Detachment and recovery index: A new parameter measuring powder compressibility
This investigation introduces a simple and reliable approach to measure the compressibility of some direct compression excipients in tablet systems made from compressible components. The claim made here is that: the total reduction, ΔL T , in the thickness of a tablet batch due to compression at a c...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2010-01-01
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| Series: | Journal of Advanced Pharmaceutical Technology & Research |
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| Online Access: | http://www.japtr.org/article.asp?issn=2231-4040;year=2010;volume=1;issue=4;spage=406;epage=414;aulast=Aly |
| _version_ | 1811274870907994112 |
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| author | SAS Aly |
| author_facet | SAS Aly |
| author_sort | SAS Aly |
| collection | DOAJ |
| description | This investigation introduces a simple and reliable approach to measure the compressibility of some direct compression excipients in tablet systems made from compressible components. The claim made here is that: the total reduction, ΔL T , in the thickness of a tablet batch due to compression at a confined machine settings is the integral sum of small reductions generated by the compressible components in the batch. The reduction value, ΔL E , generated by a single or a blend of excipients in a batch could be calculated and was found to correlate to its concentration, C, by the relation: ΔL E =A E.C x. The constants AE and x concern the reduction tendency, RT, of the excipient particles due to compression, and detachment and recovery index (DRI), respectively. Some physicomechanical parameters characterizing the compression behavior of an excipient in a tablet batch could be determined and were found to be functions of the determine DRI of the excipient in the batch. |
| first_indexed | 2024-04-12T23:28:01Z |
| format | Article |
| id | doaj.art-3bcbe5a974ad4ada931b0c8085c4671d |
| institution | Directory Open Access Journal |
| issn | 2231-4040 0976-2094 |
| language | English |
| last_indexed | 2024-04-12T23:28:01Z |
| publishDate | 2010-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Advanced Pharmaceutical Technology & Research |
| spelling | doaj.art-3bcbe5a974ad4ada931b0c8085c4671d2022-12-22T03:12:22ZengWolters Kluwer Medknow PublicationsJournal of Advanced Pharmaceutical Technology & Research2231-40400976-20942010-01-011440641410.4103/0110-5558.76440Detachment and recovery index: A new parameter measuring powder compressibilitySAS AlyThis investigation introduces a simple and reliable approach to measure the compressibility of some direct compression excipients in tablet systems made from compressible components. The claim made here is that: the total reduction, ΔL T , in the thickness of a tablet batch due to compression at a confined machine settings is the integral sum of small reductions generated by the compressible components in the batch. The reduction value, ΔL E , generated by a single or a blend of excipients in a batch could be calculated and was found to correlate to its concentration, C, by the relation: ΔL E =A E.C x. The constants AE and x concern the reduction tendency, RT, of the excipient particles due to compression, and detachment and recovery index (DRI), respectively. Some physicomechanical parameters characterizing the compression behavior of an excipient in a tablet batch could be determined and were found to be functions of the determine DRI of the excipient in the batch.http://www.japtr.org/article.asp?issn=2231-4040;year=2010;volume=1;issue=4;spage=406;epage=414;aulast=AlyCompressionDensityDRI |
| spellingShingle | SAS Aly Detachment and recovery index: A new parameter measuring powder compressibility Journal of Advanced Pharmaceutical Technology & Research Compression Density DRI |
| title | Detachment and recovery index: A new parameter measuring powder compressibility |
| title_full | Detachment and recovery index: A new parameter measuring powder compressibility |
| title_fullStr | Detachment and recovery index: A new parameter measuring powder compressibility |
| title_full_unstemmed | Detachment and recovery index: A new parameter measuring powder compressibility |
| title_short | Detachment and recovery index: A new parameter measuring powder compressibility |
| title_sort | detachment and recovery index a new parameter measuring powder compressibility |
| topic | Compression Density DRI |
| url | http://www.japtr.org/article.asp?issn=2231-4040;year=2010;volume=1;issue=4;spage=406;epage=414;aulast=Aly |
| work_keys_str_mv | AT sasaly detachmentandrecoveryindexanewparametermeasuringpowdercompressibility |