The Central Contributions of Breast Cancer Stem Cells in Developing Resistance to Endocrine Therapy in Estrogen Receptor (ER)-Positive Breast Cancer

The Central Contributions of Breast Cancer Stem Cells in Developing Resistance to Endocrine Therapy in Estrogen Receptor (ER)-Positive Breast Cancer

Breast cancer stem cells (BCSC) play critical roles in the acquisition of resistance to endocrine therapy in estrogen receptor (ER)-positive (ER + ve) breast cancer (BC). The resistance results from complex alterations involving ER, growth factor receptors, NOTCH, Wnt/β-catenin, hedgehog, Y...

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Bibliographic Details
Main Authors: David Rodriguez, Marc Ramkairsingh, Xiaozeng Lin, Anil Kapoor, Pierre Major, Damu Tang
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cancers
Subjects:
ER-positive breast cancer
endocrine therapy resistance
breast cancer stem cells
hormone and growth factor signaling
microenvironment
Online Access:https://www.mdpi.com/2072-6694/11/7/1028

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