Stem cell therapy as a promising strategy in necrotizing enterocolitis
Abstract Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease that affects newborns, particularly preterm infants, and is associated with high morbidity and mortality. No effective therapeutic strategies to decrease the incidence and severity of NEC have been developed to date....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | Molecular Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s10020-022-00536-y |
| _version_ | 1818064558811512832 |
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| author | Si-Jia Di Si-Yuan Wu Tian-Jing Liu Yong-Yan Shi |
| author_facet | Si-Jia Di Si-Yuan Wu Tian-Jing Liu Yong-Yan Shi |
| author_sort | Si-Jia Di |
| collection | DOAJ |
| description | Abstract Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease that affects newborns, particularly preterm infants, and is associated with high morbidity and mortality. No effective therapeutic strategies to decrease the incidence and severity of NEC have been developed to date. Stem cell therapy has been explored and even applied in various diseases, including gastrointestinal disorders. Animal studies on stem cell therapy have made great progress, and the anti-inflammatory, anti-apoptotic, and intestinal barrier enhancing effects of stem cells may be protective against NEC clinically. In this review, we discuss the therapeutic mechanisms through which stem cells may function in the treatment of NEC. |
| first_indexed | 2024-12-10T14:37:55Z |
| format | Article |
| id | doaj.art-3bdb5fe280144ee1a0fafb92ef81389a |
| institution | Directory Open Access Journal |
| issn | 1076-1551 1528-3658 |
| language | English |
| last_indexed | 2024-12-10T14:37:55Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Medicine |
| spelling | doaj.art-3bdb5fe280144ee1a0fafb92ef81389a2022-12-22T01:44:47ZengBMCMolecular Medicine1076-15511528-36582022-09-0128111210.1186/s10020-022-00536-yStem cell therapy as a promising strategy in necrotizing enterocolitisSi-Jia Di0Si-Yuan Wu1Tian-Jing Liu2Yong-Yan Shi3Department of Pediatrics, Shengjing Hospital of China Medical UniversityDepartment of Pediatrics, Shengjing Hospital of China Medical UniversityDepartment of Pediatrics, Shengjing Hospital of China Medical UniversityDepartment of Pediatrics, Shengjing Hospital of China Medical UniversityAbstract Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease that affects newborns, particularly preterm infants, and is associated with high morbidity and mortality. No effective therapeutic strategies to decrease the incidence and severity of NEC have been developed to date. Stem cell therapy has been explored and even applied in various diseases, including gastrointestinal disorders. Animal studies on stem cell therapy have made great progress, and the anti-inflammatory, anti-apoptotic, and intestinal barrier enhancing effects of stem cells may be protective against NEC clinically. In this review, we discuss the therapeutic mechanisms through which stem cells may function in the treatment of NEC.https://doi.org/10.1186/s10020-022-00536-yNecrotizing enterocolitisStem cellsInfants |
| spellingShingle | Si-Jia Di Si-Yuan Wu Tian-Jing Liu Yong-Yan Shi Stem cell therapy as a promising strategy in necrotizing enterocolitis Molecular Medicine Necrotizing enterocolitis Stem cells Infants |
| title | Stem cell therapy as a promising strategy in necrotizing enterocolitis |
| title_full | Stem cell therapy as a promising strategy in necrotizing enterocolitis |
| title_fullStr | Stem cell therapy as a promising strategy in necrotizing enterocolitis |
| title_full_unstemmed | Stem cell therapy as a promising strategy in necrotizing enterocolitis |
| title_short | Stem cell therapy as a promising strategy in necrotizing enterocolitis |
| title_sort | stem cell therapy as a promising strategy in necrotizing enterocolitis |
| topic | Necrotizing enterocolitis Stem cells Infants |
| url | https://doi.org/10.1186/s10020-022-00536-y |
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