Synthesis and reducing power assay of methyl semicarbazone derivatives
In the present study we have designed a new pharmacophore ‘Chalconesemicarbazone’ by pharmacophore hybridization approach of drug design. A series of novel chalconesemicarbazones was synthesized and evaluated for their antioxidant activity by reducing power assay. Most of the compounds were found to...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-04-01
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| Series: | Journal of Saudi Chemical Society |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610311001232 |
| _version_ | 1831631348195917824 |
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| author | Manmohan Singhal Arindam Paul Hemendra P. Singh |
| author_facet | Manmohan Singhal Arindam Paul Hemendra P. Singh |
| author_sort | Manmohan Singhal |
| collection | DOAJ |
| description | In the present study we have designed a new pharmacophore ‘Chalconesemicarbazone’ by pharmacophore hybridization approach of drug design. A series of novel chalconesemicarbazones was synthesized and evaluated for their antioxidant activity by reducing power assay. Most of the compounds were found to be potent antioxidants. Free radicals play an important role in various pathological and xenotoxic effects so antioxidant may have protective role in these pathological conditions. Based on the results of reducing power assay 1-[1-(2,4-dihydroxyphenyl)-3-(2-hydroxyphenyl)allylidene]-4-(4-methylphenyl)semicarbazide (compound 18) and 1-[1-(2,5-dihydroxyphenyl)-3-(6-hydroxyphenyl)allylidene]-4-(4-methylphenyl)semicarbazide (compound 21) were the most active lead compounds. It was found that methoxy and hydroxyl substituted chalconesemicarbazones exhibited potent reducing power and unsubstituted compound showed less reducing potential. |
| first_indexed | 2024-12-19T04:59:13Z |
| format | Article |
| id | doaj.art-3bced00e302945f48b04d39ec46f61e8 |
| institution | Directory Open Access Journal |
| issn | 1319-6103 |
| language | English |
| last_indexed | 2024-12-19T04:59:13Z |
| publishDate | 2014-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj.art-3bced00e302945f48b04d39ec46f61e82022-12-21T20:35:08ZengElsevierJournal of Saudi Chemical Society1319-61032014-04-0118212112710.1016/j.jscs.2011.06.004Synthesis and reducing power assay of methyl semicarbazone derivativesManmohan Singhal0Arindam Paul1Hemendra P. Singh2School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, IndiaG.D. Memorial College of Pharmacy, Jodhpur, Rajasthan, IndiaB.N. College of Pharmacy, Udaipur, Rajasthan, IndiaIn the present study we have designed a new pharmacophore ‘Chalconesemicarbazone’ by pharmacophore hybridization approach of drug design. A series of novel chalconesemicarbazones was synthesized and evaluated for their antioxidant activity by reducing power assay. Most of the compounds were found to be potent antioxidants. Free radicals play an important role in various pathological and xenotoxic effects so antioxidant may have protective role in these pathological conditions. Based on the results of reducing power assay 1-[1-(2,4-dihydroxyphenyl)-3-(2-hydroxyphenyl)allylidene]-4-(4-methylphenyl)semicarbazide (compound 18) and 1-[1-(2,5-dihydroxyphenyl)-3-(6-hydroxyphenyl)allylidene]-4-(4-methylphenyl)semicarbazide (compound 21) were the most active lead compounds. It was found that methoxy and hydroxyl substituted chalconesemicarbazones exhibited potent reducing power and unsubstituted compound showed less reducing potential.http://www.sciencedirect.com/science/article/pii/S1319610311001232ChalconesAnti-oxidantSemicarbazonesReducing power |
| spellingShingle | Manmohan Singhal Arindam Paul Hemendra P. Singh Synthesis and reducing power assay of methyl semicarbazone derivatives Journal of Saudi Chemical Society Chalcones Anti-oxidant Semicarbazones Reducing power |
| title | Synthesis and reducing power assay of methyl semicarbazone derivatives |
| title_full | Synthesis and reducing power assay of methyl semicarbazone derivatives |
| title_fullStr | Synthesis and reducing power assay of methyl semicarbazone derivatives |
| title_full_unstemmed | Synthesis and reducing power assay of methyl semicarbazone derivatives |
| title_short | Synthesis and reducing power assay of methyl semicarbazone derivatives |
| title_sort | synthesis and reducing power assay of methyl semicarbazone derivatives |
| topic | Chalcones Anti-oxidant Semicarbazones Reducing power |
| url | http://www.sciencedirect.com/science/article/pii/S1319610311001232 |
| work_keys_str_mv | AT manmohansinghal synthesisandreducingpowerassayofmethylsemicarbazonederivatives AT arindampaul synthesisandreducingpowerassayofmethylsemicarbazonederivatives AT hemendrapsingh synthesisandreducingpowerassayofmethylsemicarbazonederivatives |