secondary metabolite
toxin
Thiotemplate
oxyvinylglycine
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00170/full

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