Chemical Compounds, Antitumor and Antimicrobial Activities of Dry Ethanol Extracts from <i>Koelreuteria paniculata</i> Laxm
<i>Koelreuteria paniculata</i> Laxm. is used in traditional medicine and has various established biological activities, however, the species is considered to be a potentially invasive alien tree species for Bulgarian flora. However, there is still much to be studied about the phytochemic...
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MDPI AG
2021-12-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/10/12/2715 |
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| author | Tsvetelina Andonova Yordan Muhovski Hafize Fidan Iliya Slavov Albena Stoyanova Ivanka Dimitrova-Dyulgerova |
| author_facet | Tsvetelina Andonova Yordan Muhovski Hafize Fidan Iliya Slavov Albena Stoyanova Ivanka Dimitrova-Dyulgerova |
| author_sort | Tsvetelina Andonova |
| collection | DOAJ |
| description | <i>Koelreuteria paniculata</i> Laxm. is used in traditional medicine and has various established biological activities, however, the species is considered to be a potentially invasive alien tree species for Bulgarian flora. However, there is still much to be studied about the phytochemical and biological characteristics of the species. The present study aimed to determine the chemical composition of the ethanol extracts of aerial plant parts, by GC-MS analysis, and to thereby evaluate their in vitro antitumor and antibacterial properties. All three extracts were tested against the HT-29 and PC3 tumor cell lines using the MTT assay. Fifty-six components were identified from leaf, flower, and stem bark extracts, and over 10% were the following constituents: pyrogallol, <i>α</i>-terpinyl acetate, neryl acetate, and <i>α</i>-terpinyl isobutanoate. The oxygenated monoterpenes predominated in the extracts, followed by the oxygenated aliphatics and phenylpropanoids. Significant antiproliferative activity on the HT-29 cell line (IC<sub>50</sub>–21.44 µg/mL and 23.63 µg/mL, respectively) was found for the flower and leaf extracts. Antibacterial activity was established for the following bacteria strains: <i>Bacillus subtilis</i> ATCC 6633, <i>Bacillus cereus</i> NCTC 10320, <i>Escherichia coli</i> ATCC 8739, <i>Pseudomonas aeruginosa</i> ATCC 6027, and <i>Proteus vulgaris</i> ATCC 6380. The stem bark and flower extracts showed better antimicrobial potential. <i>K. paniculata</i> could be considered as a potential source of biologically active substances with antitumor and antibacterial properties. |
| first_indexed | 2024-03-10T03:16:22Z |
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| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-10T03:16:22Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-3bd9ad4478cd4e27aa0eb43d9bcf8f502023-11-23T10:12:07ZengMDPI AGPlants2223-77472021-12-011012271510.3390/plants10122715Chemical Compounds, Antitumor and Antimicrobial Activities of Dry Ethanol Extracts from <i>Koelreuteria paniculata</i> LaxmTsvetelina Andonova0Yordan Muhovski1Hafize Fidan2Iliya Slavov3Albena Stoyanova4Ivanka Dimitrova-Dyulgerova5Department of Botany and Methods of Biology Teaching, Faculty of Biology, University of Plovdiv, Paisii Hilendarski, 4000 Plovdiv, BulgariaLife Sciences Department, Walloon Agricultural Research Centre, 5030 Gembloux, BelgiumDepartment of Tourism and Culinary Management, Faculty of Economics, University of Food Technologies, 4000 Plovdiv, BulgariaDepartment of Biology, Faculty of Pharmacy, Medical University of Varna, 9000 Varna, BulgariaDepartment of Tobacco, Sugar, Vegetable and Essential Oils, Faculty of Technology, University of Food Technologies, 4000 Plovdiv, BulgariaDepartment of Botany and Methods of Biology Teaching, Faculty of Biology, University of Plovdiv, Paisii Hilendarski, 4000 Plovdiv, Bulgaria<i>Koelreuteria paniculata</i> Laxm. is used in traditional medicine and has various established biological activities, however, the species is considered to be a potentially invasive alien tree species for Bulgarian flora. However, there is still much to be studied about the phytochemical and biological characteristics of the species. The present study aimed to determine the chemical composition of the ethanol extracts of aerial plant parts, by GC-MS analysis, and to thereby evaluate their in vitro antitumor and antibacterial properties. All three extracts were tested against the HT-29 and PC3 tumor cell lines using the MTT assay. Fifty-six components were identified from leaf, flower, and stem bark extracts, and over 10% were the following constituents: pyrogallol, <i>α</i>-terpinyl acetate, neryl acetate, and <i>α</i>-terpinyl isobutanoate. The oxygenated monoterpenes predominated in the extracts, followed by the oxygenated aliphatics and phenylpropanoids. Significant antiproliferative activity on the HT-29 cell line (IC<sub>50</sub>–21.44 µg/mL and 23.63 µg/mL, respectively) was found for the flower and leaf extracts. Antibacterial activity was established for the following bacteria strains: <i>Bacillus subtilis</i> ATCC 6633, <i>Bacillus cereus</i> NCTC 10320, <i>Escherichia coli</i> ATCC 8739, <i>Pseudomonas aeruginosa</i> ATCC 6027, and <i>Proteus vulgaris</i> ATCC 6380. The stem bark and flower extracts showed better antimicrobial potential. <i>K. paniculata</i> could be considered as a potential source of biologically active substances with antitumor and antibacterial properties.https://www.mdpi.com/2223-7747/10/12/2715<i>Koelreuteria paniculata</i>dry ethanol extractsGC-MS analysischemical compoundsantitumor and antimicrobial activities |
| spellingShingle | Tsvetelina Andonova Yordan Muhovski Hafize Fidan Iliya Slavov Albena Stoyanova Ivanka Dimitrova-Dyulgerova Chemical Compounds, Antitumor and Antimicrobial Activities of Dry Ethanol Extracts from <i>Koelreuteria paniculata</i> Laxm Plants <i>Koelreuteria paniculata</i> dry ethanol extracts GC-MS analysis chemical compounds antitumor and antimicrobial activities |
| title | Chemical Compounds, Antitumor and Antimicrobial Activities of Dry Ethanol Extracts from <i>Koelreuteria paniculata</i> Laxm |
| title_full | Chemical Compounds, Antitumor and Antimicrobial Activities of Dry Ethanol Extracts from <i>Koelreuteria paniculata</i> Laxm |
| title_fullStr | Chemical Compounds, Antitumor and Antimicrobial Activities of Dry Ethanol Extracts from <i>Koelreuteria paniculata</i> Laxm |
| title_full_unstemmed | Chemical Compounds, Antitumor and Antimicrobial Activities of Dry Ethanol Extracts from <i>Koelreuteria paniculata</i> Laxm |
| title_short | Chemical Compounds, Antitumor and Antimicrobial Activities of Dry Ethanol Extracts from <i>Koelreuteria paniculata</i> Laxm |
| title_sort | chemical compounds antitumor and antimicrobial activities of dry ethanol extracts from i koelreuteria paniculata i laxm |
| topic | <i>Koelreuteria paniculata</i> dry ethanol extracts GC-MS analysis chemical compounds antitumor and antimicrobial activities |
| url | https://www.mdpi.com/2223-7747/10/12/2715 |
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