HIV Broadly Neutralizing Antibodies Expressed as IgG3 Preserve Neutralization Potency and Show Improved Fc Effector Function

HIV Broadly Neutralizing Antibodies Expressed as IgG3 Preserve Neutralization Potency and Show Improved Fc Effector Function

The ability of several broadly neutralizing antibodies (bNAbs) to protect against HIV infection is enhanced through Fc receptor binding. Antibody isotype modulates this effect, with IgG3 associated with improved HIV control and vaccine efficacy. We recently showed that an IgG3 variant of bNAb CAP256...

Full description

Bibliographic Details
Main Authors: Simone I. Richardson, Frances Ayres, Nelia P. Manamela, Brent Oosthuysen, Zanele Makhado, Bronwen E. Lambson, Lynn Morris, Penny L. Moore
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
broadly neutralizing antibodies (bnAbs)
Fc effector function
IgG3
phagocytosis
ADCC (antibody dependent cellular cytotoxicity)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.733958/full

Similar Items

Similar Items