Gut microbiota and metabolite variations in a migraine mouse model
Migraine is a prevalent clinical disorder characterized by recurrent unilateral throbbing headache episodes accompanied by symptoms such as nausea, vomiting, photophobia, and phonophobia. Despite its common occurrence, the diagnosis, pathophysiology, and treatment of migraine remain controversial. E...
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1322059/full |
| _version_ | 1827368390356893696 |
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| author | Dan Wang Dan Wang Xu Liu Xu Liu Suming Shi Suming Shi Tongli Ren Tongli Ren Wuqing Wang Wuqing Wang |
| author_facet | Dan Wang Dan Wang Xu Liu Xu Liu Suming Shi Suming Shi Tongli Ren Tongli Ren Wuqing Wang Wuqing Wang |
| author_sort | Dan Wang |
| collection | DOAJ |
| description | Migraine is a prevalent clinical disorder characterized by recurrent unilateral throbbing headache episodes accompanied by symptoms such as nausea, vomiting, photophobia, and phonophobia. Despite its common occurrence, the diagnosis, pathophysiology, and treatment of migraine remain controversial. Extensive research has implicated the gut microbiota in various central nervous system disorders, including anxiety disorders, depression, and Parkinson’s disease. Some studies have also suggested that migraine may stem from disruptions to neurohormones and metabolism. This study aimed to investigate the disparities in gut microbiota and metabolites between migraine mice model and normal mice to shed light on the underlying mechanisms and potential therapeutic approaches. Distinct differences in gut microbial composition were observed between the migraine mouse model and normal mouse, indicating a potential correlation between these variations and the pathogenesis of migraine. This study provides evidence of differences in gut microbiota composition and metabolites between a migraine mouse model and normal mice, which showed that Akkermansiaceae constituted the most abundant taxon in the sham injection mouse group, while Lachnospiraceae constituted the most prevalent group in the migraine mouse model group. The associations between the abundances of Akkermansia muciniphila and Lachnospiraceae bacteria and metabolites suggested their potential roles in the pathogenesis of migraine. The altered abundance of Lachnospiraceae observed in migraine-afflicted mice and its correlations with changes in metabolites suggest that it may affect the host’s health. Thus, probiotic therapy emerges as a possible treatment for migraine. Moreover, significant disparities in gut metabolites were observed between the migraine mouse model and normal mice. These alterations encompass multiple metabolic pathways, suggesting that metabolic disturbances may also contribute to the development of migraines. |
| first_indexed | 2024-03-08T09:29:45Z |
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| id | doaj.art-3bd53c73bdaf47f7ae69965accc9b26f |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-08T09:29:45Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-3bd53c73bdaf47f7ae69965accc9b26f2024-01-31T04:41:19ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882024-01-011310.3389/fcimb.2023.13220591322059Gut microbiota and metabolite variations in a migraine mouse modelDan Wang0Dan Wang1Xu Liu2Xu Liu3Suming Shi4Suming Shi5Tongli Ren6Tongli Ren7Wuqing Wang8Wuqing Wang9Ear, Nose, and Throat (ENT) Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, ChinaNational Health Council (NHC) Key Laboratory of Hearing Medicine, Fudan University, Shanghai, sChinaEar, Nose, and Throat (ENT) Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, ChinaNational Health Council (NHC) Key Laboratory of Hearing Medicine, Fudan University, Shanghai, sChinaEar, Nose, and Throat (ENT) Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, ChinaNational Health Council (NHC) Key Laboratory of Hearing Medicine, Fudan University, Shanghai, sChinaEar, Nose, and Throat (ENT) Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, ChinaNational Health Council (NHC) Key Laboratory of Hearing Medicine, Fudan University, Shanghai, sChinaEar, Nose, and Throat (ENT) Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, ChinaNational Health Council (NHC) Key Laboratory of Hearing Medicine, Fudan University, Shanghai, sChinaMigraine is a prevalent clinical disorder characterized by recurrent unilateral throbbing headache episodes accompanied by symptoms such as nausea, vomiting, photophobia, and phonophobia. Despite its common occurrence, the diagnosis, pathophysiology, and treatment of migraine remain controversial. Extensive research has implicated the gut microbiota in various central nervous system disorders, including anxiety disorders, depression, and Parkinson’s disease. Some studies have also suggested that migraine may stem from disruptions to neurohormones and metabolism. This study aimed to investigate the disparities in gut microbiota and metabolites between migraine mice model and normal mice to shed light on the underlying mechanisms and potential therapeutic approaches. Distinct differences in gut microbial composition were observed between the migraine mouse model and normal mouse, indicating a potential correlation between these variations and the pathogenesis of migraine. This study provides evidence of differences in gut microbiota composition and metabolites between a migraine mouse model and normal mice, which showed that Akkermansiaceae constituted the most abundant taxon in the sham injection mouse group, while Lachnospiraceae constituted the most prevalent group in the migraine mouse model group. The associations between the abundances of Akkermansia muciniphila and Lachnospiraceae bacteria and metabolites suggested their potential roles in the pathogenesis of migraine. The altered abundance of Lachnospiraceae observed in migraine-afflicted mice and its correlations with changes in metabolites suggest that it may affect the host’s health. Thus, probiotic therapy emerges as a possible treatment for migraine. Moreover, significant disparities in gut metabolites were observed between the migraine mouse model and normal mice. These alterations encompass multiple metabolic pathways, suggesting that metabolic disturbances may also contribute to the development of migraines.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1322059/fullmigrainegut microbiomegut metabolome16S rRNA gene sequencingmicrobiota-gut-brain axis |
| spellingShingle | Dan Wang Dan Wang Xu Liu Xu Liu Suming Shi Suming Shi Tongli Ren Tongli Ren Wuqing Wang Wuqing Wang Gut microbiota and metabolite variations in a migraine mouse model Frontiers in Cellular and Infection Microbiology migraine gut microbiome gut metabolome 16S rRNA gene sequencing microbiota-gut-brain axis |
| title | Gut microbiota and metabolite variations in a migraine mouse model |
| title_full | Gut microbiota and metabolite variations in a migraine mouse model |
| title_fullStr | Gut microbiota and metabolite variations in a migraine mouse model |
| title_full_unstemmed | Gut microbiota and metabolite variations in a migraine mouse model |
| title_short | Gut microbiota and metabolite variations in a migraine mouse model |
| title_sort | gut microbiota and metabolite variations in a migraine mouse model |
| topic | migraine gut microbiome gut metabolome 16S rRNA gene sequencing microbiota-gut-brain axis |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1322059/full |
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